|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 2 | Diabetes mellitus:An overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity显示文摘Diabetes mellitus is not a single disease but is a group of metabolic disorders affecting a huge numlier of population in the world.It is mainly characterized by chronic hyperglycemia,resulting from defects in insulin secretion or insulin action.It is predicated that the number of diabetes person in the world could reach upto 366 million by the year 2030.Even though the cases of diabetes are increasing day by day,except insulin and oral hypoglycemic drugs no other way of treatment has been successfully developed so far.Thus,the objective of the present review is to provide an insight over the pathophysiological and etiological aspects of diabetes mellitus along with the remedies available for this metabolic disorder.The review also contains brief idea about diabetes mellitus and the experimental screening model with their relevant mechanism and significance mainly used nowadays.Alloxan and streptozotocin are mainly used for evaluating the antidiabetic activity of a particular drug.This review contain list of medicinal plants which have been tested for their antidiabetic activity in the alloxan induced diabetic rat model.From the available data in the literature,it was found that plant having antidiabetic activity is mainly due to the presence of the secondary metabolite.Thus,the information provided in this review will help the researchers for the development of an alternative methods rather than insidin and oral hypoglycemic agents for the treatment of diabetes niellitus,which will minimize the complication associated with the diabetes and related disorder. | Patel DK Kumar R Laloo D Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，5： | 17 |
| 3 | An overview on antidiabetic medicinal plants having insulin mimetic property显示文摘Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year 2025.Since long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech medicine.In view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics activity.From the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and Araliaceae.The most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts bengalensis.The review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents.Thus,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose levels.The review also discusses the management aspect of diabetes mellitus using these plants and their active principles. | Patel DK Prasad SK Kumar R Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 4 | Pedalium murex Linn(Pedaliaceae) fruits:a comparative antioxidant activity of its different fractions显示文摘Objective:To examine the antioxidant activity and total phenolic content of different solvent fractions of Pedulium murex(P.murex)Linn fruits(Family:Pedaliaceae)as well as the correlation between the total antioxidant capacity and total phenolic content.Methods:In the present study,the antioxidant activities of P.murex were evaluated using six in-vitro assays,namely total antioxidant assay,DPPH assay,reducing power,nitric oxide scavenging,hydrogen peroxide scavenging and deoxyribose scavenging assays,and total phenol contents were also investigated.Results:The ethyl acetate(EA)fraction was found to have high levels of phenolic content(298.72±2.09 mg GAE/g).The EA fraction exhibit higher total antioxidant capacity,higher percentage of DPPH radical scavenging activity(135.11±2.95μg/mL),nitric oxide(200.57±4.5lμg/mL),hydrogen peroxide(2I7.91±6.12μg/mL),deoxyribose(250.01±4.68μg/mL)and higher reducing power.Correlation coefficient(r^2=0.914)was found to be significant between total phenolic content and total antioxidant activity.Conclusions:In general,the results indicate that the EA fractions are rich in phenolic antioxidants with potent free radical scavenging activity implying their importance to human health. | DK Patel R Kumar SK Prasad S Hemalatha | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，5： | 12 |
| 5 | Barbaloin:A concise report of its pharmacological and analytical aspects显示文摘Barbaloin is C-glucoside of aloe emodin unthrone which is found in the plant name as Aloe vera is a perennial succulenl(Liliaceal),also called the healing planl.Barbaloin have variety of pharmacological activity such as strong inhibitory effect on histamine release,anti-inflammatory,cathartic,antiviral,antimicrobial,anticancer,antioxidant activity and alternative for pharmaceutical or cosmetic applications.The peak amount of barbaloin was reached about 3 h after oral administration.Concentration of barbaloin in Aloe vera leaves was shown to depend on the leaf part,age,and position of the leaf.Young leaves contain more barbaloin compared to old one.Various researches have been done on barbaloin but still the relationship between the barbaloin and its overall effect has not been clarified.A more specific;perceptive of the pharmacological activities of barbaloin is required to develop for pharmaceutical purpose.Many attempts have been made regarding its isolation,biological activity to examine their effects,and clarify their functional mechanism.This review gives a brief idea about its uses,ethnomedicinally and commercially important analytical techniques and their pharmacological activities. | DK Patel K Patel V Tahilyani | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，10： | 5 |
