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| 1 | Saponins from Panax japonicus attenuate age-related neuroinflammation via regulation of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways显示文摘Neuroinflammation is recognized as an important pathogenic factor for aging and related cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling pathways may mediate neuroinflammation. Saponins from Panax japonicus are the most abundant and bioactive members in rhizomes of Panax japonicus, and show anti-inflammatory activity. However, it is not known whether saponin from Panax japonicus has an anti-inflammatory effect in the aging brain, and likewise its underlying mechanisms. Sprague-Dawley rats were divided into control groups(3-, 9-, 15-, and 24-month-old groups) and saponins from Panax japonicus-treated groups. Saponins from Panax japonicus-treated groups were orally administrated saponins from Panax japonicus at three doses of 10, 30, and 60 mg/kg once daily for 6 months until the rats were 24 months old. Immunohistochemical staining and western blot assay results demonstrated that many microglia were activated in 24-month-old rats compared with 3-and 9-month-old rats. Expression of interleukin-1β, tumor necrosis factor-α, cyclooxygenase-2, and inducible nitric oxide synthase increased. Each dose of saponins from Panax japonicus visibly suppressed microglial activation in the aging rat brain, and inhibited expression levels of the above factors. Each dose of saponins from Panax japonicus markedly diminished levels of nuclear factor kappa B, IκBα, extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38. These results confirm that saponins from Panax japonicus can mitigate neuroinflammation in the aging rat brain by inhibition of the mitogen-activated protein kinase and nuclear factor kappa B signaling pathways. | Li-li Deng Ding Yuan Zhi-yong Zhou Jing-zhi Wan Chang-cheng Zhang Chao-qi Liu Yao-yan Dun Hai-xia Zhao Bo Zhao Yuan-jian Yang Ting Wang | 2017 | Neural Regeneration Research2017，12，11： | 17 |
| 2 | Thermal conductivity behavior of SPS consolidated AlN/Al composites for thermal management applications显示文摘AlN/Al composites are a potentially new kind of thermal management material for electronic packaging and heat sink applications.The spark plasma sintering (SPS) technique was used for the first time to prepare the AlN/Al composites,and attention was focused on the effects of sintering parameters on the relative density,microstructure and,in particular,thermal conductivity behavior of the composites.The results showed that the relative density and thermal conductivity of the composites increased with increasing sintering temperature and pressure.The composites sintered at 1550 ℃ for 5 min under 70 MPa showed the maximum relative density and thermal conductivity,corresponding to 99% and 97.5 W m-1 K-1,respectively.However,the thermal conductivity of present AlN/Al composites is still far below the theoretical value.Possible reasons for this deviation were discussed. | DUN Bo JIA Xian JIA Chengchang CHU Ke | 2011 | Rare Metals2011，30，2： | 5 |
| 3 | Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes显示文摘 | Bo Ahrén Anja Schweizer Sylvie Dejager Beth E. Dunning Peter M. Nilsson Margaretha Persson James E. Foley | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，4： | 3 |
| 4 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 5 | Protective effect of bicyclol on lipopolysaccharide-induced acute lung injury in mice 显示文摘 | YING LUO BO ZHANG DUN QUAN XU | 2011 | Pulmonary Pharmaeology~ Therapeutics2011，24，： | 1 |
| 6 | Binding of 4-(N, N dimethylamino) pyridine to Salen-and Salan-Cr (Ⅲ) cat- ions: a mechanistic understanding on the difference in their catalytic activity for CO2/epoxide copolymerization 显示文摘 | RAO Dun Yan LI Bo ZHANG Rong | 2009 | Inorg Chem2009，48，7： | 1 |
