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| 1 | Psychotropic drugs and liver disease:A critical review of pharmacokinetics and liver toxicity显示文摘The liver is the organ by which the majority of sub-stances are metabolized, including psychotropic drugs. There are several pharmacokinetic changes in end-stage liver disease that can interfere with the metabolization of psychotropic drugs. This fact is particularly true in drugs with extensive first--pass metabolism, highly protein bound drugs and drugs depending on phase I hepatic metabolic reactions. Psychopharmacological agents are also associated with a risk of hepatotoxicity. The evidence is insufficient for definite conclusions regarding the prevalence and severity of psychiatric drug-induced liver injury. High-risk psychotropics are not advised when there is pre-existing liver disease, and after starting a psychotropic agent in a patient with hepatic impairment, frequent liver function/lesion monitoring is advised. The authors carefully review the pharmacokinetic disturbances induced by end-stage liver disease and the potential of psychopharmacological agents for liver toxicity. | Diogo Telles-Correia António Barbosa Helena Cortez-Pinto Carlos Campos Nuno B F Rocha Sérgio Machado | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 3 |
| 2 | The corpus cavernosum after treatment with dutasteride or finasteride: a histomorphometric study in a benign prostatic hyperplasia rodent model显示文摘 | Marcello H A Da Silva Waldemar S Costa Francisco J B Sampaio Diogo B De Souza | 2018 | Asian Journal of Andrology2018，20，5： | 2 |
| 3 | Immediate and late effects of chronic stress in the testes of prepubertal and adult rats显示文摘这研究的目的是在 prepubertal 和成年老鼠的睾丸上调查长期的应力的效果并且评估任何改变是否能被颠倒什么时候强调正式就职被结束。老鼠被分到八的 76 男性组织取决于处理的类型(控制或强调) ,应力在被开始的年龄(prepubertal 或成年人) ,和评估的时间(立即或迟了) 。压力刺激 6 个星期被申请。在最后压力刺激以后立即评估的强调 prepubertal 和成年老鼠分别地在 SP-I 和 SA-I 组被包括。迟了的 prepubertal (系统程序设计语言) 和成年人(柳安) 强调老鼠组织 6 个星期在最后压力刺激以后被评估。匹配年龄的老鼠被用作控制(CP-I, CA-I, CP-L,和 CA-L 组) 。到在 SP-I 组的老鼠的压力刺激的申请导致了身体重量和生精的小管直径减小。在 SA-I 组的老鼠也显示出几功能(睾丸激素水平和精子参数) 并且词法(阴囊的重量和生精的小管直径) 减小。在系统程序设计语言组的老鼠显示出增加的身体重量和 intertubular 分隔空间容量、绝对的密度和减少的管状的分隔空间容量的密度。在柳安组的老鼠介绍了仅仅减少的精子生存能力。压力刺激在所有学习组在老鼠支持了变化。成年老鼠的睾丸是长期的应力影响的大多数。然而,强调成年老鼠从阴囊的改变恢复了很好。 | Carina T Ribeiro Diogo B De Souza Waldemar S Costa Francisco J B Sampaio Marco A Pereira-Sampaio | 2018 | Asian Journal of Andrology2018，20，4： | 2 |
| 4 | Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity显示文摘 | Han B Diogo D Eyre S | 2014 | Am J Hum Genet2014，94，： | 1 |
| 5 | Time-dependent healthrisk from contaminated groundwater including use of reliability, re-silience, and vulnerability as measures 显示文摘 | CAROLYN Rf SILLIMAN S E DIOGO B | 2013 | Journal of the AmericanWater Resources Association ( JAWRA )2013，50，1： | 1 |
| 6 | Multi-genera- tion studies with Chironomus riparius-Effcets of low tributyltin concentrations on life history parameters and genetic diversity 显示文摘 | Vogt C Nowak C Diogo J B | 2007 | Chemosphere2007，67，： | 1 |
| 7 | Advances in ethanol production from hardwood spent sulphite liquors 显示文摘 | Susana R Pereira Diogo J Portugal-Nunes Dmitry V Evtuguin Luísa S Serafim Ana M R B Xavier | 2013 | Process Biochemistry2013，48，2： | 1 |
| 8 | Review:auto-oxidation of aliphatic polyamides显示文摘 | E Richaud O O Diogo B Fayolle | 2013 | Polymer Degradation and Stability2013，98，9： | 1 |
| 9 | Theoretical insights into the mechanism of action of atypical antipsychotics 显示文摘 | Adriano B L Tort Diogo O | 2006 | Progress in Neuro-Psychopharmacology ~ Biological Psychiatry2006，，30： | 1 |
| 10 | Multigeneration studies with Chironomus riparius-effects of low tributyhin concentrations on life history parameters and genetic diversity 显示文摘 | VOGT C NOWAK C DIOGO J B | 2007 | Chemosphere2007，67，： | 1 |
| 11 | Sound transmission through single,double and triple glazing 显示文摘 | Antonio J B Tadeu Diogo M R Mateus | 2001 | Applied Acoustics2001，，62： | 1 |
