|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preparation and properties of an amphiphilic derivative of succinyl-chi- tosan显示文摘 | Weiping Sui Yuanhao Wang Shuli Dong | 2008 | Colloids and Surface A- Physicochemical and En- gineering Aspects2008，316，13： | 1 |
| 2 | Phase Behavior and L-phase of a New Catanionic System Formed by Cationic Hydrocarbon and a Nionic Fluorocarb on Surfaetants显示文摘 | DONG Shuli SONG Aixin HA() Jingcheng | 2010 | Colloids and Surfaces A:Physicochemical Engineering Aspects2010，359，： | 1 |
| 3 | Phase behavior and La - phase of a new catanionic system formed by cationic hydrocarbon and anionic fluorocarbon surfactants 显示文摘 | DONG SHULI SONG AIXIN HAO JINGCHENG | 2010 | Colloids and Surfaces A: Physicochem Eng Aspects2010，359，： | 1 |
| 4 | Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase显示文摘Human 5-lipoxygenase(5-LOX)is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders.Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds,3a and 3b,exhibiting a potent inhibitory profile against 5-LOX with IC_(50) values less than 1 mmol/L in cell-based assays.Here,we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fusedring system.Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX.In particular,compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity,but also significantly decreased infarct damage in a mouse model of cerebral ischemia.Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data.In conclusion,the excellent in vitro andin vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders. | Yu Zhou Jun Liu Mingyue Zheng Shuli Zheng Chunyi Jiang Xiaomei Zhou Dong Zhang Jihui Zhao Deju Ye Mingfang Zheng Hualiang Jiang Dongxiang Liu Jian Cheng Hong Liu | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 1 |
| 5 | Preparation and properties of an amphiphilic derivative of succinyl-chitosan 显示文摘 | Sui Weiping Wang Yuanhao Dong Shuli | 2008 | Colloids and Surfaces A: Physicochem Eng Aspects2008，316，13： | 1 |
| 6 | Functions of fluorosurfactants 1: Surface activities-improved and vesicle formation of the short-tailed chain sulfonate salt mixed with a fluorosurfactant显示文摘 | Aixin Song Shuli Dong Jingcheng Hao Weimin Liu Guiying Xu Hangqing Wang | 2005 | Journal of Fluorine Chemistry2005，，9： | 1 |
| 7 | Aggregation behavior offluorocarbon and hydrocarbon cationic surfactant mixtures : A study of'HNMR and 19FNMR 显示文摘 | DONG SHULI XU GUIYING HOFFMANN H | 2008 | J Phys Chem B2008，112，： | 1 |
| 8 | Interaction between dodecyl oxypropyl β-hydroxyltrimethylammonium bromide and Xanthan:MesoDyn simulation and binding isotherm measurements显示文摘MesoDyn density functional simulation method is used to study the interactions between dodecyl oxypropyl β-hydroxyltrimethylammonium bromide (C12NBr) and Xanthan (XC). The micro dynamic process of aggregate formation and the aggregate morphology are reported. Interaction between XC and nonyphenyloxypropyl β-hydroxyltrimethylammonium bromide (C9phNBr) is compared with that between XC and C12NBr. Simulation results show that the aggregate morphology of XC/C12NBr and XC/C9phNBr is of rod-like shape with helix characteristic. The binding of C9phNBr to XC is more difficult than that of C12NBr to XC. In addition, three stages for the dynamic evolution of surfactant binding to XC are observed. The simulation results agree with binding isotherms of C9phNBr (C12NBr) to XC obtained via the potentiometric titration method, which shows a typical cooperative binding between C9phNBr (C12NBr) and XC. | LI YiMing XU GuiYing CHEN AiMin DONG ShuLi YUAN ShiLing | 2007 | Chinese Science Bulletin2007，52，19： | 0 |
| 9 | Relationship Between Magnetic Field-Induced Entropy Change and Magnetic Field显示文摘The ingots with the composition of LaFe13-xSix(1.2 | Dong Qiaoyan Zhang Hongwei Shen Juelian Sun Jirong He Shuli Shen Baogen | 2005 | Journal of Rare Earths2005，23，4： | 0 |
| 10 | Mixed invasive pulmonary Mucor and Aspergillus infection:a case report and literature review显示文摘To the Editor:Invasive pulmonary mucormycosis(IPM)is a rare but life-threatening opportunistic fungal disease with a high mortality rate of 40%to 80%.[1]Although IPM accounts for approximately 9.2%of all mucormycosis cases,it has the highest mortality rate(66.6%).A definitive diagnosis of IPM depends on the histopathological findings,regardless of culture results of the respiratory tract specimens or lung tissues. | Peikun Teng Xiudi Han Shuli Zhang Dong Wei Yi Wang Deshun Liu Xuedong Liu | 2022 | Chinese Medical Journal2022，，7： | 0 |
| 11 | Water-in-Water Emulsions,Ultralow Interfacial Tension,and Biolubrication显示文摘A water-in-water(W/W)emulsion consists of droplets formed by the spontaneous liquid-liquid separation of two immiscible aqueous phases.The inherent properties of the W/W interfaces,low or ultralowinterfacial tension(γ_(W/W)=1-1000μN/m)and a large thickness of several nanometers,beget the poor inherent stability of emulsions.Herein,we report a nanofibril emulsifier having Schiff base reactivity to generate a W/W emulsion.The W/W emulsion has superior stability(stable>6 months)because collagen nanofibrils,acting as a stabilizer of W/W emulsions,can simultaneously satisfy the requirements of sizeandoverall coverage ratio of the phase interfaces.W/Wemulsions having γ_(W/W)∼10μN/m were used as synthetic synovial fluids,showing superior lubrication performance with a coefficient of friction in the range of 0.003-0.011,which has been demonstrated to be suitable for joint lubrication.An intraarticular injection assessment further confirmed this protective effect on articular cartilage in vivo.Our study reveals the mechanism of emulsion stabilization and opens up the possibility of osteoarthritis(OA)treatment using the biolubrication effects of W/W emulsions for lubricated artificial implant surfaces. | Yitong Wang Jin Yuan Yunpeng Zhao Ling Wang Luxuan Guo Lei Feng Jiwei Cui Shuli Dong Shanhong Wan Weimin Liu Heinz Hoffmann Kiet Tieu Jingcheng Hao | 2022 | CCS Chemistry2022，4，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员