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| 1 | Operative complications and economic outcomes of cholecystectomy for acute cholecystitis显示文摘BACKGROUND Recent management of acute cholecystitis favors same admission(SA)or emergent cholecystectomy based on overall shorter hospital stay and therefore cost savings.We adopted the practice of SA cholecystectomy for the treatment of acute cholecystitis at our tertiary care center and wanted to evaluate the economic benefit of this practice.We hypothesized that the existence of complications,particularly among patients with a higher degree of disease severity,during SA cholecystectomy could negate the cost savings.AIM To compare complication rates and hospital costs between SA vs delayed cholecystectomy among patients admitted emergently for acute cholecystitis.METHODS Under an IRB-approved protocol,complications and charges for were obtained for SA,later after conservative management(Delayed),or elective cholecystectomies over an 8.5-year period.Patients were identified using the acute care surgery registry and billing database.Data was retrieved via EMR,operative logs,and Revenue Cycle Operations.The severity of acute cholecystitis was graded according to the Tokyo Guidelines.TG18 categorizes acute cholecystitis by Grades 1,2,and 3 representing mild,moderate,and severe,respectively.Comparisons were analyzed withχ2,Fisher’s exact test,ANOVA,ttests,and logistic regression;significance was set at P<0.05.RESULTS Four hundred eighty-six(87.7%)underwent a SA while 68 patients(12.3%)received Delayed cholecystectomy.Complication rates were increased after SA compared to Delayed cholecystectomy(18.5%vs 4.4%,P=0.004).The complication rates of patients undergoing delayed cholecystectomy was similar to the rate for elective cholecystectomy(7.4%,P=0.35).Mortality rates were 0.6%vs 0%for SA vs Delayed.Patients with moderate disease(Tokyo 2)suffered more complications among SA while none who were delayed experienced a complication(16.1%vs 0.0%,P<0.001).Total hospital charges for SA cholecystectomy were increased compared to a Delayed approach($44500±$59000 vs$35300±$16700,P=0.019).The relative risk of developing a complication was 4.2x[95%confidence interval(CI):1.4-12.9]in the SA vs Delayed groups.Among eight patients(95%CI:5.0-12.3)with acute cholecystitis undergoing SA cholecystectomy,one patient will suffer a complication.CONCLUSION Patients with Tokyo Grade 2 acute cholecystitis had more complications and increased hospital charges when undergoing SA cholecystectomy.This data supports a selective approach to SA cholecystectomy for acute cholecystitis. | Christopher P Rice Krishnamurthy B Vaishnavi Celia Chao Daniel Jupiter August B Schaeffer Whitney R Jenson Lance W Griffin William J Mileski | 2019 | World Journal of Gastroenterology2019，25，48： | 8 |
| 2 | 光动力疗法治疗非小细胞肺癌显示文摘光动力疗法被越来越多地应用于治疗胸部恶性肿瘤。对于早期非小细胞肺癌(如支气管腔内肺癌)、X线检查阴性或同时性原发癌,光动疗法可作为主要治疗手段进行腔内根治性治疗。作为单一根治疗法,光动力疗法是治疗支气管镜可见≤1 cm且无软骨外浸润的肺部肿瘤的最有效方法。对于晚期非小细胞癌患者,光动力治疗可以作为综合根治疗法的一部分,用于减轻阻塞性支气管内病变,增加可手术性或缩小所需手术范围。本文对现有发表的应用光动力疗法治疗至少10例以上非小细胞肺癌病例的研究文献进行综述,提出了光动力疗法应用的治疗建议并进行了总结。 | Charles B Simone II Joseph S Friedberg Eli Glatstein James P Stevenson Daniel H Sterman Stephen M Hahn Keith A Cengel 袁光金 李金銮 朱宇熹 凌扬 | 2013 | 国际病理科学与临床杂志2013，33，3： | 3 |