| 7 | Solar X-ray and EUV imager on board the FY-3E satellite显示文摘The solar X-ray and Extreme Ultraviolet Imager(X-EUVI),developed by the Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences(CIOMP),is the first space-based solar X-ray and Extreme ultraviolet(EUV)imager of China loaded on the Fengyun-3E(FY-3E)satellite supported by the China Meteorological Administration(CMA)for solar observation.Since started work on July 11,2021,X-EUVI has obtained many solar images.The instrument employs an innovative dual-band design to monitor a much larger temperature range on the Sun,which covers 0.6-8.0 nm in the X-ray region with six channels and 19.5 nm in the EUV region.X-EUVI has a field of view of 42′,an angular resolution of 2.5″per pixel in the EUV band and an angular resolution of 4.1″per pixel in the X-ray band.The instrument also includes an X-ray and EUV irradiance sensor(X-EUVS)with the same bands as its imaging optics,which measures the solar irradiance and regularly calibrates the solar images.The radiometric calibration of X-EUVS on the ground has been completed,with a calibration accuracy of 12%.X-EUVI is loaded on the FY-3E satellite and rotates relative to the Sun at a uniform rate.Flat-field calibration is conducted by utilizing successive rotation solar images.The agreement between preliminarily processed X-EUVI images and SDO/AIA and Hinode/XRT images indicates that X-EUVI and the data processing algorithm operate properly and that the data from X-EUVI can be applied to the space weather forecast system of CMA and scientific investigations on solar activity. | Bo Chen Xiao-Xin Zhang Ling-Ping He Ke-Fei Song Shi-Jie Liu Guang-Xing Ding Jin-Ping Dun Jia-Wei Li Zhao-Hui Li Quan-Feng Guo Hai-Feng Wang Xiao-Dong Wang Yun-Qi Wang Hong-Ji Zhang Guang Zhang Zhen-Wei Han Shuang Dai Pei-Jie Zhang Liang Sun Yang Liu software engineer Peng Wang Kun Wu Chen Tao Shi-Lei Mao Gui Mei Liang Yang Li-Heng Chen Chun-Yang Han Bin Huang Yang Liu mechanical engineer Shuai Ren Peng Zhou Ze-XiWei Xiao-Xue Zhang Yue Zhang Xin Zheng Yang Wang Ya Chen Jing-Jiang Xie Fei He Qiao Song Wei-Guo Zong Xiu-Qing Hu Peng Zhang Jing-Song Wang Zhong-Dong Yang | 2022 | Light(Science & Applications)2022，11，12： | 0 |
| 8 | Two-weight Norm Inequalities for Local Fractional Integrals on Gaussian Measure Spaces显示文摘In this paper,the authors establish the two-weight boundedness of the local fractional maximal operators and local fractional integrals on Gaussian measure spaces associated with the local weights.More precisely,the authors first obtain the two-weight weak-type estimate for the locala fractional maximal operators of orderαfrom L^(p)(v)to L^(q,∞)(u)with 1≤p≤q<∞under a condition of(u,v)∈∪b>a A_(p,q,a)^(b') ,and then obtain the two-weight weak-type estimate for the local fractional integrals.In addition,the authors obtain the two-weight strong-type boundedness of the local fractional maximal operators under a condition of(u,v)∈M_(p,q,a)^(6a+9√da^2) and the two-weight strong-type boundedness of the local fractional integrals.These estimates are established by the radialization method and dyadic approach. | Bo Ning DI Qian Jun HE Dun Yan YAN | 2022 | Acta Mathematica Sinica,English Series2022，38，7： | 0 |
| 9 | 1.5-m flat imaging system aligned and phased in real time显示文摘Flat optics has been considered promising for constructions of spaceborne imaging systems with apertures in excess of 10 m.Despite recent advances,there are long-existing challenges to perform in-phase stitching of multiple flat optical elements.Phasing the segmented planar instrument has remained at the proof of concept.Here,we achieve autonomous system-level cophasing of a 1.5-m stitching flat device,bridging the gap between the concept and engineering implementation.To do so,we propose a flat element stitching scheme,by manipulating the point spread function,which enables our demonstration of automatically bringing seven flat segments'tip/tilt and piston errors within the tolerance.With phasing done,the 1.5-m system has become the largest phased planar instrument ever built in the world,to our knowledge.The first demonstration of phasing the large practical flat imaging system marks a significant step towards fielding a 10-m class one in space,also paving the way for ultrathin flat imaging in various remote applications. | ZONGLIANG XIE KAIYUAN YANG YANG LIU TIANRONG XU BOTAO CHEN XIAFEI MA YONG RUAN HAOTONG MA JUNFENG DU JIANG BIAN DUN LIU LIHUA WANG TAO TANG JIAWEI YUAN GE REN BO QI HU YANG | 2023 | Photonics Research2023，11，7： | 0 |
