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| 1 | Diabetic nephropathy:Is it time yet for routine kidney biopsy?显示文摘Diabetic nephropathy(DN)is one of the most important long-term complications of diabetes.Patients with diabetes and chronic kidney disease have an increased risk of all-cause mortality,cardiovascular mortality,and kidney failure.The clinical diagnosis of DN depends on the detection of microalbuminuria.This usually occurs after the first five years from the onset of diabetes,and predictors of DN development and progression are being studied but are not yet implemented into clinical practice.Diagnostic tests are useful tools to recognize onset,progression and response to therapeutic interventions.Microalbuminuria is an indicator of DN,and it is considered the only noninvasive marker of early onset.However,up to now there is no diagnostic tool that can predict which patients will develop DN before any damage is present.Pathological renal injury is hard to predict only with clinical and laboratory findings.An accurate estimate of damage in DN can only be achieved by the histological analysis of tissue samples.At the present time,renal biopsy is indicated on patients with diabetes under the suspicion of the presence of nephropathies other than DN.Results from renal biopsies in patients with diabetes had made possible the classification of renal biopsies in three major groups associated with different prognostic features:diabetic nephropathy,non-diabetic renal disease(NDRD),and a superimposed non-diabetic condition on underlying diabetic nephropathy.In patients with type 2 diabetes with a higher degree of suspicion for NDRD,it is granted the need of a renal biopsy.It is important to identify and differentiate these pathologies at an early stage in order to prevent progression and potential complications.Therefore,a more extensive use of biopsy is advisable. | Maria L Gonzalez Suarez David B Thomas Laura Barisoni Alessia Fornoni | 2013 | World Journal of Diabetes2013，4，6： | 29 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Shortness of breath in clinical practice: A case for left atrial function and exercise stress testing for a comprehensive diastolic heart failure workup显示文摘The symptom cluster of shortness of breath(SOB) contributes significantly to the outpatient workload of cardiology services. The workup of these patients includes blood chemistry and biomarkers, imaging and functional testing of the heart and lungs. A diagnosis of diastolic heart failure is inferred through the exclusion of systolic abnormalities, a normal pulmonary function test and normal hemoglobin, coupled with diastolic abnormalities on echocardiography. Differentiating confounders such as obesity or deconditioning in a patient with diastolic abnormalities is difficult. While the most recent guidelines provide more avenues for diagnosis, such as incorporating the left atrial size, little emphasis is given to understanding left atrial function, which contributes to at least 25% of diastolic left ventricular filling; additionally, exercise stress testing to elicit symptoms and test the dynamics of diastolic parameters, especially when access to the 'gold standard' invasive tests is lacking, presents clinical translational gaps. It is thus important in diastolic heart failure work up to understand left atrial mechanics and the role of exercise testing to build a comprehensive argument for the diagnosis of diastolic heart failure in a patient presenting with SOB. | Pupalan Iyngkaran Nagesh S Anavekar Christopher Neil Liza Thomas David L Hare | 2017 | World Journal of Methodology2017，7，4： | 5 |
| 4 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 5 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 6 | Occult hepatitis B显示文摘 | Michael Torbenson David L Thomas | 2002 | The Lancet Infectious Diseases2002，，8： | 2 |
| 7 | Occult hepatitis B显示文摘 | Michael Torbenson David L Thomas | 2002 | Lancet Infect Dis2002，2，： | 1 |
| 8 | SCADA On Web - Web Based Supervisory Control and Data Acquisition 显示文摘 | THOMAS D DAVID L ANDREA S | 2003 | ISWC 2003 LNCS 28702003，，： | 1 |
| 9 | Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation显示文摘 | THOMAS R B DAVID L M GUO R F | 2005 | Oncogene2005，24，15： | 1 |
| 10 | Prevalence of sleep disturbances in Chinese patients with end stage renal failure on maintenance hemodialysis显示文摘 | David SCH Teresa YH Thomas L | 2002 | Med Sci Monit2002，8，5： | 1 |
| 11 | Identification of polymorphic outer membrane protein of Chlamydia psittaic 6BC 显示文摘 | Regina J T David L Thomas P H | 2001 | Infect and Immun2001，69，： | 1 |
| 12 | US Multicenter Experience With the Wingspan Stent System for the Treatment of Intracranial Atheromatous Disease: Periprocedural Results显示文摘 | David Fiorella Elad I. Levy Aquilla S. Turk Felipe C. Albuquerque David B. Niemann Beverly Aagaard-Kienitz Ricardo A. Hanel Henry Woo Peter A. Rasmussen L Nelson Hopkins Thomas J. Masaryk Cameron G. McDougall | 2007 | Stroke2007，，3： | 1 |
| 13 | Mo- lecular cloning and characterization of the human clock gene: expression in the suprachiasmatic nuclei 显示文摘 | THOMAS D L STEEVE S DAVID P K | 1999 | Genomics1999，，57： | 1 |
| 14 | Pharmacokineties of extended-re- lease epidural morphine sulfate:peoled analysis of six clinical studies 显示文摘 | Eugene R David R Thomas L | 2009 | The Veterinary Journal2009，181，3： | 1 |
| 15 | Seasonal changes in the respiratory electron transport system (ETS) and respiration of the zebra mussel,Dreissena polymorpha in Saginaw Bay?Lake Huron显示文摘 | DAVID L F THOMAS F N THOMAS H J | 2001 | Hydrobiologia2001，448，： | 1 |
| 16 | Dam Removal: challenges and opportunities for ecological research and river restoration显示文摘 | HART David D JOHNSON Thomas E BUSHAW-NEWTON Karen L | 2002 | BioScience2002，52，8： | 1 |
| 17 | Contribution of abnormal central blood pressure to left ventricular filling pressure during exercise in patients with heart failure and preserved ejection fraction显示文摘 | David J Holland Julian W Sacre Rodel L Leano Thomas H Marwick James E Sharman | 2011 | Journal of Hypertension2011，，： | 1 |
| 18 | Release behavior for powder injection molding in stereo lithography molds 显示文摘 | James G H Thomas L S David W R | 2001 | Rapid Prototyping Journai2001，7，2： | 1 |
| 19 | Essentials of strategic Management显示文摘 | Thomas L·Wheelen | 2004 | (3)2004，，3： | 1 |
| 20 | Pathophysiologic and Therapeutic Importance of Tissue ACE: A Consensus Report显示文摘 | Victor J. Dzau Kenneth Bernstein David Celermajer Jerome Cohen Bj?rn Dahl?f John Deanfield Javier Diez Helmut Drexler Roberto Ferrari Wiek van Gilst Lennart Hansson Burkhard Hornig Ahsan Husain Colin Johnston Harold Lazar Eva Lonn Thomas Lüscher John Manc | 2002 | Cardiovascular Drugs and Therapy2002，，2： | 1 |
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