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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort显示文摘BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in humans.AIM To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic profile.METHODS Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap MS.RESULTS Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PNGase F incubation, showing higher PGE2 levels. Moreover,HRMAS analysis indicated that tumor tissue has altered metabolic features vs non-tumor counterparts, presenting increased levels of certain metabolites such as taurine and phosphocholine and lower levels of lactate. In proteomic experiments, we detected an enlarged number of proteins in tumors that are mainly implicated in basic biological functions like mitochondrial activity,DNA/RNA processing, vesicular trafficking, metabolism, cytoskeleton and splicing.CONCLUSION In our colorectal cancer cohort, tumor tissue presents a differential COX-2 expression pattern with lower enzymatic activity that can be related to an altered metabolic and proteomic profile. | Patricia Prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 4 | Three-dimensional proton MR spectroscopic imaging of premature and term neonates 显示文摘 | Daniel BV Barkovich JA Susan MN | 2001 | AJNR2001，22，： | 1 |
| 5 | Molecular analysis of the soluble butane monooxygenase from Pseudomonas butanovora显示文摘 | Miria KS Luis AS Daniel JA | 2002 | Micro- biology2002，，148： | 1 |
| 6 | The hippopathway in human upper gastrointestinal dysplasia and carcinoma: A novel oncogenic pathway显示文摘 | Lain Himlin DM Daniels JA Gayyed MF | 2006 | Int J Gastrointest Cancer2006，37，4： | 1 |
| 7 | Ninety-day toxicity study of sodium monochloroacetate in Sprague-Dawley rats显示文摘 | Daniel FB Robinson M Stober JA | 1991 | Toxicology1991，67，2： | 1 |
| 8 | The transferrin receptorpart 1 : Biology and targeting with cytotjoxic antibodies for the treat-ment of cancer显示文摘 | Daniels TR Delgado T Rpdrigues JA | 2006 | Clin Dev Immunol2006，121，2： | 1 |
| 9 | Counselor and client ver- bal response mode changes during initial counseling session 显示文摘 | Lonborg SD Daniels JA Hammond SG | 1991 | J Counsel Psychol1991，38，4： | 1 |
| 10 | The transferrin recep- tor part I: Biology and targeting with cytotoxic antibodies for the treatment of cancer显示文摘 | Daniels TR Delgado T Rodriguez JA | 2006 | Clin Immunol2006，121，2： | 1 |
| 11 | Paradoxically high adiponectin in obese 16-year-old girls protects against appearance of the metabolic syndrome and its components seven years later 显示文摘 | Morrison JA Glueck C J Daniels S | 2011 | J Pediatr2011，158，2： | 1 |
| 12 | The transferrin receptor and the targeted delivery of therapeutic agents against cancer显示文摘 | Daniels TR Bernabeu E Rodríguez JA | 2012 | Biochim Biophys Acta2012，1820，3： | 1 |
| 13 | Future IVF pregnancy potential of women with variably elevated day 3 FSH levels显示文摘 | Martin JS Daniel SA Nisker JA | 1996 | Fertil Steril1996，65，： | 1 |
| 14 | Chdl chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation 显示文摘 | Pray-Grant MG Daniel JA Schieltz D | 2005 | Nature2005，433，7024： | 1 |
| 15 | Adolescent oligomenorrhea in a biracial schoolgirl cohort:a simple clinical parameter predicting impaired fasting glucose plus type 2 diabetes mellitus,insulin,glucose,insulin resistance,and centripetal obesity from age 19 to 25 years显示文摘 | Morrison JA Glueck CJ Daniels S | | 0，，09： | 1 |
| 16 | Relation of duration of symptoms with response to thrombolytic therapy in pulmonary embolism显示文摘 | Parker JA Patel SR | | Am J Cardiol0，80，1： | 1 |
| 17 | Pre- and postop- erative evaluation of partial anomalous pulmonary venous re- turn: by 3 dimensional cardiovascular magnetic resonance im aging and cardiovascular computed tomngraphy 显示文摘 | Crestanello JA Daniels C Franco V | 2010 | Tex Heart Inst J2010，37，： | 1 |
| 18 | The transferrin receptor part Ⅰ: biology and targeting with cytotoxic antibodies for the treatment of cancer显示文摘 | Daniel TR Delgado T Rodriguez JA | 2006 | Clin Imrnunol2006，121，2： | 1 |
| 19 | Assessment of cardiac stress from massive pulmonary embolism with 12-lead ECG显示文摘 | Daniel KR Courtney DM Kline JA | | 0，，： | 1 |
| 20 | A Practical Criterion for the Rapid Detection of Single‐Loop and Double‐Loop Reentry Tachycardias显示文摘 | NICK W.F. LINTON STEPHEN B. WILTON DANIEL SCHERR ASHOK J. SHAH NICOLAS DERVAL FREDERIC SACHER MATTHEW WRIGHT MéLèZE HOCINI MARK D. O’NEILL MICHEL HA?SSAGUERRE PIERRE JA?S | 2013 | J Cardiovasc Electrophysiol2013，，5： | 1 |
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