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| 1 | Agricultural Risk Factors Influence Microbial Ecology in Honghu Lake显示文摘Agricultural activities, including stock-farming, planting industry, and fish aquaculture,can affect the physicochemical and biological characters of freshwater lakes. However, the effects of pollution producing by agricultural activities on microbial ecosystem of lakes remain unclear.Hence, in this work, we selected Honghu Lake as a typical lake that is influenced by agriculture activities. We collected water and sediment samples from 18 sites, which span a wide range of areas from impacted and less-impacted areas. We performed a geospatial analysis on the composition of microbial communities associated with physicochemical properties and antibiotic pollution of samples. The co-occurrence networks of water and sediment were also built and analyzed. Our results showed that the microbial communities of impacted and less-impacted samples of water were largely driven by the concentrations of TN, TP, NO_3^--N, and NO_2^--N, while those of sediment were affected by the concentrations of Sed-OM and Sed-TN. Antibiotics have also played important roles in shaping these microbial communities: the concentrations of oxytetracycline and tetracycline clearly reflected the variance in taxonomic diversity and predicted functional diversity between impacted and less-impacted sites in water and sediment samples, respectively. Furthermore, for samples from both water and sediment, large differences of network topology structures between impacted and less-impacted were also observed. Our results provide compelling evidence that the microbial community can be used as a sentinel of eutrophication and antibiotics pollution risk associated with agricultural activity; and that proper monitoring of this environment is vital to maintain a sustainable environment in Honghu Lake. | Maozhen Han Melissa Dsouza Chunyu Zhou Hongjun Li Junqian Zhang Chaoyun Chen Qi Yao Chaofang Zhong Hao Zhou Jack A Gilbert Zhi Wang Kang Ning | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 3 |
| 2 | Alcohol moduhes alveolar macrophage tumor necrosis factor-alpha superoxide anion,and nitric oxide secrition in the rat显示文摘 | Dsouza NB | 1996 | Alcohol Clin Express1996，20，1： | 1 |
| 3 | B-type natriuretic peptide limits infarct size in rat isolated hearts via KATP channel opening显示文摘 | Dsouza SP Baxter GF | 2003 | Am J Physiol Heart Circ Physiol2003，284，5： | 1 |
| 4 | Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non - secreted forms of Mycobacterium tuberculosis Ag85A 显示文摘 | BaldwinS L Dsouza C D Orme I M | 1999 | Tuber Lung Dis1999，79，4： | 1 |
| 5 | Is treatment associated hypomania rare with duloxetine :Secondary analysis of controlled tri- als in non -- bipolar depression显示文摘 | Dunner D L DSouza D N Kajdasz D K | 2005 | J Affect Disord2005，87，： | 1 |
| 6 | Illuminating the Need for Regulation in Dark Markets:Proposed Regulation of the OTC Derivatives Market显示文摘 | Frank DSouza Nan S.Ellis Lisa M.Fairchild | | 0，，： | 1 |
| 7 | Surface and subsurface characterization of epoxy - mesoporous silica composites to clarify tribological properties显示文摘 | M C Romanes N A DSouza D Coutinho | 2008 | Wear2008，265，12： | 1 |
| 8 | The bfl-1 gene is transcriptionally upregulated by the Epstein-Barr virus LMP1, and its expression promotes the survival of a Burkitt's lymphoma cell line显示文摘 | Dsouza B Rowe M Walls D | 2000 | J Virol2000，74，14： | 1 |
| 9 | Supramolecular tandem en-zyme assays显示文摘 | Dsouza R N Hennig A Nau W M | 2012 | Chem Eur J2012，18，12： | 1 |
| 10 | Illuminating the Need for Regulation in Dark Markets:Proposed Regulation of the OTC Derivatives Market显示文摘 | Frank DSouza Nan S.Ellis Lisa M.Fairchild | | 0，，： | 1 |
| 11 | Fluoxetine -induced changes in body weight and 5 - HT1A receptor - mediated hormone secretion in rats on a tryptophan -deficient diet显示文摘 | DSouza DN Zhang Y Garcia F | 2004 | Am J Physiol Regul Integr Comp Physiol2004，286，2： | 1 |
| 12 | Nebulized magnesium sulfateversus nebulized salbutamol in acute bronchial asthma:a clinical trial显示文摘 | Mangat HS Dsouza GA Jacob MS | 1998 | Eur Respir J1998，12，： | 1 |
| 13 | Illuminating the Need for Regulation in Dark Markets:Proposed Regulation of the OTC Derivatives Market显示文摘 | Frank DSouza Nan S.Ellis Lisa M.Fairchild | | 0，，： | 1 |
| 14 | Vitamin A for treating measles in children 显示文摘 | DSouza RM D'Souza R | 2002 | Cochrane Database Syst Rev2002，，00： | 1 |
| 15 | Probiotics in prevention of antibiotic associated diarrhoea:meta-analysis显示文摘 | DSOUZA AL RAJKUMAR C COOKE J | 2002 | BJM2002，324，： | 1 |
| 16 | Stereotypy of psychogenic nonepileptic seizures: insights from video-EEG monitoring 显示文摘 | Senevirame U Reutens D DSouza W | 2010 | Epilepsia2010，51，7： | 1 |
| 17 | Is treatment - associated hypomania rare with duloxetine:secondary analysis of controlled trails in non-bipolar depression 显示文摘 | DUNNER DL DSOUZA DN KAJDASZ DK | 2005 | Affect Disord2005，87，1： | 1 |
| 18 | Immunization with 60-kD Ro peptide produces different stages of preclinical autoimmunity in a Sj(o)gren's syndrome model among multiple strains of inbred mice显示文摘 | Kurien BT Dsouza A Igoe A | 2013 | Clin Exp Immunol2013，173，： | 1 |
| 19 | A morphological study of varia- tions in the branching pattern and termination of the radial artery 显示文摘 | Gupta C Ray B Dsouza AS | 2012 | Singapore Med J2012，53，3： | 1 |
| 20 | Cellular, molecu- lar, and genetic determinants of tooth eruption显示文摘 | Wise GE Frazier- Bowers S DSouza RN | 2002 | Crit Rev O- ral Biol Med2002，13，4： | 1 |
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