|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
| 2 | Identification of ssDNA aptamers specific to clinical isolates of Streptococcus mutans strains with different cariogenicity显示文摘链球菌 mutans,一个克积极的容许的厌氧的细菌,被认为是为牙齿的龋的一个主要 etiological 因素。在 thisstudy,从龋活跃、没有龋的个人的牙齿的瓷釉表面的匾为 S 被获得并且栽培。mutans 隔离。形态学检查,生物化学的描述,和聚合酶链反应被执行到识别。mutans。S 的 cariogenicity。从临床的标本孤立的 mutans 种类被测试细菌的 acidogenicity, aciduricity,细胞外的 polysaccharideproduction,和粘附能力评估。最后,减少性的 SELEX (由 exponentialenrichment 的 ligands 的系统的进化) 指向整个未经触动的房间的技术与 highcariogenicity 为对种类特定的 ssDNA aptamers 习惯于屏幕。在九轮减少性的 SELEX 以后,足够的水池丰富是由放射性的 isotopeanalysis 出现被完成。充实的水池随机被克隆并且定序,由联机的 MEME 和 RNA 结构软件 analysisof 列在后面序列。从流动 cytometry 的结果显示了那 aptamers H1, H16, H4, L1, L10,和 H19 能 discriminatehighly cariogenic S。mutans 紧张从糟糕, cariogenic 拉紧。在这些之中, Aptamer H19 与 cariogenic S 有最强壮的有约束力的能力。有 69.45 的一个分离常数的 mutans 紧张 ? 畣慬? 敭档湡獩獭漠 ??? 湡 ? 桴 ? 潰整瑮慩? 敮 ? 桴牥灡略楴? 瑳慲整楧獥潦 ? 桴 ? 牴慥浴湥 ? 景琠楨?湩敦瑣潩 | Wei Cui Jiaojiao Liu Donghua Su Danyang Hu Shuai Hou Tongnan Hu Jiyong Yang Yanping Luo Qing Xi Bingfeng Chu Chenglong Wang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，6： | 3 |
| 3 | Surface disorder engineering in ZnCdS for cocatalyst free visible light driven hydrogen production显示文摘Metal chalcogenide solid solution,especially ZnCdS,has been intensively investigated in photocatalytic H_(2) generation due to their cost-effective synthetic procedure and adjustable band structures.In this work,we report on the defect engineering of ZnCdS with surface disorder layer by simple room temperature Li-ethylenediamine(Li-EDA)treatment.Experimental results confirm the formation of unusual Zn and S dual vacancies,where rich S vacancies(Vs)served as electron trapping sites,meanwhile Zn vacancies(Vzn)served as hole trapping sites.The refined structure significantly facilitates the photo charge carrier transfer and improves photocatalytic properties of ZnCdS.The disordered ZnCdS shows a highest photocatalytic H_(2) production rate of 33.6 mmol·g^(-1)·h^(-1) under visible light with superior photocatalytic stabilities,which is 7.3 times higher than pristine ZnCdS and 7 times of Pt(1 wt.%)loaded ZnCdS. | Enna Ha Shuhong Ruan Danyang Li Yuanmin Zhu Yanping Chen Jiangyuan Qiu Zhaohui Chen Tingting Xu Jingyun Su Luyang Wang Junqing Hu | 2022 | Nano Research2022，15，2： | 3 |
| 4 | Effect of strain on DRX of 7050 aluminum alloy during extrusion at high temperature显示文摘Extrusion experiments with different filling contents at the temperature of 440 ℃ were conducted for solution treated 7050 aluminum alloy.The microstructure of typical regions with different filler contents were described qualitatively and characterized quantitatively by electron backscattered diffraction technique(EBSD) and TEM.Fraction of deformed structure decrease continuously since ε=0.72.Second phase particles distribute dispersively and interact with dislocations when ε=0.66,which delays the occurrence of DRX.As the strain increases,particles dissolve into the matrix,and their number reduces rapidly.The influence of particles on dislocation accumulation is impaired,so dislocations accumulate on the subgrain boundaries continuously,and lead to the transformation of subgrain boundaries into high angle grain boundaries(HAGBs).The continuous dynamic recrystallization(CDRX) occurrs at the strain of 0.81~0.85.At ε=0.92,CDRX convert rapidly with the increase of HAGBs fraction.But the size of CDRX grains is deduced to be minimum 3.3 μm by theoretical analysis,and it is obtained from experimental result that the maximal size of CDRX is 5.3 μm. | ZHU Danyang,ZHEN Liang,HU Wenhao,CHEN Junzhou,CUI Yuexian,and SHAO Wenzhu School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 3 |
