|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inflammatory bowel disease:Epidemiology,pathology and risk factors for hypercoagulability显示文摘Hypercoagulability observed in patients with inflammatory bowel diseases(IBD)may lead to thromboembolic events(TE),which affect the venous and arterial systems alike and are an important factor in patients’morbidity and mortality.The risk of TE in IBD patients has been demonstrated to be approximately threefold higher as compared to the general population.The pathogenesis of thrombosis in IBD patients is multifactorial and not fully explained.The most commonly listed factors include genetic and immune abnormalities,disequilibrium between procoagulant and anticoagulant factors,although recently,the role of endothelial damage as an IBD-triggering factor is underlined.Several studies report that the levels of some coagulation enzymes,including fibrinogen,factorsⅤ,Ⅶ,Ⅷ,active factorⅪ,tissue factor,prothrombin fragment 1+2and the thrombin-antithrombin complex,are altered in IBD patients.It has been demonstrated that there is a significant decrease of tissue plasminogen activator level,a marked increase of plasminogen activator inhibitor type 1 and thrombin-activable fibrinolysis inhibitor,a significantly lower level of antithrombinⅢand tissue factor pathway inhibitor.IBD patients have been also observed to produce an increased amount of various anticoagulant antibodies.Hyperhomocysteinemia,which is a potential risk factor for TE was also observed in some IBD patients.Further studies are necessary to assess the role of coagulation abnormalities in IBD etiology and to determine indications for thromboprophylactic treatment in patients at high risk of developing TE. | Danuta Owczarek Dorota Cibor Mikolaj K Glowacki Tomasz Rodacki Tomasz Mach | 2014 | World Journal of Gastroenterology2014，20，1： | 16 |
| 2 | IL28B polymorphism as a predictor of antiviral response in chronic hepatitis C显示文摘AIM:To evaluate the effect of single nucleotide polymorphisms of interleukin(IL)-28B,rs12979860 on progression and treatment response in chronic hepatitis C.METHODS:Patients(n = 64;37 men,27 women;mean age,44 ± 12 years) with chronic hepatitis C,genotype 1,received treatment with peg-interferon plus ribavirin.Genotyping of rs12979860 was performed on peripheral blood DNA.Histopathological assessment of necroinflammatory grade and fibrosis stage were scored using the METAVIR system on a liver biopsy sample before treatment.Serum viral load,aminotransferase activity,and insulin level were measured.Insulin resistance index,body mass index,waist/hip ratio,percentage of body fat and fibrosis progression rate were calculated.Applied dose of interferon and ribavirin,platelet and neutrophil count and hemoglobin level were measured.RESULTS:A sustained virological response(SVR) was significantly associated with IL28B polymorphism(CC vs TT allele:odds ratio(OR),25;CC vs CT allele:OR,5.4),inflammation activity(G < 1 vs G > 1:OR,3.9),fibrosis(F < 1 vs F > 1:OR,5.9),platelet count(> 200 × 10 9 /L vs < 200 × 10 9 /L:OR,4.7;OR in patients with genotype CT:12.8),fatty liver(absence vs presence of steatosis:OR,4.8),insulin resistance index(< 2.5 vs > 2.5:OR,3.9),and baseline HCV viral load(< 10 6 IU/mL vs > 10 6 IU/mL:OR,3.0).There was no association with age,sex,aminotransferases activity,body mass index,waist/hip ratio,or percentage body fat.There was borderline significance(P = 0.064) of increased fibrosis in patients with the TT allele,and no differences in the insulin resistance index between groups of patients with CC,CT and TT alleles(P = 0.12).Spearman's rank correlation coefficient between insulin resistance and stage of fibrosis and body mass index was r = 0.618 and r = 0.605,respectively(P < 0.001).Significant differences were found in the insulin resistance index(P = 0.01) between patients with and without steatosis.Patients with the CT allele and absence of a SVR had a higher incidence of requiring threshold dose reduction of interferon(P = 0.07).CONCLUSION:IL28B variation is the strongest host factor not related to insulin resistance that determines outcome of antiviral therapy.Baseline platelet count predicts the outcome of antiviral therapy in CT allele patients. | Andrzej Ciela Monika Bociaga-Jasik Iwona Sobczyk-Krupiarz Mikolaj K Glowacki Danuta Owczarek Dorota Cibor Marek Sanak Tomasz Mach | 2012 | World Journal of Gastroenterology2012，18，35： | 4 |
