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| 1 | 扁平部玻璃体切除联合经巩膜缝线固定后房型人工晶状体移植的长期效果显示文摘PURPOSE: To investigate the long-term visual outcome and the complication rate following transscleral suture fixation of posterior chamber intraocular lenses (sutured PC-IOLs). DESIGN: A retrospective case-series descriptive study.METHODS: Records of patients who underwent combined pars plana vitrectomy and sutured PC-IOLs at Moorfields Eye Hospital and who had at least 12 months of follow-up were examined for recorded complications. RESULTS: Sixty-one eyes of 48 patients (33 males and 15 females) were identified and included in the analysis, with mean follow-up of 6 years. The mean final best-corrected visual acuity remained at preoperative levels (P=.211) and was largely determined by the underlying ocular pathology before sutured PC-IOL. Overall 30 of 61 (49%) eyes, two or more procedures were performed to reverse a significant peri-or postoperative complication. Breakage of polypropylene sutures was the main indication accounting for 17 of 30 (57%) of those reoperations. Subgroup analysis showed that younger patients were more likely to suffer the above complication (P=.009). The multivariate analysis also showed that longer follow-up was significantly associated with suture breakage (P=.014), with the mean time to breakage approximately 4 years after surgery. CONCLUSIONS: Long-term follow-up of patients undergoing sutured PC-IOLs appears to be associated with a high rate of postoperative complications and significant need for further surgery,which should be discussed during their informed consent process. | Vote B.J. Tranos P. Bunce C. L. Da Cruz 王静波 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，5： | 6 |
| 2 | Visfatin induces oxidative stress in differentiated C2C12 myotubes in an Akt- and MAPK-independent, NF?B-dependent manner显示文摘 | Radu C. Oita Dudley Ferdinando Steve Wilson Christopher Bunce Dawn J. Mazzatti | 2010 | Pflügers Archiv - European Journal of Physiology2010，，4： | 1 |
| 3 | Genetic variation in complement regulators and susceptibility to age-related macular degeneration显示文摘 | Valentina Cipriani Baljinder K. Matharu Jane C. Khan Humma Shahid Chloe M. Stanton Caroline Hayward Alan F. Wright Catey Bunce David G. Clayton Anthony T. Moore John R.W. Yates | 2011 | Immunobiology2011，，2： | 1 |
| 4 | Objectives and Applications of a Statistical Environmental Stratification of Europe显示文摘 | R. H. G. Jongman R. G. H. Bunce M. J. Metzger C. A. Mücher D. C. Howard V. L. Mateus | 2006 | Landscape Ecology2006，，3： | 1 |
| 5 | 适合广大眼科医师操作的简单有效的手术治疗退化性睑内翻显示文摘Objective: To compare the long-term success, recurrence, and complication rate of involutional entropion surgery using the lateral tarsal strip and everting sutures when performed by surgeons in training (resident or fellow) and specialist oculoplastic surgeons (attending supervising physician). Design: Prospective, interventional, comparative, clinical case series. Participants: Adult patients with involutional entropion. Methods: Lateral tarsal strip and everting sutures (LTS+ES) by residents, fellows, or attending supervising physician. A minimum of 12 months of postoperative follow-up was required. Main Outcome Measures: Patients’symptoms and clinical examination to confirm a normal eyelid position (no entropion or secondary ectropion) at rest and with forced orbicularis contraction with the topical amethocaine (tetracaine) test. This test is described. Results: Fifty-five consecutive patients, aged 57 to 91 years (mean, 77 years) underwent LTS+ES surgery on 62 eyelids. Surgery was performed by a consultant ophthalmic oculoplastic surgeon (attending supervising physician) in 8 eyelids and by 20 different trainees, residents, and fellows in 54 eyelids. Six patients died (11%) within 6 months of surgery and 2 patients (3.5%) were lost to follow-up, resulting in 47 evaluable patients (54 eyelids). The follow-up period was 12 to 34 months (mean, 18 months). Fifty-three of 54 eyelids (98%)-had a successful outcome with no recurrence. The surgery was effective when performed by different grades of surgeon (P > 0.4). Conclusions: The LTS+ES is a simple operation for the correction of involutional entropion that can be performed effectively by both residents and fellows. | Barnes J.A. Bunce C. Olver J.M. 王永强 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，5： | 0 |
| 6 | 白内障手术Tenon囊下阻滞麻醉与表面麻醉的随机对照试验:患者满意度的比较研究 | Rüschen uschen H. Celaschi D. Bunce C. Carr C. H. RMoorfields 邢咏新 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，8： | 0 |
| 7 | 血管紧张素-1转化酶(ACE)基因多态性缺失和原发性开角型青光眼眼部体征的关系 | Bunce C. Hitchings R.A. Van Duijn C.M. 杜兆江 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，10： | 0 |
| 8 | 预防性激光治疗单侧年龄相关性黄斑病变促进脉络膜新生血管形成:玻璃膜疣激光研究的最终结果显示文摘PURPOSE: The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM). DESIGN: Prospective, interventional, randomized, controlled clinical trial in five hospital centers. METHODS: Patients in the unilateral group had neovascular ARM and drusen in the study eye. Study eyes were randomized to laser-treated or no-laser groups. For patients in the bilateral drusen group, eyes were randomized to right eye, laser or no laser; and left eye, alternative. Laser treatment comprised 12 argon spots. Outcome was best-corrected visual acuity and CNV signs, which were monitored for 3 years. RESULTS: In the unilateral group, vision loss occurred in 21 (28.8%) of 73 patients in laser vs 13 (19.7%) of 66 no-laser patients (P=.214). Incidence of CNV was 27 (29.7%) of 91 in laser vs 15 (17.65%) of 85 no-laser patients (P=.061). CNV onset was approximately 6 months earlier in laser-treated compared with no-laser patients (P=.05). In the bilateral group, vision loss occurred in six (8.3%)-of 72 laser-treated vs 10 (13.9%) of 72 fellow eyes (P=.3877). CNV incidence was 12 (11.6%) of 103 in laser-treated vs seven (6.8%) of 103 fellow eyes (P=.225). There was no difference in onset of CNV. CONCLUSIONS: Results do not support prophylactic laser of the fello weye of patients with neovascular ARM. Its role in patients with bilateral drusen remains unclear. | Owens S.L. Bunce C. Brannon A.J. 潘佳鸿 | 2006 | 世界核心医学期刊文摘(眼科学分册)2006，2，5： | 0 |
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