| 5 | Understanding the relationships between poverty alleviation and ecosystem conservation:empirical evidence from western China显示文摘Despite growing interest in the use of Payments for Ecosystem Services(PES)for both social and ecological benefits,few studies have investigated the feedback and interaction between poverty alleviation and ecosystem protection outcomes.In this study,the poverty reduction effects of PES policies and their subsequent influence on environmental protection outcomes are investigated.To address these questions,222 local rural households who were involved in PES programs from the Habahu National Nature Reserve in western China were interviewed.The results showed that the social and ecological outcomes of PES policies are neither two separate entities nor a trade-off.While rural households are the key participants in PES programs,the social and ecological outcomes of PES policies are closely related to each other.In addition,poverty reduction results could greatly influence ecosystem conservation effects.Livelihood assets,as well as the attitudes of rural households,play important roles in both of the outcomes.This research provides a new perspective that considers the social and ecological benefits of PES policies,and it also calls for an integrated consideration of social and ecological components in tihe design of PES policies to achieve enhanced results both for poverty alleviation and ecosystem conservation. | Xujun HU Huiyuan ZHANG Haiguang HAO Danyang FENG Haiyan LIU Qiang ZHANG | 2020 | Frontiers of Earth Science2020，14，1： | 2 |
| 6 | Molten salt as ultrastrong polar solvent enables the most straightforward pyrolysis towards highly efficient and stable single-atom electrocatalyst显示文摘Currently,pyrolysis as the most widely used method still has some key issues not well resolved for synthesis of carbon-supported single-atom catalysts(C-SACs),e.g.,the sintering of metal atoms at high temperature as well as the high cost and complicated preparations of precursors.In this report,molten salts are demonstrated to be marvellous medium for preparation of C-SACs by pyrolysis of small molecular precursors(ionic liquid).The ultrastrong polarity on one hand establishes robust interaction with precursor and enables better carbonization,resulting in largely enhanced yield.On the other hand,the aggregation of metal atoms is effectively refrained while no nanoparticle or cluster is formed.By this strategy,a C-SAC with atomically dispersed Fe-N_(4) sites and a high specific area over 2000 m^(2) g^(-1) is obtained,which illustrates high ORR activity in both acid and alkaline media.Moreover,this SAC exhibits superior methanol tolerance and stability after acid soaking at 85℃ for 48 h.It is believed that the molten-salts-assisted pyrolysis can be developed into a routine strategy as it not only can largely simply the synthesis of C-SACs,but also can be extended to prepare other types of SACs. | Nannan Li Wei Liu Chao Zhu Ce Hao Jingya Guo Hongyu Jing Jinwen Hu Cuncun Xin Danyang Wu Yantao Shi | 2021 | Journal of Energy Chemistry2021，30，3： | 1 |
| 7 | Thermocline Model for Estimating Argo Sea Surface Temperature Thermocline Model for Estimating Argo Sea Surface Temperature显示文摘Argo has become an important constituent of the global ocean observation system.However,due to the lack of sea surface measurements from most Argo profiles,the application of Argo data is still limited.In this study,a thermocline model was constructed based on three key thermocline parameters,i.e,thermocline upper depth,the thermocline bottom depth,and thermocline temperature gradient.Following the model,we estimated the sea surface temperature of Argo profiles by providing the relationship between sea surface and subsurface temperature.We tested the effectiveness of our proposed model using statistical analysis and by comparing the sea surface temperature with the results obtained from traditional methods and in situ observations in the Pacific Ocean.The root mean square errors of results obtained from thermocline model were found to be significantly reduced compared to the extrapolation results and satellite retrieved temperature results.The correlation coefficient between the estimation result and in situ observation was 0.967.Argo surface temperature,estimated by the thermocline model,has been theoretically proved to be reliable.Thus,our model generates theoretically feasible data present the mesoscale phenomenon in more detail.Overall,this study compensates for the lack surface observation of Argo,and provides a new tool to establish complete Argo data sets. | Chunling Zhang Mengli Zhang Zhenfeng Wang Song Hu Danyang Wang Shenglong Yang | 2022 | Sustainable Marine Structures2022，4，1： | 1 |