| 6 | Evaluation of in vitro aldose reductase inhibitory potential of different fraction of Hybanthus enneaspermus Linn F.Muell显示文摘Objective:To evaluate the aldose reductase inhibitory(ARI)activity of different fractions of Hybanthus enneaspermus for potential use in diabetic cataract.Methods:Total phenol and flavonoid content of different fractions was determined.ARI activity of different fractions in rat lens was investigated in vitro.Results:The results showed significant level of phenolic and flavonoid content in ethyl acetate fraction[total phenol(212.15±0.79 mg/g),total flavonoid(39.11±2.27mg/g)]and aqueous fraction[total phenol(140.62±0.57mg/g),total flavonoid(26.07±1.49 mg/g)]as compared with the chloroform fraction[total phenol(68.56±0.51mg/g),total flavonoid(13.41±0.82mg/g)]and petrolium ether fraction[total phenol(36.68±0.43mg/g),total flavonoid(11.55±1.06mg/g)].There was a significant difference in the ARI activity of each fraction,and it was found to be the highest in ethyl acetate fraction[IC_(50)(49.26±1.76μg/mL)]followed by aqueous extract[IC_(50)(70.83±2.82μg/mL)]and it was least in the petroleum ether fraction[IC_(50)(118.89±0.71μg/mL)].Chloroform fraction showed moderate activity[IC_(50)(98.52±1.80μg/mL)].Conclusions:Different fractions showed significanct amount of ARI activity,where in ethyl acetate fraction it was found to be maximum which may be due to its high phenolic and flavonoid content.The extract after further evaluation may be used in the treatment of diabetic cataract. | Patel DK Kumar R Kumar M Sairarn K Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 4 |
| 7 | Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects显示文摘 | DK Patel R Kumar D Laloo S Hemalatha | 2012 | Asian Pacific Journal of Tropical Disease2012，，3： | 2 |
| 8 | Cataract: A major secondary complication of diabetes, its epidemiology and an overview on major medicinal plants screened for anticataract activity显示文摘 | DK Patel SK Prasad R Kumar S Hemalatha | 2011 | Asian Pacific Journal of Tropical Disease2011，，4： | 2 |
| 9 | Blood levels of polycyclic aromatic hydrocarbons in children and their association with oxidative stress indices: an Indian perspective显示文摘 | Singh VK Patel DK Jyoti | 2008 | Clin Biochem2008，41，3： | 1 |
| 10 | Outcome of local bone versus autogenous iliac crest bone graft in the instrumen- ted posterolateral fusion of the lumbar spine显示文摘 | Sengupta DK Truumees E Patel CK | 2006 | Spine2006，31，9： | 1 |
| 11 | A review of complications asso- ciated with craniocervieal fusion surgery 显示文摘 | Lall R Patel NJ Resnlck DK et a/ | 2010 | Neurosurgery2010，67，5： | 1 |
| 12 | Blood levels of polycyclic aromatic hydrocarbons in children and their association with oxidative stress indices:an Indian perspective显示文摘 | Patel DK Jyoti | 2008 | Clin Biochem2008，41，3： | 1 |
| 13 | A review of complications associat- ed with craniocervical fusion surgery 显示文摘 | Lall R Patel NJ Resnick DK | 2010 | Neurosurgery2010，67，5： | 1 |
| 14 | Specialist neurocritical care and outcome from head injury显示文摘 | Patel HC Menon DK Tebbs S | 2002 | Intensive Care Med2002，28，5： | 1 |
| 15 | Lichens reveal air PAH fractionation in the Himalaya 显示文摘 | Shukla V Upreti DK Patel DK | 2013 | Environ Chem Lett2013，11，1： | 1 |
| 16 | Bloodstream infections with vancomycin-resistant enterococci显示文摘 | Montecalvo MA Shay DK Patel P | 1996 | Arch Intern Med1996，156，： | 1 |
| 17 | An adult with 49, XYYYY karyotype:case report and endocrine studies显示文摘 | Shanske A Sachmechi I Patel DK | 1998 | Am J Med Genet1998，80，2： | 1 |
| 18 | Innate and adap- tive immunity at mucosal surfaces of the female reproduc- tive tract:stratification and integration of immune protec- tion against the transmission of sexually transmitted infec- tions 显示文摘 | Hickey DK Patel MV Fahey JV | 2011 | J Reprod Immunol2011，88，2： | 1 |
| 19 | A review of complications associated with craniocervical fusion surgery 显示文摘 | Lall R Patel NJ Resnick DK | 2010 | Neurosurgery2010，67，5： | 1 |
| 20 | Prevalence and treatment of cephalic arch stenosis in dysfunctional autogenous hemodialysis ?stulas显示文摘 | Rajan DK Clark TW Patel NK | 2003 | J Vasc Interv Radiol2003，14，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员