| 3 | Reich characterization of a quasi-one dimensional spin -1/2 magnet which is gapless and paramagnetic for gμBH≤J and kBT《J显示文摘 | Hammar P R Stone M B Daniel H | 1999 | Phys Rev B1999，59，2： | 1 |
| 4 | Risk of heparin lock-related bleeding when use indwelling venous cather inhaemodialysis显示文摘 | Huseyin K Pierre P Daniel B | 2001 | Nephrol Dal Transplant2001，16，： | 1 |
| 5 | Making sense of latent TGF 13 activation 显示文摘 | Justin P John S Daniel B | 2003 | Journal of Cell Science2003，116，： | 1 |
| 6 | Microbial hydrolysis of methyl aromatic esters by Burkholderia cepacia iso- lated from soil显示文摘 | Geraldine P Danielle V Jean B | 2001 | FEMS Microbiology Ecology2001，37，： | 1 |
| 7 | Biological and analytical sta- bility of a peripheral blood gene expression score for obstructive coro- nary artery disease in the PREDICT and COMPASS studies 显示文摘 | Daniels SE Beineke P Rhees B | 2014 | Card- iovascTransl Res2014，7，7： | 1 |
| 8 | Toxicity studies of 1,3- dichlorobenzene in Sprague-Dawley rats显示文摘 | McCauley P T Robinson M Daniel F B | 1995 | Drug and Chemical Toxicology1995，18，23： | 1 |
| 9 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis 显示文摘 | Daniel J Pynsent P B McMinn D J | 2004 | J Bone Joint Surg Br2004，86，2： | 1 |
| 10 | Quality of life in stonm patlents显示文摘 | Nugent K P Daniels P Stewart B | 1999 | Dis Colon Rectum1999，42，12： | 1 |
| 11 | Circulating levels of Vasfatin, Resistin and Pro - inflammatery cytokine Interteuken - 8 in acute pancreatitis 显示文摘 | Daniel P Lisniowski B Mokrowiecka A | 2010 | Pancreatology2010，10，4： | 1 |
| 12 | Crystallization of para-Xylene in Scraped-Surface Crystallizers显示文摘 | Daniel B P James B R Hazim A M | 2001 | AICh E J2001，47，11： | 1 |
| 13 | Therapeuticuse of citrulline in cardiovascular disease显示文摘 | MARITZA J R DANIEl H P RUTH B C | 2006 | Cardiovascul Drug Rev2006，24，34： | 1 |
| 14 | Regulation of platelet-derived growth factor receptor expression by cell context overrides regulation by cytokines显示文摘 | Thomas B Ronald S Daniel B P | 1996 | J Cell Physiol1996，169，： | 1 |
| 15 | An extrusion system for the processing of microcellular polymer sheets : Shaping and cell growth control 显示文摘 | Daniel F Baldwin C B Park Nam P Suh | 1996 | Polymer Engineering and Science1996，36，10： | 1 |
| 16 | Tillage effects on soil properties and crop production in the sub-humid and semiarid Argentinean Pampas 显示文摘 | Daniel E B Jose L P Paul W U | 1998 | Soil & Tillage Res1998，49，： | 1 |
| 17 | Metal-on-metal resurfacing of the hip in patients under the age of 55 years with osteoarthritis显示文摘 | Daniel J Pynsent P B McMinn D J | 2004 | Journal of Bone and Joint Surgery (Br)2004，86，2： | 1 |
| 18 | Multifractal analysis of soil spatial variability 显示文摘 | Adolfo N D P Daniel G Marco B | 1999 | Agronomy Journal1999，91，6： | 1 |
| 19 | Identification of a new catenin:the tyrosine kinase substrate p120cas associates with E-cadherin complexes显示文摘 | REYNOLDS A B DANIEL J MCCREA P D | 1994 | Mol Cell Biol1994，14，： | 1 |
| 20 | Numerical evaluation of thermal response tests显示文摘 | Sarah S Simone B Daniel P | 2007 | Geothermics2007，36，2： | 1 |
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