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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system显示文摘睾丸激素缺乏是普通的在里面有心血管的疾病( CVD )的人,和使随机化的控制安慰剂的试用( RCT )在长期的稳定的咽峡炎在导致锻练的心脏的局部缺血上报导了睾丸激素治疗的有益的效果,功能的锻练能力,最大的氧消费在锻练期间(在长期的心失败( CHF )的 VO 2max)和肌肉力量,一些心血管的风险因素的 Q-T 间隔,和改进弄短。睾丸激素缺乏与不利 CV 风险侧面和死亡被联系。临床、科学的研究提供了机械学的证据支持并且解释 RCT 的调查结果。睾丸激素包括肺的 vasculature 是在冠的发行量和另外的脉管的床以内的快速发作的动脉的血管扩张药并且能减少全面外部全身的脉管的抵抗。证据证明了那睾丸激素调停通过钙隧道封锁(L 钙隧道) 的脉管的反应上的这效果并且刺激钾隧道由直接 nongenomic 机制开。睾丸激素也由刺激超速的钾刺激心脏的 myocytes 的极化操作隧道的电流。睾丸激素改进心脏的输出,功能的锻练能力, VO 2max 和 vagally 调停的动脉的 baroreceptor 在 CHF 的心脏的反射敏感,和另外的机制。独立于心脏的功能上的睾丸激素的利益,睾丸激素替换可以也增加骨胳的肌肉葡萄糖新陈代谢并且提高肌肉发达的力量,能在能力可以包括的功能的锻练贡献改进的两个因素改进了葡萄糖新陈代谢和肌肉力量。睾丸激素由在关键新陈代谢的小径的规章的酶上由 genomic 的联合和葡萄糖举起和胰岛素受体,葡萄糖 transporters,和表示的利用表示的 nongenomic 行动改进葡萄糖利用和类脂化合物新陈代谢包括身体作文,胰岛素电阻,和血胆脂醇过多改进新陈代谢的 CV 风险因素。高密度的脂蛋白胆固醇(高级数据链路控制) 上的效果在研究之间不同因为掉落,升起,或没有在层次的变化被发现了。睾丸激素代替能压制传播支持 inflammatory cytokines 的层次并且刺激有的 interleukin-10 (IL-10 ) 的生产反煽动性并且在有 CVD 的人的 anti-atherogenic 行动。C 反应的蛋白质上的效果都没被检测。clotting 因素上的不利效果都没被检测。RCT 清楚地没表明那睾丸激素在颈动脉 intima 厚度或冠的钙免职改进或不利地影响象减小那样的动脉粥样硬化的代理人标记的任何重要证据。动脉粥样硬化的预防或改善上的睾丸激素的任何效果是可能的在在在睾丸激素 RCT 使用了的 statin 治疗审判和并非月出现的年发生。从长期的流行病学的研究的证据的重量支持在与睾丸激素缺乏对待人的研究在主要不利 CV 事件(权标) 和死亡由减小证实了的保护的效果。睾丸激素被代替了到正常健康范围的 RCT 都没报导向上的一个重要好处或不利效果也没有任何最近的元分析。 | T Hugh Jones Daniel M Kelly | 2018 | Asian Journal of Andrology2018，20，2： | 6 |
| 3 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 4 | Evapotranspiration covers: An innovative approach to remediate and close contaminated sites显示文摘 | KELLY L M DANIELLE N C RICHARD J W | 2003 | Remediation Winter2003，14，1： | 1 |
| 5 | POZ for effect POZ - ZF tran- scription factors in cancer and development显示文摘 | KELLY K F DANIEL J M | 2006 | Trends Cell Biol2006，16，11： | 1 |
| 6 | An improved retrieval of tropospheric nitrogen dioxide from GOME显示文摘 | Randall V M C Kelly J Daniel | 2002 | J Geophys Res2002，，： | 1 |
| 7 | Use of a targeted oncolytic poxvirus, JX-594, in patients with refractory primary or metastatic liver cancer: a phase I trial显示文摘 | Byeong-Ho Park Taeho Hwang Ta-Chiang Liu Daniel Y Sze Jae-Seok Kim Hyuk-Chan Kwon Sung Yong Oh Sang-Young Han Jin-Han Yoon Sook-Hee Hong Anne Moon Kelly Speth Chohee Park Young-Joo Ahn Manijeh Daneshmand Byung Geon Rhee Herbert M Pinedo John C Bell David | 2008 | Lancet Oncology2008，，6： | 1 |
| 8 | POZ for effect--POZ-ZF transcription factors in cancer and development显示文摘 | Kelly K F Daniel J M | 2006 | Trends Cell Biol2006，16，： | 1 |
| 9 | Hypertriglyceridemic waist and newly-diagnosed diabetes among remote-dwellin Indigenous Australians 显示文摘 | Daniel M Paquet C Kelly SJ | 2013 | Ann Hum Biol2013，40，6： | 1 |
| 10 | Evapotranspiration covers: an innovative approach to remediate and close contaminated sites显示文摘 | KELLY L M DANIELLE N G RICHARD J W | 2003 | Remediation Winter2003，，： | 1 |
| 11 | Evapotranspiration covers: an innovative approach to remediate and close contaminated sites显示文摘 | KELLY L M DANIELLE N G RICHARD J W | 2003 | Remediation Journal2003，14，1： | 1 |
| 12 | Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver显示文摘 | Dong-Ju Shin Daniel P Odom Kelly B Scribner Saheli Ghoshal Mary M McGrane | 2002 | Molecular and Cellular Endocrinology2002，，1： | 1 |
| 13 | A Unified Model for Apical Caspase Activation显示文摘 | Kelly M Boatright Martin Renatus Fiona L Scott Sabina Sperandio Hwain Shin Irene M Pedersen Jean-Ehrland Ricci Wade A Edris Daniel P Sutherlin Douglas R Green Guy S Salvesen | 2003 | Molecular Cell2003，，2： | 1 |
