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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | Neutrophil gela- tinase-associated Iipocalin(NGAL) as a marker of kidney damage显示文摘 | olignano D Donato V Coppolino G | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 3 | Combined peri- neal and endorectal repair of rectocele by circular stapler显示文摘 | Donato F Altomare MR Antonella V | 2002 | Dis Colon Rectum2002，，45： | 1 |
| 4 | Neutrophil gelatinase- associated lipocalin (NGAL) as a marker of kidney damage显示文摘 | Bolignano D Donato V Copp01ino G | 2011 | Am J Kidney Dis2011，52，3： | 1 |
| 5 | Quality of life and sexual function after type c2/type Ⅲ radical hysterectomy for locally advanced cervical cancer: a prospective study 显示文摘 | Plotti F Sensone M Di Donato V | 2011 | J Sexual Medicine2011，8，3： | 1 |
| 6 | Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage 显示文摘 | Bolignano D Donato V Coppolino G | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 7 | Human Hepatocytes in primary culture:the choice to investigate drug metabolism in man显示文摘 | GOMEZ-LECHON M J DONATO M T CASTELL J V | 2004 | Current Drug Metabolism2004，5，5： | 1 |
| 8 | Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage 显示文摘 | Bolignano D Donato V Coppolino G | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 9 | Treatment pat- terns in patients with advanced breast cancer who were exposed to an anthracycline, a taxane, and eapecit- abine: a descriptive report 显示文摘 | Donato B M Burns L Willey V | 2010 | Clinical Therapeutics2010，32，3： | 1 |
| 10 | Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism显示文摘 | Donato M T Castell J V | 2003 | Clin Pharmacokinet2003，42，： | 1 |
| 11 | CO21aser treatment for Bartholin gland abscess: ultrasound evaluation of risk recurrence 显示文摘 | Di Donato V Bellati F Casorelli A | 2013 | J Minim Invasive Gynecol2013，20，3： | 1 |
| 12 | Vaginal cancer 显示文摘 | Di Donato V Bellati F Fischetti M | 2011 | Crit Rev Oncol Hematol2011，13，： | 1 |
| 13 | Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage显示文摘 | Bolignano D Donato V Coppolino G | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 14 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 15 | Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a marker of kidney damage显示文摘 | BOLIGNANO D DONATO V COPPPLINO G | 2008 | Am J Kidney Dis2008，52，： | 1 |
| 16 | Politcal and monetary institutions and public finance policies in the industrial counutries显示文摘 | Grilli V Donato M A Guido T A | 1991 | Economic Policy1991，，13： | 1 |
| 17 | Neutro- phil gelatinase- associated lipocalin (NGAL) as a marker of kidney damage显示文摘 | Bolignano D Donato V Coppolino G | 2008 | Am J Kidney Dis2008，52，3： | 1 |
| 18 | Observing the quantum behavior of light in an undergraduate laboratory显示文摘 | THORN J J NEAL M S DONATO V W | 2004 | Am J Phys2004，72，： | 1 |
| 19 | Ischemic postconditioning reduces infarct size by activation of A1 receptors and KATP channels in both normal and hypercholesterolemic rabbits显示文摘 | Donato M D'Annunzio V Berg G | 2007 | J Cardiovasc Pharmacol2007，49，： | 1 |
| 20 | Radiontherapy alone in elderly patients with medically inoperable stage ]IIA and IIB non- small cell lung cancer显示文摘 | Tombolini V Bonanni A Donato V | 2000 | Anticancer Res2000，20，60： | 1 |
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