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| 1 | Enhanced migration of tissue inhibitor of metalloproteinase overexpressing hepatoma cells is attributed to gelatinases: Relevance to intracellular signaling pathways显示文摘AIM: To study the effect of gelatinases (especially MMP-9)on migration of tissue inhibitor of metalloproteinase (TIMP-1) overexpressing hepatoma cells.METHODS: Wild type HepG2 cells, cells stably transfected with TIMP-1 and TIMP-1 antagonist (MMP-9-H401A, a catalytically inactive matrix metalloproteinase (MMP) which still binds and neutralizes TIMP-1) were incubated in Boyden chambers either with or without Galardin (a synthetic inhibitor of MMP-1, -2, -3, -8, -9) or a specific inhibitor of gelatinases.RESULTS: Compared to wild type HepG2 cells, the cells overexpressing TIMP-1 showed 115% migration (P<0.05)and the cells overexpressing MMP-9-H401A showed 62% migration (P<0.01). Galardin reduced cell migration dose dependently in all cases. The gelatinase inhibitor reduced migration in TIMP-1 overexpressing cells predominantly.Furthermore, we examined intracellular signal transduction pathways of TIMP-1-dependent HepG2 cells. TIMP-1deactivates cell signaling pathways of MMP-2 and MMP-9involving p38 mitogen-activated protein kinase. Specific blockade of the ERK pathway suppresses gelatinase expression either in the presence or absence of TIMP-1.CONCLUSION: Overexpressing functional TIMP-1-enhanced migration of HepG2-TIMP-1 cells depends on enhanced MMP-activity, especially MMP-9. | Elke Roeb Anja-Katrin Bosserhoff Sabine Hamacher Bettina Jansen Judith Dahmen Sandra Wagner Siegfried Matern | 2005 | World Journal of Gastroenterology2005，11，8： | 7 |
| 2 | Cyclosporine A, FK-506, 40-0-[2-hydroxyethyl]rapamycin and mycophenolate mofetil inhibit proliferation of human intrahepatic biliary epithelial cells in vitro显示文摘瞄准:调查 cyclosporine 的效果 A (CsA )(MMF ) , FK-506,和 mycophenolate mofetil 和 40-0-[2-hydroxyethyl ] 人的肝内的增长上的 rapamycin (RAD ) 胆汁的上皮细胞(BEC ) 在试管内。方法:BEC 与免疫从六个人的肝织物标本被孤立磁性的分离方法并且与 CsA, FK-506, RAD,和 MMF 在试管内的不同集中对待。房间的增长被 MTT 试金分别地在 24 和 48 h 术后疗法测量。变化的单程的分析被用来分析结果。在 BEC 的 CK 19 的表示被流动血细胞计数和西方的污点监视。结果:BEC 的六根线被建立。他们为 4-18 wk 在试管内幸存。流动血细胞计数分析证明这些房间总是表示了 CK19。CsA, FK-506, RAD,和 MMF 以一种剂量依赖者方式禁止了 BEC 的增长。禁止 BEC (P<0.05 ) 的增长的 CsA, FK-506, RAD,和 MMF 的最低集中分别地是 500, 100, 0.25,和 100 mug/L。然而,由 BEC 的 CK19 的表示没被改变。结论:CsA, FK-506, RAD,和 MMF 在人的肝内 BEC 在试管内上有 antiproliferative 效果,当 RAD 有最强壮的生长禁止的效果时。他们在 transplant 病人的肝新生和胆汁管损害上的可能的效果应该进一步被调查。 | Chao Liu Thomas Schreiter Andrea Frilling Uta Dahmen Christoph E Broelsch Guido Gerken Ulrich Treichel | 2005 | World Journal of Gastroenterology2005，11，48： | 7 |
| 3 | Fatigue behavior of high-entropy alloys: A review显示文摘Fatigue failures cost approximately 4% of the United States' gross domestic product(GDP). The design of highly fatigue-resistant materials is always in demand. Different from conventional strategies of alloy design, high-entropy alloys(HEAs) are defined as materials with five or more principal elements, which could be solid solutions. This locally-disordered structure is expected to lead to unique fatigue-resistant properties. In this review, the studies of the fatigue behavior of HEAs during the last five years are summarized. The four-point-bending high-cycle fatigue coupled with statistical modelling, and the fatigue-crack-growth behavior of HEAs, are reviewed. The effects of sample defects and