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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Hepatic expression and cellular distribution of the glucose transporter family显示文摘Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required. | Sumera Karim David H Adams Patricia F Lalor | 2012 | World Journal of Gastroenterology2012，18，46： | 5 |
| 3 | Target coverage for head and neck cancers treated with IMRT: review of clinical experiences显示文摘 | Adam S Garden William H Morrison David I Rosenthal K.S.Clifford Chao K.Kian Ang | 2004 | Seminars in Radiation Oncology2004，，： | 2 |
| 4 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 5 | 显示文摘 | YANG S H DRABOLD DAVID A ADAMS JAMES B | 1997 | J Phys:Condens Matter1997，9，： | 1 |
| 6 | Changes in human hepatic metabolism in steatosis and cirrhosis显示文摘AIM To understand the underlying metabolic changes in human liver disease we have applied nuclear magnetic resonance(NMR) metabolomics analysis to human liver tissue.METHODS We have carried out pilot study using 1H-NMR to derive metabolomic signatures from human liver from patients with steatosis, nonalcoholic steatohepatitis(NASH) or alcohol-related liver damage(ARLD) to identify species that can predict outcome and discriminate between alcohol and metabolic-induced liver injuries. RESULTS Changes in branched chain amino acid homeostasis, tricarboxylic acid cycle and purine biosynthesis intermediates along with betaine were associated with the development of cirrhosis in both ARLD and nonalcoholic fatty liver disease. Species such as propylene glycol and as yet unidentified moieties that allowed discrimination between NASH and ARLD samples were also detected using our approach.CONCLUSION Our high throughput, non-destructive technique for multiple analyte quantification in human liver specimens has potential for identification of biomarkers with prognostic and diagnostic significance. | Zoe Schofield Michelle AC Reed Philip N Newsome David H Adams Ulrich L Günther Patricia F Lalor | 2017 | World Journal of Gastroenterology2017，23，15： | 1 |
| 7 | Modelling biomeehanics of bark patterning in grasstrees显示文摘 | HOLLY D ADAM R DAVID H | 2014 | Annals of Botany2014，114，4： | 1 |
| 8 | The effects of tungsten addition on the microtexture and mechanical behavior of tantalum plate 显示文摘 | Schwartz Adam J Lassila David H LeBlanc Mary M | 1998 | Materials Science & Engineering1998，244，2： | 1 |
| 9 | Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease显示文摘 | Allister J Grant Patricia F Lalor Marko Salmi Sirpa Jalkanen David H Adams | 2002 | The Lancet2002，，9301： | 1 |
| 10 | A Fast XPS study of the surface chemistry of ethanol over Pt{1 1 1} 显示文摘 | Adam F L David E G Nicholas J H | 2004 | Surf Sci2004，548，： | 1 |
| 11 | Adapting to Dams: Agrarian change downstream of the Tiga dam Northern Nigeria显示文摘 | Thomas David H L Adams William M | 1999 | World development1999，27，6： | 1 |
| 12 | Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial显示文摘 | Guy L Clifton Alex Valadka David Zygun Christopher S Coffey Pamala Drever Sierra Fourwinds L Scott Janis Elizabeth Wilde Pauline Taylor Kathy Harshman Adam Conley Ava Puccio Harvey S Levin Stephen R McCauley Richard D Bucholz Kenneth R Smith John H Schmid | 2011 | Lancet Neurology2011，，2： | 1 |
| 13 | Mechanisms of immune-mediated liverinjury显示文摘 | David H Adams Cynthia Ju | 2010 | Toxicol Sci2010，115，2： | 1 |
| 14 | Implementation research:what it is and how to do it显示文摘 | Peters David H Adam Taghreed Alonge Olakunle | 2013 | BMJ2013，347，： | 1 |
| 15 | Empirical Orthogonal Functions: The Medium is the Message显示文摘 | Monahan Adam H Fyfe John C Ambaum Maarten H P Stephenson David B North Gerald R | 2009 | Journal of Climate2009，，24： | 1 |
| 16 | Cardiowlscular surgery in pa- tients with HIV:epidemiology, current indications and long-term outcome 显示文摘 | Javier G David H Adams B | 2008 | Rev Esp Cardiol2008，61，5： | 1 |
| 17 | Optimized two-dimensional thin layer chromatography to monitor the int racellular concentrat ion of acetylphosphate and other small phosphorylated molecules显示文摘 | David H Keating Ana Shulla Adam H Klein | 2008 | Biol Proced2008，10，1： | 1 |
| 18 | Target converage for head and neck cancers treated with IMRT: review of clinical experiences显示文摘 | Adam S G William H M David I R | 2004 | Semin Radiat Oncol2004，14，2： | 1 |
| 19 | Selective fusion of out-of-sequence measurements 显示文摘 | Dimitris K Tasoulis Niall M Adams David J H | 2010 | Information Fusion2010，11，2： | 1 |
| 20 | Cardiovascular surgery in patients with HIV: epidemiology, current indications and long-term outcome 显示文摘 | Javier G David H Adams B | 2008 | Rev Esp Cardiol2008，61，5： | 1 |
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