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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 3 | Serum Metabolic Profiling in Inflammatory Bowel Disease显示文摘 | Horace Williams James Willsmore I. Cox David Walker Jeremy Cobbold Simon Taylor-Robinson Timothy Orchard | 2012 | Digestive Diseases and Sciences2012，，8： | 2 |
| 4 | One-Year Clinical Results With the Slow-Release, Polymer-Based, Paclitaxel-Eluting TAXUS Stent: The TAXUS-IV Trial显示文摘 | Gregg W. Stone Stephen G. Ellis David A. Cox James Hermiller Charles O’Shaughnessy James Tift Mann Mark Turco Ronald Caputo Patrick Bergin Joel Greenberg Jeffrey J. Popma Mary E. Russell | 2004 | Circulation: Journal of the American Heart Association2004，，16： | 2 |
| 5 | Meshed capillary vessels found on narrow-band imaging without optical magnification effectively identifies colorectal neoplasia: a North American validation of the Japanese experience显示文摘 | Zachary H. Henry Paul Yeaton Vanessa M. Shami Michel Kahaleh James T. Patrie Dawn G. Cox David A. Peura Fabian Emura Andrew Y. Wang | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 6 | Prevention and Control of Influenza with Vaccines Recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010显示文摘 | Fiore Anthony E Uyeki Timothy M Broder Karen Finelli Lyn Euler Gary L Singleton James A Iskander John K Wortley Pascale M Shay David K Bresee Joseph S Cox Nancy J | 2010 | MMWR. Morbidity and Mortality Weekly Report2010，，： | 1 |
| 7 | Regression Models and Life Tables 显示文摘 | Cox David R | 1972 | Journal of the Royal Statistics Society1972，34，： | 1 |
| 8 | mechanisms of disease:Transforming growth factor-β显示文摘 | David A Cox Thomas Maurer | 1997 | Cli Immuno And ISmmunopathology1997，83，： | 1 |
| 9 | Soil Microbial Responses to Temporal Variations of Moisture and Temperature in a Chihuahuan Desert Grassland显示文摘 | Colin Bell Nancy McIntyre Stephen Cox David Tissue John Zak | 2008 | Microbial Ecology2008，，1： | 1 |
| 10 | A sorting classification of parallel rendering显示文摘 | Molnar Steven Cox Michael Ellsworth David | 1994 | IEEE Computer Graphics and Applications1994，14，4： | 1 |
| 11 | The mu-basis Of a rational parametric surface显示文摘 | Falai Chen David Cox Yang Liu | 2005 | Journal of Symbolic Computation2005，39，： | 1 |
| 12 | Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C显示文摘 | Andrea L. Cox Timothy Mosbruger Georg M. Lauer Drew Pardoll David L. Thomas Stuart C. Ray | 2005 | Hepatology2005，，1： | 1 |
| 13 | Bacterial respiratory tract infections are promoted by systemic hyperglycemia after severe burn injury in pediatric patients显示文摘 | Robert Kraft David N. Herndon Ronald P. Mlcak Celeste C. Finnerty Robert A. Cox Felicia N. Williams Marc G. Jeschke | 2014 | Burns2014，，3： | 1 |
| 14 | Frequency, correlates, and clinical implications of myocardial perfusion after primary angioplasty and stenting, with and without glycoprotein IIb/IIIa inhibition, in acute myocardial infarction显示文摘 | Costantino O. Costantini Gregg W. Stone Roxana Mehran Eve Aymong Cindy L. Grines David A. Cox Thomas Stuckey Mark Turco Bernard J. Gersh James E. Tcheng Eulogio Garcia John J. Griffin Giulio Guagliumi Martin B. Leon Alexandra J. Lansky | 2004 | Journal of the American College of Cardiology2004，，2： | 1 |
| 15 | Assessment and Management of Acute Coronary Syndromes (ACS): A Canadian Perspective on Current Guideline-Recommended Treatment – Part 2: ST-Segment Elevation Myocardial Infarction显示文摘 | David H. Fitchett Pierre Theroux James M. Brophy Warren J. Cantor Jafna L. Cox Milan Gupta Heather Kertland Shamir R. Mehta Robert C. Welsh Shaun G. Goodman | 2011 | Canadian Journal of Cardiology2011，，6： | 1 |
| 16 | Attributable cost of catheter-associated bloodstream infections among intensive care patients in a nonteaching hospital显示文摘 | David K. Warren Wasim W. Quadir Christopher S. Hollenbeak Alexis M. Elward Michael J. Cox Victoria J. Fraser | 2006 | Critical Care Medicine2006，，8： | 1 |
| 17 | 显示文摘 | Clair Todd P St Oyama S Ted Cox David F | 1999 | Surface Science1999，426，2： | 1 |
| 18 | A Sorting Classification of Parallel Rendering显示文摘 | Steven Molnar Michael Cox David Ellsworth Henry Fuchs | 1994 | IEEE Computer Graphics & Applications1994，14，4： | 1 |
| 19 | Separate effects of the microkeratome incision and laser ablation on the eye' s wave aberration显示文摘 | Porter J MacRae S Yoon G Roberts C Cox IG David R | 2003 | Am J Ophthalmol2003，136，2： | 1 |
| 20 | A Sorting Classification of Parallel Rendering 显示文摘 | Steven Molnar Michael Cox David Ellsworth Henry Fuchs | 1994 | IEEE Computer Graph and Application (S0272-1716)1994，14，4： | 1 |
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