| 3 | Chronic intake of potato chips in humans increases the production of reactive oxygen radicals by leukocytes and increases plasma C- reactive protein: a pilot study 显示文摘 | Marek N Danuta ZD Anita K | 2009 | Am J Clin Nuty2009，89，3： | 1 |
| 4 | Sorption of Bile Acids and Cholesterol by Dietary Fiber of Carrots,Cabbage and Apples显示文摘 | Danuta G Jozef K | 2002 | Food Science and Technology2002，5，： | 1 |
| 5 | Metal contamination of farming soils affected by industry显示文摘 | Krzysztof L Danuta W Irena K | 2004 | Environment International2004，30，： | 1 |
| 6 | Metal contamination of farming soils affected by industry显示文摘 | Krzysztof L Danuta W Irena K | 2004 | Environment International2004，30，： | 1 |
| 7 | The selected determinants of manufacturing postponement within supply chain con- text: an international study 显示文摘 | DANUTA K M ARTUR S | 2011 | International Journal of Production Economics2011，131，1： | 1 |
| 8 | Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells:comparative analysis of phorbol myristateionomycin and phytohemagglutinin stimulation 显示文摘 | Jarolsaw B Danuta K Mariola O | 2001 | Clin Diag Lab Immun2001，8，： | 1 |
| 9 | Bacterial andfungal aerosol in indoor environment in Upper Silesia,Poland显示文摘 | Pastuszka J S Tha Paw U K Danuta 0 L | 2000 | Atmospheric Environment2000，34，22： | 1 |
| 10 | Leptin,thyrotropin,and thyroid hormone in obese/overweight women before and after two levels of energy deficit显示文摘 | Lucyna K Danuta R | 2004 | Endocrine2004，24，2： | 1 |
| 11 | Chemical Composition and Bi- ological Activities of Essential Oil from Salvia sclarea Plants Regenerated in vitro显示文摘 | Lukasz K Danuta K Marek R | 2009 | Molecules2009，14，： | 1 |
| 12 | Construction of predictive models of growth of microorganisms in salted and cured meat products显示文摘 | KATARZYNA K DANUTA K K | 2006 | Innova- tive Food Science and Emerging Technologies2006，7，12： | 1 |
| 13 | 患家族性高胆固醇血症男性和女性颈动脉斑块形成的危险因素是否相同?显示文摘低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)水平升高是家族性高胆固醇血症(familial hypercholesterolemia,FH)患者早期冠状动脉性心脏病(coronary heart disease,CHD)和死亡的主要原因。然而其对男性和女性的影响是否相同尚不确定。为了比较男性和女性FH患者颈动脉斑块(作为冠状动脉粥样硬化可靠的替代指标)的危险因素, | 刘莉 叶鹏 Malgorzata WM Danuta C Malgorzata KB Wiktoria W Maria K Maciej T | 2017 | 中华高血压杂志2017，25，8： | 1 |
| 14 | The selected determinants of manufacturing postponement within supply chain context:aninternational study显示文摘 | Danuta K M Artur S | 2011 | International Journal of Production Economics2011，133，1： | 1 |
| 15 | New achievements in resafepolyur ethane fomas显示文摘 | Zbigniew K Danuta K Wojeieeh | 2002 | Designed Monomers and Polymers2002，5，2： | 1 |
| 16 | Plasminogen activators(tPA and u- PA )and plasminogen activators inhibitors (PAI- 1 and PAI-2) in some myeloproliferative syndromes 显示文摘 | Danuta R Elzbieta K N Grazyna G | 2000 | Med Sci Monit2000，6，4： | 1 |
| 17 | Are polymorphisms in non-coding regions of porcine MyoD genes suitable for predicting meat and fat deposition in the carcass? 显示文摘 | Jolanta K Wojciech K Danuta C | 2002 | Animal Science Papers and Reports2002，20，4： | 1 |
| 18 | Susceptibilities of Neonatal Respiratory Isolates of Ureaplasma urealyticum to Antimicrobial Agents显示文摘 | Anne M Cecilia T Danuta K | 1988 | Antimicrobial Agents and Chemotherapy1988，5，42： | 1 |
| 19 | Constituents of the essential oils of four micropropagated Solidago species显示文摘 | DANUTA K BARBARA T | 2004 | Flavour Fragr J2004，19，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员