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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer显示文摘 | Bochar DA Wang L Beniya H | 2000 | Cell2000，102，2： | 1 |
| 3 | Pixel arrangement of autostereoscopic liquid crystal displays based on parallax barriers显示文摘 | Zhao W X Wang Q H Da H L | 2009 | Molecular Crystals and Liquid Crystals2009，507，1： | 1 |
| 4 | A prospective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma 显示文摘 | Van Poppel H Da Pozzo L Albrecht W | 2007 | Eur Urol2007，51，6： | 1 |
| 5 | Syndrome of insulin resistance in the rat:Inducement by diet and amelioration with benfluorex显示文摘 | Storlien L H Oakes N D Pan DA | 1993 | Diabetes1993，42，： | 1 |
| 6 | Study of the preparation and catalytic performance of molybdenum carbide catalysts prepared with C2H2/H2 carburizing mixture显示文摘 | XIAO T C WANG H T DA J W COLEMAN K S GREEN M L | 2002 | J Catal2002，211，1： | 1 |
| 7 | Radiographics Pattern Recognition of Welding Defects Using Linear Classifiers显示文摘 | R R da Silva M H S Siqueira L P Caloba etc | 2001 | Insight2001，，10： | 1 |
| 8 | A pro- spective randomized EORTC inter-group phase 3 study comparing the complications of elective nephron-sparing surgery and radical nephrectomy for low-stage renal cell carcinoma显示文摘 | Van Poppel H Da Pozzo L Albrecht W | 2007 | Eur Urol2007，51，16： | 1 |
| 9 | Evolution of the social network of scientific collaborations显示文摘 | Barabasi A L Jeong H Néda Z | 1977 | Physica A Statistical Mechanics & Its Applications1977，6，2： | 1 |
| 10 | Hierarchical requirement of SWI/SNF in RB-mediated repression of Plk1显示文摘 | Gunawardena RW Siddiqui H Solomon DA e t a l | 2004 | J Biol Chem2004，279，29： | 1 |
| 11 | A pro-spective randomized EORTC intergroup phase 3 study comparing the complications of elective nephron - sparing surgery and radical nephrectomy for low - stage renal cell carcinoma 显示文摘 | VAN POPPEL H DA POZZO L ALBRECHT W | 2007 | European U- rology2007，51，6： | 1 |
| 12 | Transcription factor glioma - associ- ated oncogene homolog 1 is required for transforming growth fac- tor - betal - induced epithelial - mesenclaymal transition of non -small cell lung cancer cells 显示文摘 | Li H Da L J Fan WD | 2015 | Molecular medicinereports2015，11，5： | 1 |
| 13 | Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars 显示文摘 | Cavanagh CS Chao S Wang BE Huang BE Stephen S Kiani S Forrest K Saintenac C Brown-Guedira GL Akhunova A See D Bai G Pumphrey M Tomar L Wong D Kong S Reynolds M da Silva ML Bockelman H Talbert L Anderson JA Dreisigacker S Baenziger S Carter A Korzun V Morrell PL Dubcovsky J Morell MK Sorrells ME Hayden MJ Akhunov E | 2013 | PNAS2013，110，： | 1 |
| 14 | A prospective,randomised EORTC intergroup phase 3study comparing the oncologic outcome of elective nephronsparing surgery and radical nephrectomy for low-stage renal cell carcinoma显示文摘 | Van Poppel H Da Pozzo L Albrecht W | 2011 | Eur Urol2011，59，4： | 1 |
| 15 | Analysis of appropri- ate timescale for water diversion permits in Brazil显示文摘 | Bof L H Pruski F F Da Silva L M | 2013 | Environ mental Management2013，51，2： | 1 |
| 16 | Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway显示文摘 | Mao Y Da L Tang H | 2011 | Biochem Biophys Res Commun2011，415，： | 1 |
| 17 | Film growth and relationship between microstructure and mechanical properties of a-C: H: F films deposited by PECVD显示文摘 | Maia da Costa M E H Jacobsohn L G | 2001 | Diamond and Related Materials2001，10，： | 1 |
| 18 | Identification of pumpkin populations as resistance sources against the Zucchini yellow virus (ZYMV)显示文摘 | Moura M da C C L Zerbini E M da Silva D J H de Queiroz M A | 2005 | Horticultura Brasileira2005，23，： | 1 |
| 19 | Regeneration of transgenic plants of Prunus armeniaca containing the coat protein gene of Plum Pox Virus显示文摘 | da CAMARA MACHADO M L da CAMARA MACHADO A HANZER V WEISS H REGNER F STEINKELINER H | 1992 | Plant Cell Rep1992，11，： | 1 |
| 20 | Dynamical diseases of brain systems: Different routes to epileptic seizures 显示文摘 | Da Silva F H L Blanes W Kalitzin S N | 2003 | IEEE Trans on Biomed Eng2003，50，5： | 1 |
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