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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 血管紧张素Ⅱ2型受体的基因多态性(+1675G/A)对已接受治疗高血压患者的左心室肥大和左心室构型的作用显示文摘已有报道显示血管紧张素Ⅱ2型受体的基因多态性(AGTR2+1675G/A)与左心室肥大(left ventric-ular hypertrophy,LVH)相关。研究者检验这种基因多态性是否影响已按高血压治疗指南治疗的原发性高血压和心血管疾病患者的LVH和左心室构型参数。 | 张玲玉 叶鹏 Huber M V ller H Jakob S Reibis R Do V Bol-brinker J Zergibel I Schmieder RE Treszl A Wegscheider K Kreutz R | 2010 | 中华高血压杂志2010，18，12： | 6 |
| 3 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 4 | Comparison between in vivo dosimetry and barium contrast technique for prediction of rectal complications in high - dose - rate intracavitary radiotherapy in cervix cancer patients 显示文摘 | Huh S J Lim do H Ahn YC | 2003 | Strahlenther Onkol2003，179，3： | 1 |
| 5 | Microsomal prosta- glandin E synthase is regulated by proinflammatory crtokines and glucocorticoids in primary rheumatoid synovial cells显示文摘 | Stichtenoth DO Thoren S Bian H | 2001 | J Immu- nol2001，167，1： | 1 |
| 6 | Slump loss control of cement paste by adding polycarboxylic type slump-releasing dispersant 显示文摘 | GYE G SEONG S H DO S K | 1999 | Cem Concr Res1999，29，2： | 1 |
| 7 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 8 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 9 | The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells(hMSCs)and in-duce chondrogenesis显示文摘 | Kim J H Park J S Yang H N Woo D G Jeon S Y Do H J | 2011 | Biomaterials2011，32，： | 1 |
| 10 | Analytical and experimental investigation on the operational characteristics and the thermal optimization of a miniature heat pipe with a grooved wick structure 显示文摘 | Kim S J Seo J K Do K H | 2003 | International Journal of Heat and Mass Transfer2003，46，11： | 1 |
| 11 | Postoperative spinal epidural hematoma:risk factor and clinical outcome显示文摘 | Yi S Yoon do H Kim K N | 2006 | Yonsei Med J2006，47，3： | 1 |
| 12 | Application of Design Axioms for Glass Bulb Design and Software Development for Design Automatiom显示文摘 | Do S H Park G J | 2001 | Journal of Mechanical Design2001，123，： | 1 |
| 13 | Structural effects of n-aromatic acyl-aminoacid conjugates on their deconjugation in the cecal contentsof rats: implication in design of a colon-specific prodrugwith controlled conversion rate at the target site 显示文摘 | Kong H Kim H Do H Lee Y Hong S Yoon J H JungY Kim Y M | 2011 | Bio pharmaceutics Drug Disposition2011，32，6： | 1 |
| 14 | The Effects of Time Constraints on Test Case Prioritization:A Series of Controlled Experiments显示文摘 | Do H Mirarab S Tahvildari L | 2010 | IEEE Transactions on Software Engineering2010，36，5： | 1 |
| 15 | Molybdenum oxide anode buffer layers for solution processed,blue phosphorescent small molecule organic light emitting diodes显示文摘 | H?fle S Do H Mankel E | 2013 | Organic Electronics2013，14，7： | 1 |
| 16 | Phase Ⅲ trial comparing capecitabine plus cisplatin versus capecitabine plus cisplatin with concurrent capecitabine radiotherapy in completely resected gastric cancer with D2 lymph node dissection: the ARTIST trial显示文摘 | Lee J Lira do H Kim S | 2012 | J Clin Oncol2012，30，3： | 1 |
| 17 | Electrochemical properties of nano-sized Li4Ti5O12 powders synthesized by a sol-gel process and characterized by X-ray absorption spectroscopy显示文摘 | VENKATESWARLU M CHEN C H DO J S | 2005 | J Power Sources2005，146，12： | 1 |
| 18 | Neurotoxicity induced by glutamate in glucose-deprived rat hippocampal slices is prevented by GMP显示文摘 | Molz S Decker H Oliveira IJ Souza DO Tasca CI | 2005 | Neurochem Res2005，30，1： | 1 |
| 19 | Differential expression and in situ localization of a pepper defensin (CADEF1) gene in response to pathogen infection, abiotic elicitors and environmental stresses in Capsicum annuum 显示文摘 | Do H M Lee S C Jung H W | 2004 | Plant Sci2004，166，： | 1 |
| 20 | Validation of foot and ankle out- come score for hallux valgus 显示文摘 | Chen L Lyman S Do H | 2012 | Foot Ankle Int2012，33，12： | 1 |
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