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| 1 | Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies显示文摘基于抗体的 PD-1/PD-L1 封锁治疗为癌症在免疫疗法拿了中心舞台,与多重临床的成功。发信号的 PD-1 在肿瘤驱动的 T 房间机能障碍起枢轴的作用。与优先的途径相对照产生或增加肿瘤特定的 T 房间回答,基于抗体的 PD-1/PD-L1 封锁指向导致肿瘤的 T 房间缺点并且恢复先存在调制 antitumor 免疫的 T 房间功能。在这评论,表达式规定和 PD-1 的禁止的函数和基于抗体的 PD-1/PD-L1 封锁治疗的现在的理解上的基本知识简短被总结。我们然后有关 PD-1/PD-Ls 相互作用的结构的基础集中于最近的突破工作并且怎么指向 PD-L1 的治疗学的抗体, pembrolizumab 指向 PD-1 和 avelumab,与 PD-1/PD-L1 的绑定竞争打断 PD-1/PD-L1 相互作用。我们相信这个结构的信息将有益于指向 PD-1 发信号的治疗学的抗体的设计和改进。 | ShuguangTan Danqing Chen Kefang Liu Mengnan He Hao Song Yi Shi Jun Liu Catherine W.-H. Zhang Jianxun Qi Jinghua Yan Shan Gao George F. Gao | 2016 | Protein & Cell2016，7，12： | 8 |
| 2 | Challenges for Implementation of Fair Value Accounting in Emerging Markets: Evidence from China*显示文摘 | XIANJIE HE T.J. WONG DANQING YOUNG | 2011 | Contemporary Accounting Research2011，，2： | 3 |
| 3 | Challenges for Implementation of Fair Value Accounting in Emerging Markets: Evidence from China*显示文摘 | XIANJIE HE T.J. WONG DANQING YOUNG | 2011 | Contemporary Accounting Research2011，，2： | 1 |
| 4 | Challenges for Implementation of Fair Value Accounting in Emerging Markets: Evidence from China*显示文摘 | XIANJIE HE T.J. WONG DANQING YOUNG | 2011 | Contemporary Accounting Research2011，，2： | 1 |
| 5 | Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells显示文摘Adult tendon stem/progenitor cells(TSPCs)are essential for tendon maintenance,regeneration,and repair,yet they become susceptible to senescence with age,impairing the self-healing capacity of tendons.In this study,we employ a recently developed deep-learning-based efficacy prediction system to screen potential stemness-promoting and senescence-inhibiting drugs from natural products using the transcriptional signatures of stemness.The top-ranked candidate,prim-O-glucosylcimifugin(POG),a saposhnikovia root extract,could ameliorate TPSC senescent phenotypes caused by long-term passage and natural aging in rats and humans,as well as restore the self-renewal and proliferative capacities and tenogenic potential of aged TSPCs.In vivo,the systematic administration of POG or the local delivery of POG nanoparticles functionally rescued endogenous tendon regeneration and repair in aged rats to levels similar to those of normal animals.Mechanistically,POG protects TSPCs against functional impairment during both passage-induced and natural aging by simultaneously suppressing nuclear factor-κB and decreasing mTOR signaling with the induction of autophagy.Thus,the strategy of pharmacological intervention with the deep learning-predicted compound POG could rejuvenate aged TSPCs and improve the regenerative capacity of aged tendons. | Yu Wang Shanshan Jin Dan Luo Danqing He Min Yu Lisha Zhu Zixin Li Liyuan Chen Chengye Ding Xiaolan Wu Tianhao Wu Weiran Huang Xuelin Zhao Meng Xu Zhengwei Xie Yan Liu | 2023 | Bone Research2023，11，4： | 0 |
| 6 | A hierarchical bilayer architecture for complex tissue regeneration显示文摘Engineering a complete,physiologically functional,periodontal complex structure remains a great clinical challenge due to the highly hierarchical architecture of the periodontium and coordinated regulation of multiple growth factors required to induce stem cell multilineage differentiation.Using biomimetic self-assembly and microstamping techniques,we construct a hierarchical bilayer architecture consisting of intrafibrillarly mineralized collagen resembling bone and cementum,and unmineralized parallel-aligned fibrils mimicking periodontal ligament.The prepared biphasic scaffold possesses unique micro/nano structure,differential mechanical properties,and growth factor-rich microenvironment between the two phases,realizing a perfect simulation of natural periodontal hard/soft tissue interface.The interconnected porous hard compartment with a Young’s modulus of 1409.00±160.83 MPa could induce cross-arrangement and osteogenic differentiation of stem cells in vitro,whereas the micropatterned soft compartment with a Young’s modulus of 42.62±4.58 MPa containing abundant endogenous growth factors,could guide parallel arrangement and fibrogenic differentiation of stem cells in vitro.After implantation in critical-sized complete periodontal tissue defect,the biomimetic bilayer