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| 1 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 2 | Maintenance of Remission Among Patients With Crohn’s Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped显示文摘 | Edouard Louis Jean–Yves Mary Gwenola Vernier–Massouille Jean–Charles Grimaud Yoram Bouhnik David Laharie Jean–Louis Dupas Hélène Pillant Laurence Picon Michel Veyrac Mathurin Flamant Guillaume Savoye Raymond Jian Martine DeVos Rapha?l Porcher Gilles Paint | 2012 | Gastroenterology2012，，1： | 4 |
| 3 | Solar cell efficiency tables (Version 23)显示文摘 | Martin A Green Keith Emery David L King | 2004 | Prog Photovolt:ResAppl2004，12，： | 1 |
| 4 | Sustained release of vascular endothelial growth factor from mineralized poly (lactide-co-glycolide) scaffolds for tissue engineering显示文摘 | WILLIAM L M MARTIN C P DAVID H | 2000 | Biomaterials2000，21，： | 1 |
| 5 | Bioaugmentation for accelerated in situ anaerobic bioremediation 显示文摘 | David E E Edward J L Martin J O | 2000 | Environ SciTechnol2000，34，11： | 1 |
| 6 | Solar cell efficiency tables (Version 22)显示文摘 | MARTIN A GREEN KEITH EMERY DAVID L KING | 2003 | Progress in Photovoltaics:Research and Applications2003，，11： | 1 |
| 7 | Ex Vivo bone formation in bovine trabecular bone cultured in a dynamic 3D bioreactor is enhanced by compressive mechanical strain显示文摘 | David V Guignandon A Martin A Malaval L Lafage-Proust MH Rattner A Mann V Noble B Jones DB Vico L | | 0，，： | 1 |
| 8 | Practical application of on-line hot strip inspection system at hoogovens 显示文摘 | DAVID G P MARTIN P L HANEGHEM A V | 1995 | Iron and Steel Engineer1995，72，7： | 1 |
| 9 | Pediatric hernias显示文摘 | Joy L Graf Michael G Caty David J Martin Philip L Glick | 2002 | Seminars in Ultrasound, CT, and MRI2002，，： | 1 |
| 10 | Detailed transcription map of Aleutian mink disease pavovirus显示文摘 | Marshall E Bloom David A Martin Katfina L | 1988 | Virol1988，62，： | 1 |
| 11 | Wound healing: Biologic features and approaches to maximize healing trajectories显示文摘 | Martin C Robson David L Steed Michael G Franz | 2001 | Current Problems in Surgery2001，，： | 1 |
| 12 | Risk management in the lusoponte concessiona case study of the two bridges in Lisbon, Portugal 显示文摘 | TERESA L DAVIDE MARTIN B | 2004 | International Journal of Project Management2004，22，： | 1 |
| 13 | Aspirin dose and six-month outcome after an acute coronary syndrome显示文摘 | Martin J Quinn Herbert D Aronow Robert M Califf Deepak L Bhatt Shelly Sapp Neal S Kleiman Robert A Harrington David F Kong David E Kandzari Eric J Topol | 2004 | Journal of the American College of Cardiology2004，，6： | 1 |
| 14 | Approaching the prepa- ration of Pd-Al2O3 Catalyst systematically: one step closer to reproducible catalyst synthesis 显示文摘 | Tatjana C Martin H David L | 2006 | Stud in Surf Sci Catal2006，162，1： | 1 |
| 15 | A new classification of Cyperaceae (Poales) supported by phylogenomic data显示文摘Cyperaceae(sedges)are the third largest monocot family and are of considerable economic and ecological importance.Sedges represent an ideal model family to study evolutionary biology due to their species richness,global distribution,large discrepancies in lineage diversity,broad range of ecological preferences,and adaptations including multiple origins of C4 photosynthesis and holocentric chromosomes.Goetghebeur′s seminal work on Cyperaceae published in 1998 provided the most recent complete classification at tribal and generic level,based on a morphological study of Cyperaceae inflorescence,spikelet,flower,and embryo characters,plus anatomical and other information.Since then,several family-level molecular phylogenetic studies using Sanger sequence data have been published.Here,more than 20 years after the last comprehensive classification of the family,we present the first family-wide phylogenomic study of Cyperaceae based on targeted sequencing using the Angiosperms353 probe kit sampling 311 accessions.In addition,62 accessions available from GenBank were mined for overlapping reads and included in the phylogenomic analyses.Informed by this backbone phylogeny,a new classification for the family at the tribal,subtribal,and generic levels is proposed.The majority of previously recognized suprageneric groups are supported,and for the first time,we establish support for tribe Cryptangieae as a clade including the genus Koyamaea.We provide a taxonomic treatment including identification keys and diagnoses for the 2 subfamilies,24 tribes,and 10 subtribes,and basic information on the 95 genera.The classification includes five new subtribes in tribe Schoeneae:Anthelepidinae,Caustiinae,Gymnoschoeninae,Lepidospermatinae,and Oreobolinae. | Isabel Larridon Alexandre R.Zuntini Étienne Léveillé-Bourret Russell L.Barrett Julian R.Starr AMuthama Muasya Tamara Villaverde Kenneth Bauters Grace E.Brewer Jeremy J.Bruhl Suzana M.Costa Tammy L.Elliott Niroshini Epitawalage Marcial Escudero Isabel Fairlie Paul Goetghebeur Andrew LHipp Pedro Jiménez-Mejías Izai ABSabino Kikuchi Modesto Luceño JoséIgnacio Márquez-Corro Santiago Martín-Bravo Olivier Maurin Lisa Pokorny Eric HRoalson Ilias Semmouri David A.Simpson Daniel Spalink WWayt Thomas Karen L.Wilson Martin Xanthos Félix Forest William J.Baker | 2021 | Journal of Systematics and Evolution2021，59，4： | 1 |
| 16 | Sustained release of vascular endothelial growth factor from mineralized poly (lactide-co-glycolide) scaffolds for tissue engineeing显示文摘 | William L Murphy Martin C Peters David H Kohn | 2000 | Biomate-rials2000，21，： | 1 |
| 17 | Scintigraphic Assessment of Regionalized Defects in Myocardial Sympathetic Innervation and Blood Flow Regulation in Diabetic Patients With Autonomic Neuropathy显示文摘 | Martin J Stevens Firat Dayanikli David M Raffel Kevin C Allman Tracy Sandford Eva L Feldman Donald M Wieland James Corbett Marcus Schwaiger | 1998 | Journal of the American College of Cardiology1998，，7： | 1 |
| 18 | Solar cell efficiency tables (Version 22)显示文摘 | MARTIN A GREEN KEITH EMERY DAVID L KING | 2003 | Progress in Photovoltaics:Research and Applications2003，，11： | 1 |
| 19 | Chlorination of indicator bacteria and viruses in primary sewage effluent 显示文摘 | Julia A T Martin R A and David N L | 2003 | Appl Envi- ron Microbio12003，69，4： | 1 |
| 20 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
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