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| 1 | Oral frailty and neurodegeneration in Alzheimer’s disease显示文摘Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s disease.Among different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical functions.We briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease neurodegeneration.Several underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral disease.Oral microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease risk.On this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s disease.Therefore,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty. | Vittorio Dibello Madia Lozupone Daniele Manfredini Antonio Dibello Roberta Zupo Rodolfo Sardone Antonio Daniele Frank Lobbezoo Francesco Panza | 2021 | Neural Regeneration Research2021，16，11： | 10 |
| 2 | Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress显示文摘 | Marc Birringer Dennis Lington Silvia Vertuani Stefano Manfredini Daniel Scharlau Michael Glei Michael Ristow | 2010 | Free Radical Biology and Medicine2010，，： | 1 |
| 3 | Quantification of the relative risk of multiple occlusal variables for muscle disorders of the stomatognathic system显示文摘 | Nicola Landi Daniele Manfredini Francesco Tognini | 2004 | J Prosthet Dent2004，92，2： | 1 |
| 4 | Quantification of the relative risk of multiple occlusal variables for muscle disorders of the stomatognathic system显示文摘 | Nicola Landi Daniele Manfredini Francesco Tognini | 2004 | The Journal of Prosthetic Dentistry2004，92，2： | 1 |
| 5 | Arthrocentesis of the temporomandibtflar joint: a proposal for a single- needle technique 显示文摘 | Luca Guarda-Nardini Daniele Manfredini | 2008 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2008，106，4： | 1 |
| 6 | 颞下颌关节紊乱患者静态与动态错(牙合)畸形的发生率:与TMD相关的流行病学调查显示文摘目的:错(牙合)畸形是否是颞下颌关节紊乱病(TMD)的风险因素,目前仍有很大争议。已有研究证明,牙齿的咬合功能与TMD之间并没有很强的联系。即便是有联系,也没有真正地在临床应用。因此,本研究旨在评估静态和动态错(牙合)畸形在TMD患者中的发病率,并将其与文献中所获得的正常人群数据进行比较。材料和方法:本研究纳入了625例TMD患者(75%为女性:年龄平均为34,2±6,7岁,范围25~44岁),根据临床检查-无痛[即:关节盘置换和(或)非疼痛性关节病]、肌肉和(或)颞下颌关节(TMJ)中疼痛与否,可将所有样本分为4组,记录静态和动态的错(牙合)畸形。静态的错(牙合)畸形包括咬合,后牙锁殆,深覆殆,前牙开殆,深覆盖,以及磨牙尖牙的不对称。动态的错(牙合)畸形包括正中/侧方骀干扰,以及从后退接触位(RCP)到最大牙尖交错位(M1)的滑动距离是否大于2mm。采用相关系数母评估每组样本中错(牙合)畸形与TMD疼痛状态之间的关联强度。结果:不同的错(牙合)畸形与TMD疼痛状态之间无显著相关性,磨牙不对称和侧方耠干扰上的φ数值从-0.081~+0.043。TMD人群中错(牙合)畸形的患病率与正常人群的患病率类似。结论:不管TMD患者的疼痛状况如何,TMD患者中静态和动态错(牙合)畸形的发生率与文献中报道的正常人群的发病率相似。因此,口腔全科医师应注意,错(牙合)畸形不应作为TMD的鉴别点。 | Daniele Manfredini Giuseppe Perinetti Edoardo Stellini Bruno Di Leonardo Luca Guarda-Nardini 龚诚 李煌 | 2016 | 中国口腔医学继续教育杂志2016，0，3： | 0 |
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