| 10 | A New Post-hoc Flat Field Measurement Method for the Solar X-Ray and Extreme Ultraviolet Imager Onboard the FengYun-3E Satellite显示文摘Extreme ultraviolet(EUV)observations are widely used in solar activity research and space weather forecasting since they can observe both the solar eruptions and the source regions of the solar wind.Flat field processing is indispensable to remove the instrumental non-uniformity of a solar EUV imager in producing high-quality scientific data from original observed data.FengYun-3E(FY-3E)is a meteorological satellite operated in a Sunsynchronous orbit,and the routine EUV imaging data from the Solar X-ray and Extreme Ultraviolet Imager(X-EUVI)onboard FY-3E has the characteristic of concentric rotation.Taking advantage of the concentric rotation,we propose a post-hoc flat field measurement method for its EUV 195A channel in this paper.This method removes the small-scale and time-varying component of coronal activities by taking the median value for each pixel along the time axis of a concentric rotation data cube,and then derives the large-scale and invariable component of the quiet coronal radiation,and finally generates a flat field image.The flat field can be generated with cadences from hundreds of minutes(one orbit)to several days.Higher flat field accuracy can be achieved by employing more data.Further analysis shows that our method is able to measure the instrumental spot-like nonuniformity possibly caused by contamination on the detector,which mostly disappears after the in-orbit selfcleaning process.It can also measure the quasi-periodic grid-like non-uniformity,possibly from the obscuration of the support mesh on the rear filter.After flat field correction,these instrumental non-uniformities from the original data are effectively removed.Moreover,the X-EUVI 195A data after dark and flat field corrections are consistent with the 193A imaging data from the Atmospheric Imaging Assembly onboard the Solar Dynamics Observatory,verifying the suitability of the method.The post-hoc method does not occupy observation time,which is advantageous for space weather operations.Our method is not only suitable for FY-3E/X-EUVI but also a candidate method for the flat field measurement of future solar EUV telescopes. | Qiao Song Xianyong Bai Bo Chen Xiuqing Hu Yajie Chen Zhenyong Hou Xiaofan Zhang Lingping He Kefei Song Peng Zhang Jing-Song Wang Xiaoxin Zhang Weiguo Zong Jinping Dun Hui Tian Yuanyong Deng | 2022 | Research in Astronomy and Astrophysics2022，22，10： | 0 |
| 11 | Ultrasound-triggered piezocatalytic composite hydrogels for promoting bacterial-infected wound healing显示文摘Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection.As such,it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness.Here,based on ultrasound-triggered piezocatalytic therapy,a multifunctional hydrogel is designed to promote bacteria-infected wound healing.Under ultrasonic vibration,the surface of barium titanate(BaTiO_(3),BT)nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species(ROS)owing to the established strong built-in electric field,endowing the hydrogel with superior antibacterial efficacy.This modality shows intriguing advantages over conventional photodynamic therapy,such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers.Moreover,the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide(THM),N-(3-aminopropyl)methacrylamide hydrochloride(APMH)and oxidized hyaluronic acid(OHA)exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing.Notably,compared with the widely reported mussel-inspired adhesive hydrogels,OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized,giving it long-term and repeatable adhesion performance.Importantly,this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria,markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues. | Dun Liu Lei Li Ben-Long Shi Bo Shi Ming-Ding Li Yong Qiu Di Zhao Qun-Dong Shen Ze-Zhang Zhu | 2023 | Bioactive Materials2023，，6： | 0 |
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