| 12 | Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities显示文摘BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer detection.Endoscopic ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion characterization.While no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic diseases.AIM To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by EUS.METHODS This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,Portugal.All patients provided written informed consent.EUS and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all subjects.EUS-guided tissue acquisition was done whenever necessary.For statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was used.All graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(82.0%,IQR:28.9%-98.2%),NLOD(12.6%,IQR:5.2%-63.4%),and CG(16.2%,IQR:6.6%-20.1%)(P<0.0001).Median levels of CA 19-9 were within the normal range in all groups(standard clinical cut-off of 37 U/mL).Within HR,individuals with a positive history of cancer had higher median levels of GPC1+crExos(97.9%;IQR:61.7%-99.5%),compared to those without(59.7%;IQR:26.3%-96.4%),despite no statistical significance(P=0.21).Pancreatic cysts with WF/HRS were statistically associated with higher median levels of GPC1+crExos(99.6%;IQR:97.6%-99.8%)compared to those without(96.5%;IQR:81.3%-99.5%)(P=0.011),presenting an area under the receiver operating characteristic curve value of 0.723(sensitivity 75.0%and specificity 67.7%,using a cutoff of 98.5%;P=0.012).CONCLUSION GPC1+crExos may act as biomarker to support the diagnosis and stratification of PDAC precursor lesions,and in signaling individuals with genetic predisposition in the absence of EUS abnormalities. | Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva Rui Morais Armando Peixoto Rosa Coelho Pedro Costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo | 2022 | World Journal of Gastroenterology2022，28，31： | 0 |
| 13 | Maternal low protein diet induces persistent expression changes in metabolic genes in male rats显示文摘BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and humans.Numerous adaptive responses to maternal protein restriction have been reported in metabolic tissues.However,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be described.AIM To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose tissue.METHODS In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and lactation.We also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic genes.RESULTS In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene expression.Such transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 d.These gene alterations,together with previously described changes in gene expression in skeletal muscle,may account for the metabolic adaptations in response to maternal LP diet and highlight the occurrence of persistent transcriptional defects in key metabolic genes that may contribute to the development of metabolic alterations during the adult life as a consequence of perinatal malnutrition.CONCLUSION We conclude that perinatal malnutrition relays long-lasting transcriptional alterations in metabolically active organs,i.e.,liver and adipose tissue. | Allan de Oliveira Lira JoséLuiz de Brito Alves Mariana Pinheiro Fernandes Diogo Vasconcelos David Filipe Santana João Henrique da Costa-Silva Béatrice Morio Carol Góis Leandro Luciano Pirola | 2020 | World Journal of Diabetes2020，11，5： | 0 |
