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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Computed tomography of urinary calculi显示文摘 | Daniel CA Peter KV Raymond DB | 2005 | Contemp Diagn Radiol2005，28，6： | 1 |
| 3 | Gallbladder wall inflammatory cells in pediatric patients with biliary dyskinesia and cholelithiasis: A pilot study 显示文摘 | Ran B Friesen CA Daniel JF | 2006 | J Pediatr Surg2006，41，9： | 1 |
| 4 | High aluminum concentration and initial establishment of Handroanthus impetiginosus : clues about an Al non-resistant species in Brazilian Cerrado显示文摘Cerrado soils are acidic and nutrient-poor,with high content of solubilized Al 3+.Plants growing in these conditions may display adaptations to cope with high aluminum concentrations especially during early developmental stages.We investigated leaf nutritional status,and photosynthetic and growth characteristics during the initial establishment of Handroanthus impetiginosus(Mart.Ex Dc.)Mattos,a secondary tree species distributed in the Brazilian Cerrado.Our goal was to understand leaf-level traits related to diff erent aluminum concentrations.H.impetiginosus plants were cultivated in four diff erent aluminum sulfate concentrations:0,1,2,and 4 mM Al,for 40 days.We performed analyses of growth,leaf gas exchange,chloroplast pigment content,and leaf mineral nutrients.We observed a linear increase of Al leaf content as a function of Al concentration in the nutrient solution.Plants grown in 1 mM Al showed a remarkable increase of K leaf content,net photosynthesis,stomatal conductance,and transpiration,while in 4 mM Al there were reductions of N,P,and K contents,gas exchange characteristics,and height.H.impetiginosus did not have mechanisms of avoidance,compartmentalization,or resistance to high Al concentrations.Indeed,this species showed a hormetic response,with low Al concentrations stimulating and high Al concentrations inhibiting plant responses. | Ane Marcela das Chagas Mendon ca Jean Marcel Sousa Lira Ana Luiza de Oliveira Vilela Daniel Amorim Vieira Nayara Cristina de Melo Joao Paulo Rodrigues Alves Delfi no Barbosa | 2020 | Journal of Forestry Research2020，31，6： | 1 |
| 5 | Effect of evaporation on C 7 light hydrocarbon parameters显示文摘 | Nora K. Ca?ipa-Morales Carlos A. Galán-Vidal Mario A. Guzmán-Vega Daniel M. Jarvie | 2003 | Organic Geochemistry2003，，6： | 1 |
| 6 | Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matter显示文摘 | Dick CA Singh P Daniels M | 2003 | J Toxicol Environ Health A2003，66，： | 1 |
| 7 | Neuronal nicotinic receptors as analgesic targets: it's a winding road显示文摘 | Umana IC Daniele CA McGehee DS | 2013 | Bioehem Pharmacol2013，86，： | 1 |
| 8 | Risk of scar in the comparison of age-related macular degen- eration treatments trial 显示文摘 | Daniel E Toth CA Grunwald JE Jaffe G J Martin DF Fine SL | 2014 | Ophthalmology2014，121，3： | 1 |
| 9 | Reduction of risk for cardiovas-cular disease in children and adolescents 显示文摘 | Daniels SR Pratt CA Hayman LL | 2011 | Circulation2011，124，15： | 1 |
| 10 | Abortive and productive infections of human mononuclear phagocytes by type I herpes simplex virus显示文摘 | Daniels CA Kleinerman ES Snyderman R | 1978 | Am J Pathol1978，91，： | 1 |
| 11 | Risk of geographic atrophy in the comparison of age-relat- ed macular degeneration treatments trials 显示文摘 | Grunwald JE Daniel E Huang J Ying GS Maguire MG Toth CA | 2014 | Ophthalmology2014，121，1： | 1 |
| 12 | Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells显示文摘 | NIEDERNHOFER L J DANIELS JS ROUZER CA | 2003 | J Biol Chem2003，278，31： | 1 |
| 13 | Low-threshold primary afferent drive onto GABA ergic interneurons in the superficial dorsal horn of the mouse 显示文摘 | Daniele CA AB MacDermott | 2009 | J Neurosci2009，29，： | 1 |
| 14 | Progesterone receptor action:defining a role in breast cancer显示文摘 | Daniel AR Hagan CR Lange CA | | 0，，03： | 1 |
| 15 | Progesterone receptor action: defining a role in breast cancer显示文摘 | Daniel AR Hagan CR Lange CA | 2011 | Expert Rev Endocrinol Metab2011，6，11： | 1 |
| 16 | Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content 显示文摘 | Daniels RW Collins CA Gelfand MV | 2004 | J Neurosci2004，24，10： | 1 |
| 17 | Reduction of risk for cardiovascular disease in children and adolescents显示文摘 | Daniels SR Pratt CA Hayman LL | 2011 | Circulation2011，124，15： | 1 |
| 18 | Modeling analysis of the L (-)-carnitine production process by Escherichia coli显示文摘 | Daniel V Guebel Ne'stor V Torres Manuel Ca'novas | 2006 | Process Biochemistry2006，41，： | 1 |
| 19 | Guidelines for the use and interpretation of assays for monitoring autophagy显示文摘 | Daniel JK Fabio CA Hagai A | 2012 | Autophagy2012，8，4： | 1 |
| 20 | Proliferation of epithelial rests of Malassez during experimental tooth movement 显示文摘 | Talie NF Evans CA Daniel JC | 2003 | Am J Orthod Dentofac Orthop2003，123，5： | 1 |
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