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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | The severity of pandemic H1N1 in fluenza in the United States,from April to July 2009:a Bayesian analysis显示文摘 | Anne M P Daniela D A The New York City Swine Flu Investigation | 2009 | PLoS Med2009，6，12： | 1 |
| 3 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 4 | The stem cells as a potential treatment for neurodegeneration 显示文摘 | Daniela F Vescovi A L Bottai D | 2007 | Methods Mol Biol2007，399，： | 1 |
| 5 | Man- ufacture of Cheddar cheese from high-pressure-treated whole milk 显示文摘 | Daniela D Voigt John A Donaghy Margaret F Patterson | 2010 | Innovative Food Science and Emerging Technologies2010，，11： | 1 |
| 6 | Signaling through Ras is essential' for Ret oncogene - induced cell dif- ferentiation in PCI2 cells显示文摘 | Daniela Califano D Rizzo CD Alessio A | 2000 | J Biol Chem2000，275，19： | 1 |
| 7 | Effect of high-pressure treatment of milk for cheese manufacture on proteolysis,lipolysis,texture and functionality of Cheddar cheese during ripening显示文摘 | Daniela D Voigt Franois Chevalier John A Donaghy | 2012 | Innovative Food Science&Emerging Technologies2012，13，1： | 1 |
| 8 | A prospective study examining the incidence of bacteriuria and urinary tract in- fection after shock wave lithotripsy with targeted antibiotic prophy- laxis显示文摘 | R John D'A Honey Michael Ordon Daniela | 2013 | The Journal of urology2013，189，21： | 1 |
| 9 | 'Take it up a NOTCH:' Novel strategies for cancer therapy显示文摘 | STEFANIE L M GREGORY A W DANIELA M D | 2012 | Cell Cycle2012，12，2： | 1 |
| 10 | Overview of interleukin-18: more than an interferon-γ inducing factor 显示文摘 | CHARLES A D DANIELA N ADRIAN J P | 1998 | Journal of Leukocyte Biology1998，63，： | 1 |
| 11 | Shelf-life modeling of ready-toeat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，5： | 1 |
| 12 | Protective role of antimannan and anti - aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats 显示文摘 | Flavia D B Maria B Daniela A | 1997 | Infection and Immunity1997，65，8： | 1 |
| 13 | Overview of interleukin-18 ; more than an interferon -y induc-ing factor 显示文摘 | CHARLES A D DANIELA NO VICK ADRIAN J P | 1998 | Journal of Leukocyte Biology1998，63，5： | 1 |
| 14 | Effect of high-pressure treatment of milk for cheese manufacture on pro-teolysis, lipolysis, texture and functionality of Cheddar cheese dur- ing ripening 显示文摘 | Daniela D Voigt Francois Chevalier John A Donaghy | 2012 | Innovative Food Science and Emerging Tech- nologies2012，，13： | 1 |
| 15 | Overview of interleukin-18 ; more than an interferon -y induc-ing factor 显示文摘 | CHARLES A D DANIELA NO VICK ADRIAN J P | 1998 | Journal of Leukocyte Biology1998，63，5： | 1 |
| 16 | Shelf-life modeling of ready-to-eat coconut显示文摘 | Milena S Maria R C Daniela D A | 2003 | International Journal of Food Science and Technology2003，38，： | 1 |
| 17 | Profiling Hsp90 differential expression and the molecular effectsof the Hsp90 inhibitor IPI-504 in high-grade gliomamodels 显示文摘 | Kaijun D Stephen T Daniela A | 2014 | J Neurooncol2014，120，12： | 1 |
| 18 | Assessment of macro and microelement accumulation capability of two aquatic plants 显示文摘 | DANIELA B ANNA A PAUL D T | 2004 | Environmental Pollution2004，130，2： | 1 |
| 19 | Osmotic priming of tomato seeds : effects on germination,field emergence,seedling growth,and fruit yield显示文摘 | Daniela A Kent J B John D H | 1987 | Horticulture Science1987，112，3： | 1 |
| 20 | Electropolymerization of phenothiazine + UV-visible + Fourier transform IR spectroscopy显示文摘 | DANIELA D SCHLERETH ARKADY A KARYAKIN | 1995 | J Electronanal Chem1995，395，： | 1 |
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