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| 1 | Interventions to improve sarcopenia in cirrhosis: A systematic review显示文摘BACKGROUND Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIM To examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt(TIPS) to improve muscle mass in cirrhosis.METHODS We search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles(RCTs, clinical trial, comparative study)in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTS We identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements.We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSION Although the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings. | Maliha Naseer Erica P Turse Ali Syed Francis E Dailey Mallak Zatreh Veysel Tahan | 2019 | World Journal of Clinical Cases2019，7，2： | 8 |
| 2 | Lower severe hypoglycemia risk: insulin glargine versus NPH insulin in type 2 diabetes显示文摘 | Dailey G Strange P | 2008 | Am J Manag Care2008，14，1： | 1 |
| 3 | Lipid effects of glyburide/metformin tablets in patients with type 2 diabetes mellitus with poor glycemic control and dyslipidemia in an open-label extension study 显示文摘 | DAILEY GE 3RD MOHIDEEN P FIEDOREK F T | 2002 | Clin Ther2002，24，9： | 1 |
| 4 | Pho- tophysical characterization of poly ( p - pyridine ) 显示文摘 | Monkman A P Halim M Dailey S Samuel I D M Horsbrugh L | 1999 | Synthetic Met- als1999，101，： | 1 |
| 5 | Determination of electronic structure of molecules from nuclear quadrupole ef{ects显示文摘 | TOWNES C H DAILEY I3 P | 1949 | The Journal of Chemical Physics1949，17，9： | 1 |
| 6 | The composition of lubricant-derived surface layers formed in a lubricated cam/tappetcontact: effects of adding overbased detergent and dispersant to a simple ZDTP solution 显示文摘 | Willermet P A Dailey D P Carter R O | 1995 | Tribol Int1995，28，： | 1 |
| 7 | 12-Lipoxygenase : classification, possible therapeutic benefits from inhibition, and inhibitors 显示文摘 | Dailey LA Imming P | 1999 | Curt Med Chem1999，6，5： | 1 |
| 8 | 12-Lipoxygenase: classification, possible therapeutic benefits from inhibition, and inhibitors显示文摘 | Dailey L A Imming P | 1999 | Curr Med Chem1999，6，： | 1 |
| 9 | The role of dissolved organic matter bioavailability in promoting phytoplankton blooms in Florida Bay 显示文摘 | Boyer J N dailey S K Gibson P J | 2006 | Hydrobiologia2006，569，： | 1 |
| 10 | Posterior surgical ap- preaches and outcomes in metastatic spine-disease显示文摘 | Klimo P Jr Dailey AT Fessler RG | 2004 | Neuro- surg Clin N Am2004，15，4： | 1 |
| 11 | Identification of a Creactive protein binding site in two hepatic carboxylesterases capable of retaining C-reactive protein within the endoplasmic reticulum显示文摘 | Yue CC Muller-Greven J Dailey P | 1996 | J Biol Chem1996，271，22： | 1 |
| 12 | Mechanism of formation of antiwear films from zinc dialkyl dithiophosphates 显示文摘 | Willermet P A Dailey D P Schmitz P J | | Tribology Intermationa10，28，3： | 1 |
| 13 | The dfect of blade tip geometry on the tip leakage flow in axial turbine显示文摘 | Heyes F J G Hodson H P Dailey G M | 1992 | Journal of Turbomachinery1992，114，3： | 1 |
| 14 | The role of dissolved organic matter bioavailability in promoting phytoplankton blooms in Florida Bay显示文摘 | Boyer J N Dailey S K Gibson P J | 2006 | Hydrobiologia2006，569，1： | 1 |
| 15 | The impor- tance of health information technology in care coordination and transitional care 显示文摘 | CIPRIANO P F BOWLES K DAILEY M | 2013 | Nurs Outlook2013，61，6： | 1 |
| 16 | The Effect of Blade Tip Geometry on the Tip Leakage Flow in Axial Tur- bine Cascades显示文摘 | Heyes F J G Hodson H P Dailey G M | 1992 | Journal of Turbomachineiy1992，114，3： | 1 |
| 17 | Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection显示文摘 | Staprans S I Dailey P J Rosenthal A | 1999 | Virology1999，73，6： | 1 |
| 18 | The role of dissolved organic matter bioavailability in promoting phytoplankton blooms in Florida Bay显示文摘 | BOYER J N DAILEY S K GIBSON P J | 2006 | Hydrobiologia2006，569，： | 1 |
| 19 | Fatigue testing and microscopic evaluation of post and core restorations under artificial crowns 显示文摘 | Gatean P Sabek M Dailey B | 1999 | J Prosthet Dent1999，82，3： | 1 |
| 20 | The effect of blade tip geometry on the tip leakage flow in axial turbine cascades显示文摘 | Heyes F J G Hodson H P Dailey G M | 1992 | Journal of Turbomachinery1992，114，3： | 1 |
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