| 8 | Friction and Wear Behaviors of a Cylinder Liner–Piston Ring with Emulsified Bio-Oil as Fuel显示文摘 | YuFu Xu HuiQiang Yu XiaoYang Wei Zheng Cui XianGuo Hu Teng Xue DanYang Zhang | 2013 | Tribology Transactions2013，，3： | 1 |
| 9 | A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration显示文摘Bacterial infection and insufficient osseointegration are critical factors affecting the long-term success of titanium-based implants.Unfortunately,the direct application of antibiotic on Ti implants easily leads to poor cytocompatibility,as well as the production of drug-resistant bacteria.So,in this work,we designed a prospective antibacterial strategy by combining photothermal and ciprofloxacin(CIP).The synergistic effect of photothermal and antibiotic may provide an effective bacteriostatic efficacy without sacrificing osteogenesis at a mild condition of moderate temperature and less antibiotic.Herein,CIP was loaded into mesoporous polydopamine(MPDA)nanoparticles(MPDA@CIP),which were anchored on the surface of titanium and finally covered with sodium hyaluronate-catechol(HAc)coating.The hydrophilic HAc layer could inhibit the early adhesion of bacteria,and some bacteria could secrete bacterial hyaluronidase to accelerate the degradation of HAc.This enabled smart enzyme-triggered release of antimicrobials at the site of infection on-demand and avoided unwanted side effects on normal tissues.In addition,NIR light irradiation had a positive influence on both CIP release and MPDA nanoparticle’s photothermal effect.Moreover,before anchoring MPDA@CIP,by the construction of hydroxyapatite microstructure on Ti sur-face with micro-arc oxidation and alkali heat treatment,the ability of bone formation of Ti could be promoted also.Both in vitro as well as in vivo assays demonstrated that functional Ti has an excellent antibacterial effect and osteogenic ability. | Dan Li Danyang Wang Ye He Bailong Tao Xiaoxia Liu Yulu Yang Lu Tan Yuchen Zhang Jingwei Hu Weihu Yang Yu Tang Kaiyong Cai | 2023 | Journal of Materials Science & Technology2023，，12： | 0 |
| 10 | 2-22 Elastic Scattering Studies of Light Proton-rich显示文摘The elastic scattering is an important probe to study the properties of a nucleus. An accurate measurement ofthe elastic scattering differential cross section is very important to determine the optical potential parameters andthe so-called one quarter angle (q1=4). Also, the optical potential parameters of stable nuclei and unstable nucleiare found to be different. 8B, the binding energy of the last proton is only 0.137 MeV, is a well-known protonhalonucleus even there are still some arguments. Many investigations have been done for 8B by measuring thetotal reaction cross sections, breakup cross section and inelastic scattering differential cross section. However, theexperimental data of elastic scattering of 8B and other light proton-rich nuclei on heavy target are few. Therefore, aseries of experiments have been carried out for such nuclei at the Radioactive Ion Beam Line in Lanzhou (RIBLL). | Wang Jiansong Yang Yanyun Wang Qi Pang Danyang Ma Junbing Huang Meirong Ma Peng Jin Shilun Han Jianlong Bai Zhen Ma Weihu Zhou Yuanjie Chen Jie Jin Lei Chen Jiangbo Hu Qiang R. Wada S. Mukherjee | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice显示文摘Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is inadequate.In addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely uncharacterized.Herein we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPL^(Glu))to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HL^(Glu)),driving allodynia in mouse models of chronic pain.Optogenetic inhibition of this VPL^(Glu)→S1HL^(Glu)circuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control mice.In addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2)were increased in VPL^(Glu)neurons under conditions of chronic pain.Using in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPL^(Glu)neurons abrogated the rise in S1HL^(Glu)neuronal activity while alleviating allodynia in mice with chronic pain.With these data,we propose that dysfunction in HCN2 channels in the VPL^(Glu)→S1HL^(Glu)thalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain. | Jun-Ma Yu Rui Hu Yu Mao Yingju Tai Sen Qun Zhi Zhang Danyang Chen Yan Jin | 2023 | National Science Review2023，10，2： | 0 |