architecture potently reconstructs native periodontium with the insertion of periodontal ligament fibers into newly formed cementum and alveolar bone by recruiting host mesenchymal stem cells and activating the transforming growth factor beta 1/Smad3 signaling pathway.Taken together,integration of self-assembly and microstamping strategies could successfully fabricate a hierarchical bilayer architecture,which exhibits great potential for recruiting and regulating host stem cells to promote synergistic regeneration of hard/soft tissues. | Min Yu Dan Luo Jing Qiao Jiusi Guo Danqing He Shanshan Jin Lin Tang Yu Wang Xin Shi Jing Mao Shengjie Cui Yu Fu Zixin Li Dawei Liu Ting Zhang Chi Zhang Zhou Li Yongsheng Zhou Yan Liu | 2022 | Bioactive Materials2022，7，4： | 0 |
| 7 | An extended analysis of cardiovascular benefits of indoor air filtration intervention among elderly:a randomized crossover trial(Beijing indoor air purifier study,BIAPSY)显示文摘Objective Evidence on potential cardiovascular benefits of personal-level intervention among the elderly exposed to high levels of particulate matter(PM)remains limited.We aimed to assess improvements in surrogate markers of cardiovascular injury in vulnerable populations at risks by using indoor air filtration units.Methods We conducted a randomized crossover trial for 2 separate 2-week air filtration interventions in 20 households of patients with stable chronic obstructive pulmonary disease and their partners in the winter of 2013,with concurrent measurements of indoor PM.The changes in biomarkers indicative of cardiac injury,atherosclerosis progression and systemic inflammation following intervention were evaluated using linear mixed-effect models.Results In the analysis,average levels of indoor PM with aerodynamic diameters<2.5µm(PM2.5)decreased significantly by 59.2%(from 59.6 to 24.3µg/m3,P<0.001)during the active air filtration.The reduction was accompanied by improvements in levels of high-sensitivity cardiac troponin I by−84.6%(95%confidence interval[CI]:−90.7 to−78.6),growth differentiation factor-15 by−48.1%(95%CI:−31.2 to−25.6),osteoprotegerin by−65.4%(95%CI:−56.5 to−18.7),interleukin-4 by−46.6%(95%CI:−62.3 to−31.0)and myeloperoxidase by−60.3%(95%CI:−83.7 to−3.0),respectively.Conclusion Indoor air filtration intervention may provide potential cardiovascular benefits in vulnerable populations at risks. | Jie Chen Tong Wang Hongbing Xu Yutong Zhu Yipeng Du Beibei Liu Qian Zhao Yi Zhang Lingyan Liu Ningman Yuan Jiakun Fang Yunfei Xie Shuo Liu Rongshan Wu Danqing Shao Xiaoming Song Bei He Bert Brunekreef Wei Huang | 2022 | Global Health Journal2022，6，1： | 0 |
| 8 | Control of polymorphism in solution-processed organic thin film transistors by self-assembled monolayers显示文摘Polymorphism of organic semiconductor films is of key importance for the performance of organic thin film transistors(OTFTs).Herein,we demonstrate that the polymorphism of solution-processed organic semiconductors in thin film transistors can be controlled by finely tuning the surface nanostructures of substrates with self-assembled monolayers(SAMs).It is found that the SAMs of 12-cyclohexyldodecylphosphonic acid(CDPA)and 12-phenyldodecylphosphonic acid(Ph DPA)induce different polymorphs in the dip-coated films of 2-dodecyl[1]benzothieno[3,2-b][1]benzothiophene(BTBT-C12).The film of BTBT-C12 on CDPA exhibits field effect mobility as high as 28.1 cm2 V-1 s-1 for holes,which is higher than that of BTBT-C12 on Ph DPA by three times.The high mobility of BTBT-C12 on CDPA is attributable to the highly oriented films of BTBT-C12 with a reduced in-plane lattice and high molecular alignment. | Danqing Liu Xu Xiao Zikai He Jingjuan Tan Lei Wang Bowen Shan Qian Miao | 2020 | Science China Chemistry2020，63，9： | 0 |
| 9 | PD-1的FG环是肿瘤免疫检查点治疗中单克隆抗体的“热点”显示文摘文章简介PD-1/PD-L1阻断单克隆抗体(mAbs)已成为肿瘤免疫检查点治疗的中心,识别PD-1单克隆抗体的'热点'将有助于开发下一代长效口服给药制剂。研究人员鉴定了两种PD-1靶向的单克隆抗体——GY-5和GY-14。这两种单克隆抗体主要结合PD-1的FG环,与PD-L1存在多种相互作用。FG环与不同的单克隆抗体结合后,其构象发生了很大的变化。PD-1的糖基化修饰可以在4个潜在的N端糖基化位点中的3个位点上观察到。然而,GY-5和GY-14与PD-1的结合不受糖基化的影响。 | Danqing Chen Shuguang Tan Hao Zhang Haiyuan Wang Weiwu He Rui Shi Zhou Tong Jianhua Zhu Hao Cheng Shan Gao Yan Chai Jianxun Qi Minghui Xiao 严景华 高福 | 2020 | 科学新闻2020，，2： | 0 |
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