| 14 | Nuclear receptor signaling and cardiac energetics显示文摘 | Janice M Huss Daniel P Kelly | 2004 | Circulation Research2004，95，： | 1 |
| 15 | Non-responsive celiac disease in children on a gluten free diet显示文摘BACKGROUND Non-responsive celiac disease(NRCD) is defined as the persistence of symptoms in individuals with celiac disease(CeD) despite being on a gluten-free diet(GFD). There is scant literature about NRCD in the pediatric population.AIM To determine the incidence, clinical characteristics and underlying causes of NRCD in children.METHODS Retrospective cohort study performed at Boston Children’s Hospital(BCH). Children < 18 years diagnosed with CeD by positive serology and duodenal biopsies compatible with Marsh Ⅲ histology between 2008 and 2012 were identified in the BCH’s Celiac Disease Program database. Medical records were longitudinally reviewed from the time of diagnosis through September 2015. NRCD was defined as persistent symptoms at 6 mo after the initiation of a GFD and causes of NRCD as well as symptom evolution were detailed. The children without symptoms at 6 mo(responders) were compared with the NRCD group. Additionally, presenting signs and symptoms at the time of diagnosis of CeD among the responders and NRCD patients were collected and compared to identify any potential predictors for NRCD at 6 mo of GFD therapy.RESULTS Six hundred and sixteen children were included. Ninety-one(15%) met criteria for NRCD. Most were female(77%). Abdominal pain [odds ratio(OR) 1.8 95% confidence interval(CI) 1.1-2.9], constipation(OR 3.1 95%CI 1.9-4.9) and absence of abdominal distension(OR for abdominal distension 0.4 95%CI 0.1-0.98) at diagnosis were associated with NRCD. NRCD was attributed to a wide variety of diagnoses with gluten exposure(30%) and constipation(20%) being the most common causes. Other causes for NRCD included lactose intolerance(9%), gastroesophageal reflux(8%), functional abdominal pain(7%), irritable bowel syndrome(3%), depression/anxiety(3%), eosinophilic esophagitis(2%), food allergy(1%), eating disorder(1%), gastric ulcer with Helicobacter pylori(1%), lymphocytic colitis(1%), aerophagia(1%) and undetermined(13%). 64% of children with NRCD improved on follow-up.CONCLUSION NRCD after ≥ 6 mo GFD is frequent among children, especially females, and is associated with initial presenting symptoms of constipation and/or abdominal pain. Gluten exposure is the most frequent cause. | Gopal Veeraraghavan Amelie Therrien Maya Degroote Allison McKeown Paul D Mitchell Jocelyn A Silvester Daniel A Leffler Alan M Leichtner Ciaran P Kelly Dascha C Weir | 2021 | World Journal of Gastroenterology2021，27，13： | 0 |
| 16 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 17 | 破裂和未破裂颅内动脉瘤栓塞治疗实践标准显示文摘弹簧圈栓塞最初被设计并经美国食品药品监督管理局批准用于治疗显微外科手术夹闭风险高的脑动脉瘤,但目前该方法越来越被认为是颅内动脉瘤的一线治疗方法。动脉瘤血管内治疗技术已有长足进步,新器材的研发使得以前因血管解剖结构复杂而无法填塞的动脉瘤也得以治疗,从而扩大了血管内治疗的适应证。而且,血管内弹簧圈栓塞已成为当前动脉瘤血管内治疗的主流方法;医学文献证明,在特定患者人群中,弹簧圈栓塞的转归优于外科手术夹闭。最近的一份美国心脏协会(AmericanHeartAssociation,AHA)科学声明指出,对于适合治疗的脑动脉瘤,不论是血管内栓塞还是显微外科手术夹闭,均为破裂动脉瘤I级推荐治疗方法和未破裂动脉瘤的11a级推荐治疗方法。在这两组患者中,治疗利大于弊。一个在血管显微神经外科、神经重症监护和介入神经外科方面有着丰富经验的多学科团队最有利于对颅内动脉瘤的处理实施最佳的技术。神经血管联合写作组此前已发表过一份联合声明,提出了有关脑血管介入治疗的培训和认证的推荐意见。 | Athos Patsalides Ketan R Bulsara Daniel P Hsu Todd Abruzzo Sandm Narayanan Mahesh V Jayaraman Gary Duckwiler Richard Paul Klucznik Michael Kelly Joshua A Hirsch Don Heck Jeffery Stmshine Don Frei Michael J Alexander Huy M Do Philip M Meyers 邱忠明(译) 张君(译) 徐格林(译) | 2013 | 国际脑血管病杂志2013，21，6： | 0 |
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