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| 1 | Metastatic type 1 gastric carcinoid:A real threat or just a myth?显示文摘AIM:To describe disease characteristics and treatment modalities in a group of rare patients with metastatic gastric carcinoid type 1(GCA1).METHODS:Information on clinical,biochemical,radiological,histopathological findings,the extent of the disease,as well as the use of different therapeutic modalities and the long-term outcome were recorded.Patients’data were assessed at presentation,and thereafter at 6 to 12 monthly intervals both clinically and biochemically,but also endoscopically and histopathologically.Patients were evaluated for the presence of specific symptoms;the presence of autoimmune disorders and the presence of other gastrointestinal malignancies in other family members were also recorded.The evaluation of response to treatment was defined using established WHO criteria.RESULTS:We studied twenty consecutive patients with a mean age of 55.1 years.The mean follow-up period was 83 mo.Twelve patients had regional lymph node metastases and 8 patients had liver metastases.The primary tumor mean diameter was 20.13±10.83mm(mean±SD).The mean Ki-67 index was 6.8%±11.2%.All but one patient underwent endoscopic or surgical excision of the tumor.The disease was stable in all but 3 patients who had progressive liver disease.All patients remained alive during the follow-up period.CONCLUSION:Metastatic GCA1 carries a good overall prognosis,being related to a tumor size of≥1 cm,an elevated Ki-67 index and high serum gastrin levels. | Simona Grozinsky-Glasberg Dimitrios Thomas Jonathan R Strosberg Ulrich-Frank Pape Stephan Felder Apostolos V Tsolakis Krystallenia I Alexandraki Merav Fraenkel Leonard Saiegh Petachia Reissman Gregory Kaltsas David J Gross | 2013 | World Journal of Gastroenterology2013，19，46： | 11 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 4 | Diagnosis, management, and treatment of hepatitis C: An update显示文摘 | Marc G. Ghany Doris B. Strader David L. Thomas Leonard B. Seeff | 2009 | Hepatology2009，，4： | 3 |
| 5 | Ulcerative colitis neoplasia is not associated with common IBD SNPs显示文摘 | Tara M. Connelly Arthur S. Berg Leonard R. Harris David L. Brinton John P. Hegarty Susan M. Deiling David B. Stewart Walter A. Koltun | 2014 | Surgery2014，，： | 2 |
| 6 | Hepatocellular carcinoma screening in patients waiting for liver transplantation: A decision analytic model显示文摘 | Sammy Saab David Ly Jose Nieto Fasiha Kanwal David Lu Steven Raman Rafael Amado Barbara Nuesse Francisco Durazo Steven Han Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Pauline Chen Kathy Schwegel Leonard I. Goldstein Myron Tong Ronald W. Busuttil | 2003 | Liver Transplantation2003，，7： | 2 |
| 7 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 8 | A systematic review on the safety and efficacy of yttrium-90 radioembolization for unresectable, chemorefractory colorectal cancer liver metastases显示文摘 | Akshat Saxena Lourens Bester Leonard Shan Marlon Perera Peter Gibbs Baerbel Meteling David L. Morris | 2014 | Journal of Cancer Research and Clinical Oncology2014，，4： | 2 |
| 9 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 10 | SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle显示文摘 | Takashi Nakagawa David J. Lomb Marcia C. Haigis Leonard Guarente | 2009 | Cell2009，，3： | 2 |
| 11 | A Method for Quantifying Vulnerability, Applied to the Agricultural System of the YaquiValley, Mexico 显示文摘 | Amy LL David B L Leonard S S | 2003 | Global Environmental Change2003，13，： | 1 |
| 12 | Identification of a volatile component in soybeans that contributes to raw bean flavor显示文摘 | LEONARD R MATTICK DAVID B HAND | 1969 | Journal of Agricukural Food Chemistry1969，17，1： | 1 |
| 13 | Heterogeneity and oxidation status of commercial human albumin preparations in clinical use显示文摘 | David Bar-Or Raphael Bar-Or Leonard T. Rael David K. Gardner Denetta S. Slone Michael L. Craun | 2005 | Critical Care Medicine2005，，7： | 1 |
| 14 | Geographic Information System, Decision Support System, and Urban Storm-Water Management 显示文摘 | David J Sample James P Heaney Leonard T Wright | 2001 | Journal of Water Resources Planning and Management2001，127，3： | 1 |
| 15 | L-Homoarginine and L-arginine are antagonistically related to blood pressure in an elderly population: the Hoorn study显示文摘 | Leonard P. van der Zwan Mariska Davids Peter G. Scheffer Jacqueline M. Dekker Coen D.A. Stehouwer Tom Teerlink | 2013 | Journal of Hypertension2013，，6： | 1 |
| 16 | Hepatic neuroendocrine metastases: does intervention alter outcomes? 1 1 No competing interests declared.显示文摘 | Ronald S Chamberlain David Canes Karen T Brown Leonard Saltz William Jarnagin Yuman Fong Leslie H Blumgart | 2000 | Journal of the American College of Surgeons2000，，4： | 1 |
| 17 | Notes on the biology of the sea nettle,Chrysaora quinquecirrha, in Chesapeake Bay显示文摘 | David G. Cargo Leonard P. Schultz | 1966 | Chesapeake Science1966，，2： | 1 |
| 18 | HYPERLIPIDEMIA AFTER LIVER TRANSPLANTATION: Natural History and Treatment with the Hydroxy-Methylglutaryl-Coenzyme A Reductase Inhibitor Pravastatin1显示文摘 | David K. Imagawa Sherfield Dawson Curtis D. Holt Pamela S. Kirk Fady M. Kaldas Christopher R. Shackleton Philip Seu Steve M. Rudich Milan M. Kinkhabwala Paul Martin Leonard I. Goldstein Natalie G.B. Murray Paul I. Terasaki Ronald W. Busuttil | 1996 | Transplantation1996，，7： | 1 |
| 19 | Clinical Utility of the Cobalt-Albumin Binding Assay in the Diagnosis of Intestinal Ischemia显示文摘 | Jonathan D. Polk Leonard T. Rael Michael L. Craun Charles W. Mains Deborah Davis-Merritt David Bar-Or | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，： | 1 |
| 20 | SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells显示文摘 | Marcia C. Haigis Raul Mostoslavsky Kevin M. Haigis Kamau Fahie Danos C. Christodoulou Andrew J. Murphy David M. Valenzuela George D. Yancopoulos Margaret Karow Gil Blander Cynthia Wolberger Tomas A. Prolla Richard Weindruch Frederick W. Alt Leonard Guaren | 2006 | Cell2006，，5： | 1 |
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