| 12 | Inter-Data Commonality Detection for Spectrum Monitoring in Wireless Sensor Networks显示文摘Cooperative spectrum monitoring with multiple sensors has been deemed as an efficient mechanism for improving the monitoring accuracy and enlarging the monitoring area in wireless sensor networks.However,there exists redundancy among the spectrum data collected by a sensor node within a data collection period,which may reduce the data uploading efficiency.In this paper,we investigate the inter-data commonality detection which describes how much two data have in common.We define common segment set and divide it into six categories firstly,then a method to measure a common segment set is conducted by extracting commonality between two files.Moreover,the existing algorithms fail in finding a good common segment set,so Common Data Measurement(CDM)algorithm that can identify a good common segment set based on inter-data commonality detection is proposed.Theoretical analysis proves that CDM algorithm achieves a good measurement for the commonality between two strings.In addition,we conduct an synthetic dataset which are produced randomly.Numerical results shows that CDM algorithm can get better performance in measuring commonality between two binary files compared with Greedy-String-Tiling(GST)algorithm and simple greedy algorithm. | Zhijuan Hu Danyang Wang Chenxi Li Tingting Wang | 2020 | China Communications2020，17，2： | 0 |
| 13 | Experimental Study of the Elastic Scattering and Breakup Reactions of Proton Drip-line Nucleus^(8)B on^(208)Pb at energies around Four Times of Coulomb Barrier显示文摘First measurement of the angular distribution of breakup reaction for^(8)B on a^(208)Pb target at an energy around four times of Coulomb barrier was carried out at the National Laboratory of Heavy Ion Research of Institute of Modern Physics. | Wang Kang Yang Yanyun Duan Fangfang Pang Danyang Wang Jiansong Gao Zhihao Ma Peng Xu Shiwei Liu Xingquan Ma Junbing Bai Zhen Hu Qiang Jin Shuya Sun Zhiyu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 14 | Experimental Study of the Elastic Scattering of^(10)Be on^(208)Pb at the Energy around Three Times of the Coulomb Barrier显示文摘Elastic scattering is the simplest nuclear process and has been widely used to investigate the structure of the interacting nuclei[1,2]. | Duan Fangfang Yang Yanyun Pang Danyang Hu Bitao Wang Jiansong Wang Kang Yang Guo Valdir Guimaraes Ma Peng Xu Shiwei Liu Xingquan Ma Junbing Bai Zhen Hu Qiang Shu Jinya Sun Xinxin Yao Jiasheng Qi Hangkai Sun Zhiyu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 15 | Enhanced fluorescence sensing of tetracycline with Ti_(2)C quantum dots显示文摘Ti_(2)C quantum dots(QDs)with rich surface functional groups have been synthesized using a hydrothermal method,and used to detect tetracycline(Tc)based on enhanced fluorescence.The interaction between the surface functional groups of Ti_(2)C QDs and Tc enhanced the fluorescence of Tc at 514 nm,which is used to detect Tc quickly and accurately.Under optimal conditions,the fluorescence intensity was linear to the concentration of Tc in the range of 50.0–30.0μM,with a detection limit of 21.6 nM.Furthermore,the Tc-Ti_(2)C QDs detection system was evaluated for detection of Tc in milk and artificial urine.This study demonstrates a new and simple strategy for Tc detection,which is important for food safety and human health. | Dejia Hu ShangZuo Jiang Tianhao Xia Danyang Xiao Yan Li Yanbing Hou Jin Zhong Zhang Ying-Chih Pu | 2024 | Nano Research2024，17，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员