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| 1 | Exposure to trace levels of metals and fluoroquinolones increases inflammation and tumorigenesis risk of zebrafish embryos显示文摘Exposure to trace-level heavy metals and antibiotics may elicit metabolic disorder,alter protein expression,and then induce pathological changes in zebrafish embryos,despite negligible physiological and developmental toxicity.This study investigated the single and combined developmental toxicity of fluoroquinolones(enrofloxacin[ENR]and ciprofloxacin[CIP])(0.5 mM)and heavy metals(Cu and Cd)(0.5 mM)to zebrafish embryos,and molecular responses of zebrafish larvae upon exposure to the single pollutant(0.2 mM)or a binary metal-fluoroquinolone mixture(0.2 mM).In all single and mixture exposure groups,no developmental toxicity was observed,but oxidative stress,inflammation,and lipid depletion were found in zebrafish embryos,which was more severe in the mixture exposure groups than in the single exposure groups,probably due to increased metal bioaccumulation in the presence of ENR or CIP.Metabolomics analysis revealed the up-regulation of amino acids and down-regulation of fatty acids,corresponding to an active response to oxidative stress and the occurrence of inflammation.The up-regulation of antioxidase and immune proteins revealed by proteomics analysis further confirmed the occurrence of oxidative stress and inflammation.Furthermore,the KEGG pathway enrichment analysis showed a significant disturbance of pathways related to immunity and tumor,indicating the potential risk of tumorigenesis in zebrafish larvae.The findings provide molecular-level insights into the adverse effects of heavy metals and antibiotics(especially in chemical mixtures)on zebrafish embryos,and highlight the potential ecotoxicological risks of trace-level heavy metals and antibiotics in the environment. | Dantong Jia Ruijie Zhang Jian Shao Wei Zhang Leilei Cai Weiling Sun | 2022 | Environmental Science and Ecotechnology2022，，2： | 1 |
| 2 | Antibiotics in global rivers显示文摘Antibiotics have received extensive attention due to their sophisticated effects on human health and ecosystems.However,there is an extreme scarcity of information on composition,content,geographic distribution,and risk of riverine antibiotics at a large spatial scale.Based on a systematic review of over 600 pieces of literature(1999-2021),we established a global dataset containing more than 90,000 records covering 169 antibiotics and their metabolites in surface water and sediment across 76 countries.The occurrence of prioritized antibiotics largely depended on socioeconomic developmental levels,and the current“hotspots”of polluted rivers were found mostly in less developed countries or emerging economies(e.g.,some in Africa,South America,and Asia).By developing the screening protocol for risk-based prioritization of antibiotics,we advanced a rank list of antibiotics for guiding formulation of region-specific strategies,which highlighted the importance of whole life cycle management of antibiotics in health maintenance of the world’s rivers. | Si Li Yi Liu Yang Wu Jingrun Hu Yiqing Zhang Qian Sun Weiling Sun Jiagen Geng Xiaoying Liu Dantong Jia Xiuqi You Dianqing Qi Moran Tang Yitao Lyu Fanguang Kong Leilei Cai Yufan Ai Yichu Wang Jinren Ni | 2022 | National Science Open2022，1，2： | 1 |
| 3 | Role of YES1 signaling in tumor therapy resistance显示文摘YES proto-oncogene 1(YES1)is an SRC family kinase(SFK)that plays a key role in cancer cell proliferation,adhesion,invasion,survival,and angiogenesis during tumorigenesis and tumor development.Reports suggest that YES1 amplification is associated with resistance to chemotherapeutic drugs and tyrosine kinase inhibitors(TKIs)in human malignancies.However,the mechanisms of drug resistance have not been fully elucidated.In this article,we review the literature on YES1 and discuss the implications of YES1 signaling for targeted therapy and chemotherapy resistance in malignancies.Moreover,recent advances in targeted therapy for YES1-amplified malignancies are summarized.Finally,we conclude that targeting YES1 may reverse drug resistance and serve as a valuable tumor treatment strategy. | Hai Zhou Dantong Sun Junyan Tao Mingjin Xu Xiaochun Zhang Helei Hou | 2023 | Cancer Innovation2023，2，3： | 0 |
| 4 | PD-L1 blockade by immune checkpoint inhibitors impairs sensitivity to osimertinib in EGFR-mutant non-small cell lung cancer cells显示文摘In recent years,the management of advanced nonsmall cell lung cancer(NSCLC)with epidermal growth factor receptor(EGFR)mutation has developed rapidly.Osimertinib is a third generation EGFR tyrosine kinase inhibitor(TKI),which has achieved satisfactory efficacy and tolerability as the first-line(FLARUA study[ref])and second-line(AURA series of studies[ref])treatment of patients with EGFRmutant NSCLC.This suggested that EGFR signaling is involved in the upregulation of programmed cell death ligand 1(PD-L1)expression,which induces apoptosis of T cells,thereby promoting immune escape of tumor cells[1]. | Dantong Sun Puyuan Xing Junling Li | 2022 | Cancer Innovation2022，1，4： | 0 |
| 5 | Drag derived altitude aided navigation method显示文摘The navigation problem of the lifting reentry vehicles has attracted much research interest in the past decade. This paper researches the navigation in the blackout zone during the reentry phase of the aircraft, when the communication signals are attenuated and even interrupted by the blackout zone. However, when calculating altitude, a pure classic inertial navigation algorithm appears imprecise and divergent. In order to obtain a more precise aircraft altitude, this paper applies an integrated navigation method based on inertial navigation algorithms, which uses drag derived altitude to aid the inertial navigation during the blackout zone. This method can overcome the shortcomings of the inertial navigation system and improve the navigation accuracy. To further improve the navigation accuracy, the applicable condition and the main error factors, such as the atmospheric coefficient error and drag coefficient error are analyzed in detail. Then the damping circuit design of the navigation control system and the damping coefficients determination is introduced. The feasibility of the method is verified by the typical reentry trajectory simulation, and the influence of the iterative times on the accuracy is analyzed. Simulation results show that iterative three times achieves the best effect. | Hua SONG Meiling WANG Jing YANG Dantong SUN Longtao KONG Chunling WEI | 2017 | Chinese Journal of Aeronautics2017，30，5： | 0 |
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