| 14 | Fungal diversity notes 1277-1386:taxonomic and phylogenetic contributions to fungal taxa显示文摘This is the twelfth contribution to the Fungal Diversity Notes series on fungal taxonomy,based on materials collected from many countries which were examined and described using the methods of morphology,anatomy,and strain culture,combined with DNA sequence analyses.110 taxa are described and illustrated,including five new genera,92 new species,eight new combinations and other taxonomic contributions(one new sequenced species,one new host and three new records)which are accommodated in 40 families and 1 incertae sedis in Dothideomycetes.The new genera are Amyloceraceomyces,Catenuliconidia,Hansenopezia,Ionopezia and Magnopulchromyces.The new species are Amyloceraceomyces angustisporus,Amylocorticium ellipsosporum,Arthrinium sorghi,Catenuliconidia uniseptata,Clavulina sphaeropedunculata,Colletotrichum parthenocissicola,Coniothyrium triseptatum,Cortinarius indorusseus,C.paurigarhwalensis,C.sinensis,C.subsanguineus,C.xiaojinensis,Diaporthe pimpinel-lae,Dictyosporella guizhouensis,Diplodia torilicola,Fuscoporia marquesiana,F.semiarida,Hansenopezia decora,Helicoarcta-tus thailandicus,Hirsutella hongheensis,Humidicutis brunneovinacea,Lentaria gossypina,L.variabilis,Lycoperdon lahorense,L.pseudocurtisii,Magnopulchromyces scorpiophorus,Moelleriella gracilispora,Neodevriesia manglicola,Neodidymelliopsis salvia,N.urticae,Neoroussoella magnoliae,Neottiella gigaspora,Ophiosphaerella chiangraiensis,Phaeotremella yunnanensis,Podosphaera yulii,Rigidoporus juniperinus,Rhodofomitopsis pseudofeei,Russula benghalensis,Scleroramularia vermispora,Scytinopogon minisporus,Sporormurispora paulsenii,Thaxteriellopsis obliqus,Tomentella asiae-orientalis,T.atrobadia,T.atrocastanea,T.aureomarginata,T.brevis,T.brunneoflava,T.brunneogrisea,T.capitatocystidiata,T.changbaiensis,T.citri-nocystidiata,T.coffeae,T.conclusa,T.cystidiata,T.dimidiata,T.duplexa,T.efibulata,T.efibulis,T.farinosa,T.flavidobadia,T.fuscocrustosa,T.fuscofarinosa,T.fuscogranulosa,T.fuscopelliculosa,T.globospora,T.gloeocystidiata,T.griseocastanea,T.griseofusca,T.griseomarginata,T.inconspicua,T.incrustata,T.interrupta,T.liaoningensis,T.longiaculeifera,T.longiechinuli,T.megaspora,T.olivacea,T.olivaceobrunnea,T.pallidobrunnea,T.pallidomarginata,T.parvispora,T.pertenuis,T.qingyuanensis,T.segregata,T.separata,T.stipitata,T.storea,Trichoderma ceratophylletum,Tyromyces minutulus,Umbelopsis heterosporus and Xylolentia reniformis.The new combinations are Antrodiella descendena,Chloridium macrocladum,Hansenopezia retrocurvata,Rhodofomitopsis monomitica,Rh.oleracea,Fuscoporia licnoides,F.scruposa and Ionopezia gerardii.A new sequenced species(Graphis supracola),one new host(Aplosporella prunicola)and three new geographical records(Golovinomyces monardae,Paradictyoarthrinium diffractum and Prosthemium betulinum),are reported. | Hai-Sheng Yuan Xu Lu Yu-Cheng Dai Kevin D.Hyde Yu-He Kan Ivana Kušan Shuang-Hui He Ning-Guo Liu V.Venkateswara Sarma Chang-Lin Zhao Bao-Kai Cui Nousheen Yousaf Guangyu Sun Shu-Yan Liu Fang Wu Chuan-Gen Lin Monika C.Dayarathne Tatiana Baptista Gibertoni Lucas B.Conceição Roberto Garibay-Orijel Margarita Villegas-Ríos Rodolfo Salas-Lizana Tie-Zheng Wei Jun-Zhi Qiu Ze-Fen Yu Rungtiwa Phookamsak Ming Zeng Soumitra Paloi Dan-Feng Bao Pranami DAbeywickrama De-Ping Wei Jing Yang Ishara S.Manawasinghe Dulanjalee Harishchandra Rashika S.Brahmanage Nimali Ide Silva Danushka S.Tennakoon Anuruddha Karunarathna Yusufjon Gafforov Dhandevi Pem Sheng-Nan Zhang AndréL.C.Mde Azevedo Santiago Jadson Diogo Pereira Bezerra Bálint Dima Krishnendu Acharya Julieta Alvarez-Manjarrez Ali H.Bahkali Vinod K.Bhatt Tor Erik Brandrud Timur S.Bulgakov E.Camporesi Ting Cao Yu-Xi Chen Yuan-Yuan Chen Bandarupalli Devadatha Abdallah M.Elgorban Long-Fei Fan Xing Du Liu Gao Camila Melo Gonçalves Luis F.P.Gusmão Naruemon Huanraluek Margita Jadan Ruvishika S.Jayawardena Abdul Nasir Khalid Ewald Langer Diogo X.Lima Nelson Correia de Lima-Júnior Carla Rejane Sousa de Lira Jian-Kui(Jack)Liu Shun Liu Saisamorn Lumyong Zong-Long Luo Neven Matočec M.Niranjan JoséRibamar Costa Oliveira-Filho Viktor Papp Eduardo Pérez-Pazos Alan J.L.Phillips Peng-Lei Qiu Yihua Ren Rafael F.Castañeda Ruiz Kamal C.Semwal Karl Soop Carlos A.Fde Souza Cristina Maria Souza-Motta Li-Hua Sun Meng-Le Xie Yi-Jian Yao Qi Zhao Li-Wei Zhou | 2020 | Fungal Diversity2020，，5： | 0 |
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