nanotwins-deformation mechanisms on four-point-bending high-cycle fatigue of HEAs are discussed in detail. The influence of stress ratio and temperature on fatigue-crack-growth characteristics of HEAs is also discussed. HEAs could exhibit comparable or greater fatigue properties, relative to conventional materials. Finally,the possible future work regarding the fatigue behavior of HEAs is suggested. | CHEN PeiYong LEE Chanho WANG Shao-Yu SEIFI Mohsen LEWANDOWSKI John J DAHMEN Karin A JIA HaoLing XIE Xie CHEN BiLin YEH Jien-Wei TSAI Che-Wei YUAN Tao LIAW Peter K | 2018 | Science China(Technological Sciences)2018，61，2： | 3 |
| 4 | Shapes and sizes of nanoscale Pb inclusions in Al显示文摘 | E. Johnson A. Johansen U. Dahmen S. Chen T. Fujii | 2001 | Materials Science & Engineering A2001，，： | 2 |
| 5 | Equilibrium shape and interface roughening of small liquid Pb inclusions in solid Al显示文摘 | H. Gabrisch L. Kjeldgaard E. Johnson U. Dahmen | 2001 | Acta Materialia2001，，20： | 2 |
| 6 | Cubicoids: Modelling and visualization显示文摘 | THAMM-SCHAAR T M | 1993 | Computer AidedGeometric Design1993，10，： | 1 |
| 7 | Is there an advantage in performing a pancreas-preserving total duodenectomy in duodenal adenomatosis 显示文摘 | MUller MW Dahmen R Kninger J | 2008 | Am J Surg2008，195，6： | 1 |
| 8 | Internalhe-mipelvectomy and endoproteticpelvic replacement:long-termfollow-up results显示文摘 | Bruns J Luessenhop SL Dahmen GSR | | 0，，04： | 1 |
| 9 | Job requirements compared to medical school education:differences between graduates from problem-based learning and conventional curricula显示文摘 | Schlett CL Doll H Dahmen J | 2010 | BMC Med Educ2010，10，： | 1 |
| 10 | Shapes and sizes of nanoscale Pb inclusions in Al显示文摘 | Johnson E Johansen A Dahmen U | 2001 | Materials Science & Engineering2001，，： | 1 |
| 11 | A cascadic multigrid algorithm for the Stokes equations显示文摘 | Dietrich Braess Wolfgang Dahmen | 1999 | Numerische Mathematik1999，，2： | 1 |
| 12 | RGD modified polymers: biomaterials for stimulated cell adhesion and beyond 显示文摘 | Hersel U Dahmen C Kessler H | 2003 | Biomaterials2003，24，24： | 1 |
| 13 | RGD modified polymers:biomaterials for stimulated cell adhesion and beyond显示文摘 | Hersel U Dahmen C Kessler H | 2003 | Biomaterials2003，24，： | 1 |
| 14 | Review:Leptin andthe hypothalamo- pituitary-adrenal stress axis显示文摘 | Roubos E W Dahmen M Kozicz T | 2012 | Gen CompEndocrinol’2012，177，： | 1 |
| 15 | Internal limiting membrane peeling with indocyanine green or trypan blue in macular hole surgery a randomized trial显示文摘 | Beutel J Dahmen G Ziegler A | 2007 | Arch Ophthalmol2007，125，： | 1 |
| 16 | Adaptive Wavelet Methods for Elliptic Operator Equations: Convergence Rates 显示文摘 | Cohen A Dahmen W Devore R | 2000 | Math Comp2000，70，3： | 1 |
| 17 | RGD modified polymers: biomaterials for stimulated cell adhesion and beyond显示文摘 | Hersel U Dahmen C Kessler H | 2003 | Biomaterials2003，24，24： | 1 |
| 18 | A statistical framework for model-based image retrieval in medical applications显示文摘 | Keysers D Dahmen J Ney H | 2003 | Journal of Electronic Imaging2003，12，1： | 1 |
| 19 | Compressed sensing and best k-term approximation显示文摘 | Cohen A Dahmen W DeVore R | 2009 | J Amer Math Soc2009，22，： | 1 |
| 20 | Deletions of AXIN1,a component of the WNT/wingless pathway,in sporadic medulloblastomas显示文摘 | Dahmen R P Koch A Denkhaus D | 2001 | Cancer Res2001，61，19： | 1 |
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