5篇
您的检索式：作者名="David Leonhardt"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination显示文摘 | Weihua Qin Patricia Wolf Nan Liu Stephanie Link Martha Smets Federica La Mastra Ignasi Forne Garwin Pichler David Horl Karin Fellinger Fabio Spada Ian Marc Bonapace Axel Imhof Hartmann Harz Heinrich Leonhardt | 2015 | Cell Research2015，25，8： | 5 |
| 2 | Overexpres-sion of AtHMA4 enhances root-to-shoot translocation of zinc and cadmium and plant metal tolerance显示文摘 | Verret F Gravot A Auroy P Leonhardt N David P Nus-saume L Vavasseur A and Richaud P | | 0，，03： | 1 |
| 3 | Overexpression of AtHMA4 enhances root-to-shoot translocation of zinc and cadmium and plant metal tolerance显示文摘 | Frédéric Verret Antoine Gravot Pascaline Auroy Nathalie Leonhardt Pascale David Laurent Nussaume Alain Vavasseur Pierre Richaud | 2004 | FEBS Letters2004，，3： | 1 |
| 4 | Analysis of the effect of bore centerline on projectile exit conditions in small arms显示文摘Most finite element models of small arms focus on an idealized barrel,typically one with a perfectly straight bore centerline.Using five different experimentally measured bore centerlines,this investigation analyzes the effect centerline nonlinearity has on projectile exit conditions.This includes the effect of rotating a centerline through several orientations.Modeled using Abaqus/Explicit,this dynamic analysis simulates a single firing cycle for each centerline.Projectile jump is calculated for each model as a measure of the effects of warped centerlines.The warped centerlines have a small effect on barrel dynamics. | David Leonhardt Mark Garnich Miljenko Lucic | 2022 | Defence Technology(防务技术)2022，18，12： | 1 |
| 5 | Artificial intelligence for closed-loop ventilation therapy with hemodynamic control using the open lung concept显示文摘Purpose–The purpose of this paper is to develop an automatic control system for mechanical ventilation therapy based on the open lung concept(OLC)using artificial intelligence.In addition,mean arterial blood pressure(MAP)is stabilized by means of a decoupling controller with automated noradrenaline(NA)dosage to ensure adequate systemic perfusion during ventilation therapy for patients with acute respiratory distress syndrome(ARDS).Design/methodology/approach–The aim is to develop an automatic control system for mechanical ventilation therapy based on the OLC using artificial intelligence.In addition,MAP is stabilized by means of a decoupling controller with automated NA dosage to ensure adequate systemic perfusion during ventilation therapy for patients with ARDS.Findings–Thisinnovativeclosed-loop mechanicalventilation system leadsto a significant improvement in oxygenation,regulates end-tidal carbon dioxide for appropriate gas exchange and stabilizes MAP to guarantee proper systemic perfusion during the ventilation therapy.Research limitations/implications–Currently,this automatic ventilation system based on the OLC can only be applied in animal trials;for clinical use,such a system generally requires a mechanical ventilator and sensors with medical approval for humans.Practical implications–For implementation of a closed-loop ventilation system,reliable signals from the sensors are a prerequisite for successful application.Originality/value–Theexperiment with porcine dynamics demonstrates thefeasibility and usefulness of this automatic closed-loop ventilation therapy,with hemodynamic control for severe ARDS.Moreover,this pilot study validated a new algorithm for implementation of the OLC,whereby all control objectives are fulfilled during the ventilation therapy with adequate hemodynamic control of patients with ARDS. | Anake Pomprapa Danita Muanghong Marcus Köny Steffen Leonhardt Philipp Pickerodt Onno Tjarks David Schwaiberger Burkhard Lachmann | 2015 | International Journal of Intelligent Computing and Cybernetics2015，8，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员