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		题名	作者	年代	出处	被引量
	1	A host parasite interaction rescues Drosophila oogenesis defects显示文摘	Stair DJ Cline TW	2002	Nature2002，418，6893：	1
	2	Neurobehavioral effects of environmental enrich- ment and drug abuse vulnerability 显示文摘	Stairs DJ Bardo MT	2009	Pharmacol Biochem Behav2009，92，3：	1
	3	Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory显示文摘	Hillman BG Gupta SC Stairs DJ	2011	Neurobiol Learn Mem2011，95，4：	1
	4	Effects of environmental enrichment on extinction and reinstatement of amphetamine self-administration and sucrose-maintained responding显示文摘	Stairs DJ Klein ED Bardo MT	2006	Behav Pharmacol2006，17，7：	1
	5	Effect of differential rearing environments on nicotine-stimulated locomotor activity and nicotinic acetylcholine receptor subtypes显示文摘OBJECTIVE Individuals vary in sensitivity to the behavioral effects of nicotine,resulting in differences in their vulnerability to addiction.The role of rearing environment in determining individual sensitivity to nicotine is unclear.The neuropharmacological mechanisms mediating the effect of rearing environment on the actions of nicotine are also understood.Thus,the contribution of rearing environment in determining the sensitivity to the locomotor effects of nicotine and regulating α4β2-and α7-nicotinic acetylcholine(n ACh) receptor expressionwas determined in rats reared in isolated(IC) or enriched(EC) conditions.METHODS To measure locomotor activity,adolescent rats(postnatal day 21-51)were injected with saline(1 mL·kg^(-1)) or nicotine(0.3 mg·kg^(-1)) subcutaneously,then placed in chamberswhere ambulatory activity was monitored for 30-min by computer for 14 daily sessions.α4β2-andα7-n ACh receptor expression in the mesolimbic dopamine pathway was determined by quantitative autoradiography of [125 I]-epibatidine and [125 I]-bungarotoxinbinding,respectively,in 16 μmol·L^(-1) coronal sections.Values for receptor expression in fmol are ±s of 8 brains and compared by two-tailed,unpaired t-test with P<0.05 considered significant.RESULTS EC-rats are similarly sensitive as IC-rats to the locomotor effects of nicotine.[125 I]-epibatidine binding in the ventral tegmental area of EC-rats was reduced(2.8±0.3 fmo L) compared to IC-rats(4.0±0.4 fmo L);there was no difference in the nucleus accumbens.There was no difference between EC-and IC-rats in α7-n ACh receptor expression in the mesolimbic dopamine pathway.CONCLUSION Rearing environment differentially regulates n ACh receptor subtypes in EC and IC rats.These data suggest regulation of n ACh receptors by environmental factors may be a mechanism for the protective effect of enrichment against altered sensitivity to nicotine in genetically vulnerable individuals.The characterization of these mechanisms will aid in development of novel pharmacological tools mimicking the protection afforded by environmental enrichment in nicotine-sensitive individuals.	CS BOCKMAN M QUAST DJ STAIRS	2017	中国药理学与毒理学杂志2017，31，10：	0

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