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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Correspondence analysis of microarray time-course data in case-control design 显示文摘 | QIHUA TA KLAUS B DANIEL H | 2004 | Journal of Biomedical Informatics2004，37，5： | 1 |
| 3 | TheP l a n n i n g Re s p o n s e t o Ur b a n S e r v i c e S e c t o rGrowth:an International Compar ison显示文摘 | Daniels PW O Connor K Hutton TA | 1991 | Growthand Change1991，22，4： | 1 |
| 4 | A Fuzzy Language显示文摘 | Daniel Sanchez Alvarez Antonio F Gomez Skarme ta | 2004 | Fuzzy Sets and Systems2004，141，： | 1 |
| 5 | ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction executive summary显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | Circulation2004，110，： | 1 |
| 6 | ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction executive summary显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | Circulation2004，110，： | 1 |
| 7 | Biochemistry of coenzyme B12-dependent glycerol and diol dehydratases and organization of the encoding genes显示文摘 | DANIEL R BOBIK TA GOTI'SCHALK G | 1999 | FEMS Microbiology Reviews1999，22，5： | 1 |
| 8 | AHA guide-lines for primary prevention of cardiovascular disease and stroke:2002 update:consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases:American Heart Association Science显示文摘 | Pearson TA Blair SN Daniels SR | | 0，，： | 1 |
| 9 | Determination of apigenin in rat plasma by high-performance liquid chromatography显示文摘 | Darina Romanová Daniel Grancai Beáta Jóēová | 2000 | Journal of Chromatography A2000，870，： | 1 |
| 10 | ACC/A HA guide-lines for the management of patients with ST-elevation myocardial infarction-executive summary:a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction)显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | Circulation2004，110，： | 1 |
| 11 | AHA guide-lines for primary prevention of cardiovascular disease and stroke:2002 update:consensus panel guide to comprehensive risk reduction for adult patients without coronary or other atherosclerotic vascular diseases:American HeartAssociation Science Advisory and Coordinating Committee显示文摘 | Blair SN Daniels SR | 2002 | Circulation2002，106，： | 1 |
| 12 | The Planning Response to Urban Service Sector Growth: An International Comparison 显示文摘 | Daniels PW OpConnor K Hutton TA | 1991 | Growth and Change1991，，： | 1 |
| 13 | ACC /AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction-Executive Summary显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | J Am Coll Cardiol2004，44，： | 1 |
| 14 | ACC/AHA guidelines for the management of patientswith ST-elevation myocardial infarction executive summary显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | Circulation2004，110，： | 1 |
| 15 | AHA guidelines for primary prevention of cardiovascular disease and stroke:2002 update:Consensus Panel guide to comprehensive risk reduction for adult patients without coronary or oher atherosclerotic vas cular diseases:American Heart Association Science Advisory and Coordinating Committee显示文摘 | Pearson TA Blair SN Daniels SR | 2002 | Circulation2002，106，3： | 1 |
| 16 | ACC/AHA Guidelines for the management of patients with ST-elevation myocardial infarctions 显示文摘 | Elliott MA Daniel TA Paul WA | 2004 | JACC2004，44，： | 1 |
| 17 | AHA Guidelines forPrimary Prevention of Cardiovascular bisease and Stroke : 2002Update 显示文摘 | Pearson TA Blair SN Daniel SR | 2004 | Circulation2004，106，3： | 1 |
| 18 | Piwi like RNA-mediated gene silencing 1 gene as a possible major player in gastric cancer显示文摘AIM To establish a permanent piwi like RNA-mediated genesilencing 1(PIWIL1) gene knockout in AGP01 gastric cancer cell line using CRISPR-Cas9 system and analyze phenotypic modifications as well as gene expression alterations.METHODS CRISPR-Cas9 system used was purchased from Dharmacon GE Life Sciences(Lafayette, CO, United States) and permanent knockout was performed according to manufacturer's recommendations. Woundhealing assay was performed to investigate the effect of PIWIL1 knockout on migration capability of cells and Boyden chamber invasion assay was performed to investigate the effect on invasion capability. For the gene expression analysis, a one-color microarray-based gene expression analysis kit(Agilent Technologies, Santa Clara, CA, United States) was used according to the protocol provided by the manufacturer. RESULTS PIWIL1 gene knockout caused a significant decrease in AGP01 migration capacity as well as a significant decrease in cell invasiveness. Moreover, functional analysis based on grouping of all differentially expressed m RNAs identified a total of 35 genes(5 up-regulated and 30 down-regulated) encoding proteins involved in cellular invasion and migration. According to current literature, 9 of these 35 genes(DOCK2, ZNF503, PDE4 D, ABL1, ABL2, LPAR1, SMAD2, WASF3 and DACH1) are possibly related to the mechanisms used by PIWIL1 to promote carcinogenic effects related to migration and invasion, since their functions are consistent with the changes observed(being up-or down-regulated after knockout). CONCLUSION Taken together, these data reinforce the idea that PIWIL1 plays a crucial role in the signaling pathway of gastric cancer, regulating several genes involved in migration and invasion processes; therefore, its use as a therapeutic target may generate promising results in the treatment of gastric cancer. | Taíssa Araújo Andre Khayat Luciana Quintana Danielle Calcagno Ronald Mourao Antonio Modesto Juliana Paiva Adhara Lima Fabiano Moreira Edivaldo Oliveira Michel Souza Moneeb Othman Thomas Liehr Eliana Abdelhay Renata Gomes Sidney Santos Paulo Assumpcao | 2018 | World Journal of Gastroenterology2018，24，47： | 1 |
| 19 | Biochemistry of coenzyme B12-de-pendent glycerol and diol dehydratases and organization of the encoding genes显示文摘 | Bobik TA Gottschalk G | 1998 | Ferms Microbiol Rev1998，22，： | 1 |
| 20 | Correspondence analysis of microarray time-course data in case-control design显示文摘 | Qihua Ta Klaus B Daniel H | 2004 | Journal of Biomedical Informatics2004，37，： | 1 |
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