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| 1 | Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients显示文摘Background Lesion-symptom mapping(LSM)is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome.In clinical practice,patients are commonly evaluated using the National Institutes of Health Stroke Scale(NIHSS),an 11-domain clinical score to quantitate neurological deficits due to stroke.So far,LSM studies have mostly used the total NIHSS score for analysis,which might not uncover subtle structure–function relationships associated with the specific sub-domains of the NIHSS evaluation.Thus,the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure–function relationships that a total score may not reveal.Methods Employing a multivariate technique,LSM analyses were conducted using a sample of 180 patients with NIHSS assessment at 48-hour post-stroke from the ESCAPE trial.The NIHSS domains were grouped into six categories using two schemes.LSM was conducted for each category of the two groupings and the total NIHSS score.Results Sub-score LSMs not only identify most of the brain regions that are identified as critical by the total NIHSS score but also reveal additional brain regions critical to each function category of the NIHSS assessment without requiring extensive,specialised assessments.Conclusion These findings show that widely available sub-scores of clinical outcome assessments can be used to investigate more specific structure–function relationships,which may improve predictive modelling of stroke outcomes in the context of modern clinical stroke assessments and neuroimaging. | Deepthi Rajashekar Matthias Wilms M Ethan MacDonald Serena Schimert Michael D Hill Andrew Demchuk Mayank Goyal Sean P Dukelow Nils Daniel Forkert | 2022 | Stroke & Vascular Neurology2022，7，2： | 7 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 4 | Effect of chemical amendments on ammonia volatilization from poultry litter显示文摘 | Moore P A J Daniel T C Edwards D R | 1995 | Journal of Environmental Quality1995，24，： | 1 |
| 5 | Overview of forming and formability issues for high volume aluminum car body panels显示文摘 | Daniel D Guiglionda G Litalien P | 2006 | Materials Science Forum2006，1，： | 1 |
| 6 | Cold-adapted rhizobia for nitrogen fixation in temperate regions1显示文摘 | DANIELLE P PASCAL D SERGE L | 2003 | Canadian Journal of Botany2003，81，12： | 1 |
| 7 | EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis 显示文摘 | Cecile V Cerretti D P Daniel T O | 2003 | J Cell Biol2003，162，： | 1 |
| 8 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis 显示文摘 | Daniel J Pynsent P B McMinn D J | 2004 | J Bone Joint Surg Br2004，86，2： | 1 |
| 9 | Docetaxel and Estramustine Compared with Mitoxantrone and Prednisone for Advanced Refractory Prostate Cancer显示文摘 | Daniel P Petrylak M D Catherine M | 2004 | N Engl J Med2004，351，： | 1 |
| 10 | Molecular investigation of the Rh C/c polymorphism显示文摘 | Avent N D Daniels G L Martin P G | 1997 | Transfus Med1997，7，1： | 1 |
| 11 | Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase显示文摘 | ZELINSKI D P ZANTEK N D Walker - Daniels J | 2002 | J Cell Biochem2002，85，4： | 1 |
| 12 | Association betweenadministration of hepatitis B vaccine at birth and completion of the hepatitis B and 4 : 3 : 1 : 3 vaccine series 显示文摘 | Yusuf HR Daniels D Smith P | 2000 | JAMA2000，284，： | 1 |
| 13 | The Home as a Workplace:Work- Family Interaction and Psychological Well - Being in Telework 显示文摘 | STANDEN P DANIELS K LAMOND D | 1999 | Journal of Occupational Health Psychology1999，4，4： | 1 |
| 14 | Design of homogeneous,monopegylated erythropoietin analogs with preserved in vitro bioactivlty显示文摘 | Dana L L Daniel H D Stephen P E | 2006 | Cox Exp Hematology2006，34，6： | 1 |
| 15 | The Supreme Mask AirwayTM (LMA): anew neonatal supraglottic device: Compari- son with Classic and ProSeal LMA in a mani- kin显示文摘 | Daniele T Matteo P Nicoletta D | 2012 | Resuscitation2012，，83： | 1 |
| 16 | The representation of the visual field on the cerebral cortex in monkeys 显示文摘 | Daniel P M Whitteridge D | 1961 | Journal of Physiology1961，159，2： | 1 |
| 17 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent P B McMinn D J | 2004 | Journal of Bone and Joint Surgery (Br)2004，86，2： | 1 |
| 18 | Multifractal analysis of soil spatial variability 显示文摘 | Adolfo N D P Daniel G Marco B | 1999 | Agronomy Journal1999，91，6： | 1 |
| 19 | Identification of a new catenin:the tyrosine kinase substrate p120cas associates with E-cadherin complexes显示文摘 | REYNOLDS A B DANIEL J MCCREA P D | 1994 | Mol Cell Biol1994，14，： | 1 |
| 20 | Radiation -Assisted Process Enhancement in Wastewater Treatment 显示文摘 | Daniel E M Thomas D W P E’Junko K’ | 2004 | Journal of Environmental Engineering2004，130，2： | 1 |
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