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| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Molecular phylogenetic relationships of China Seas groupers based on cytochrome b gene fragment sequences显示文摘The classification and evolutionary relationships are important issues in the study of the groupers. Cytochrome b gene fragment of twenty-eight grouper species within six genera of subfamily Epinephelinae was amplified using PCR techniques and the sequences were analyzed to derive the phylogenetic relationships of the groupers from the China Seas. Genetic information indexes, including Kimura-2 parameter genetic distance and Ts/Tv ratios, were generated by using a variety of biology softwares. With Niphon spinosus, Pagrus major and Pagrus auriga as the designated outgroups, phylogenetic trees, which invoke additional homologous sequences of other Epinephelus fishes from GenBank, were constructed based on the neighbor-joining (NJ), maximum-parsimony (MP), maximum-likelihood (ML) and minimum-evolution (ME) methods. Several conclusions were drawn from the DNA sequences analysis: (1) genus Plectropomus, which was early diverged, is the most primitive group in the subfamily Epinephelinae; (2) genus Variola is more closely related to genus Cephalopolis than the other four genera; (3) genus Cephalopolis is a monophyletic group and more primitive than genus Epinephelus; (4) Promicrops lanceolatus and Cromileptes altivelis should be included in genus Epinephelus; (5) there exist two sister groups in genus Epinephelus. | DING Shaoxiong, ZHUANG Xuan, GUO Feng, WANG Jun, SU Yongquan, ZHANG Qiyong & LI Qifu Department of Oceanography and Institute of Subtropical Oceanography, Xiamen University, Xiamen 361005, China Department of Biology, Xiamen University, Xiamen 361005, China | 2006 | Science China(Life Sciences)2006，49，3： | 14 |
| 3 | Endogenous Hydrogen Peroxide Plays a Positive Role in the Upregulation of Heme Oxygenase and Acclimation to Oxidative Stress in Wheat Seedling Leaves显示文摘Pretreatment of lower H2O2 doses (0.05, 0.5 and 5 mM) for 24 h was able to dose-dependently attenuate lipid peroxidation in wheat seedling leaves mediated by further oxidative damage elicited by higher dose of H2O2 (150 mM) for 6 h, with 0.5 mM H2O2 being the most effective concentrations. Further results illustrated that 0.5 mM H2O2 pretreatment triggered the biphasic production of H2O2 during a 24 h period. We also noticed that only peak I (0.25 h) rather than peak Ⅱ (4 h) was approximately consistent with the enhancement of heme oxygenase (HO) activity, HO-1 gene expression. Meanwhile, enhanced superoxide dismutase (SOD) activity, Mn-SOD and Cu,Zn-SOD transcripts might be a potential source of peak I of endogenous H2O2. Further results confirmed that 0.5 mM H2O2 treatment for 0.5 h was able to upregulate HO gene expression, which was detected by enzyme activity determination, semi-quantitative reverse transcription-polymerase chain reaction and western blotting. Meanwhile, the application of N,N'-dimethylthiourea, a trap for endogenous H2O2, not only blocked the upregulation of HO, but also reversed the corresponding oxidation attenuation. Together, the above results suggest that endogenous H2O2 production (peak I) plays a positive role in the induction of HO by enhancing its mRNA level and protein expression, thus leading to the acclimation to oxidative stress. | Xiao-Yue Chen Xiao Ding Sheng Xu Ren Wang Wei Xuan Ze-Yu Cao Jian Chen Hong-Hong Wu Mao-Bing Ye Wen-Biao Shen | 2009 | Journal of Integrative Plant Biology2009，51，10： | 14 |
| 4 | Experiment on Leader Propagation Characteristics of Air Gaps in UHVDC Transmission Towers Under Positive Switching Impulse Voltages显示文摘Rapid developments in EHV/UHV transmission systems require a deeper understanding of the mechanism of long air gap discharge.Leader propagation is one of the main processes in long gap breakdown.In this paper,the leader propagation characteristics of real size±800 kV UHVDC transmission tower gaps under positive switching impulse voltages(185/2290μs)are investigated.An integrated observation platform consisting of an impulse voltage divider,a coaxial shunt,a high-speed video camera,and a set of integrated optical electric field sensors(IOES),is established.The waveforms of impulse voltage,discharge current,electric field variation at specific positions,and time-resolved photographs of discharge morphology are recorded.Axial leader velocity and the relationship between leader advancements and injected charge are obtained.The typical value of leader stable propagation velocity is 1.7–2.2 cm/μs,which varies slightly with the gap length and applied voltage amplitude.The leader velocity in the re-illumination process is much higher,and is seen as varying from 5 cm/μs to 30 cm/μs,with an average value around 10 cm/μs.The charge in leader channel per unit length is 20–40μC/m,which illustrates a near-direct proportion relationship between discharge current and leader velocity.The observed parameters are important for further simulation of the tower gap breakdown processes. | Xuan Zhou She Chen Hai Wang Rong Zeng Chijie Zhuang Junjie Yu Yujian Ding | 2015 | CSEE Journal of Power and Energy Systems2015，1，3： | 12 |
| 5 | Removal of adhesive dusts from flue gas using corona discharges with spraying water显示文摘Effective removal of adhesive and fine dusts from flue gas is very difficult. A new method of electrostatic precipitation of the corona discharges with spraying water(CDSW) was introduced. A new electrode configuration and the circulation spraying of water were employed in the method. The efficient electrostatic precipitation for adhesive and fine dusts can be accomplished without any drain water during a long operating period. The fundamental structure, discharge characteristics, mechanism of spraying and precipitation principle of the electrostatic precipitation using CDSW were described and analyzed. The V I characteristics, spraying state, supplying water quantity, influence of temperature and clean of the electrodes were researched in series experiments. The treating effects of circulating spraying using the corona plasma at the same time of electrostatic precipitation were investigated. The fundamental theories and experimental data were proposed, in order to effectively remove the adhesive dusts from flue gas using CDSW in practice. | XU De\|xuan, ZHAO Jian\|wei, DING Yun\|zheng, GE Wei\|li (Department of Environmental Science and Engineering, Northeast Normal University, Changchun 130024, China. | 2003 | Journal of Environmental Sciences2003，15，4： | 11 |
| 6 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 7 | Three new alkaloids isolated from the stem tuber of Pinellia pedatisecta显示文摘The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids(compounds 1, 2, and 3) were obtained and identified as 9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-amine(1), 4-(2-(2, 5-dioxopyrrolidin-1-yl)ethyl)phenyl acetate(2), and N-(9-((5-methoxypyridin-2-yl)methyl)-9 H-purin-6-yl)acetamide(3). These compounds were evaluated for their cytotoxicity against human cervical cancer He La cells. Compounds 1 and 3 significantly inhibited the proliferation of He La cells with IC_(50) values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L^(-1), respectively. | DU Jing DING Jie MU Zhen-Qiang GUAN Shu-Hong CHENG Chun-Ru LIU Xuan GUO De-An | 2018 | Chinese Journal of Natural Medicines2018，16，2： | 10 |
| 8 | Experience of Clinical Management for Pregnant Women and Newborns with Novel Coronavirus Pneumonia in Tongji Hospital,China显示文摘Based on the New Diagnosis and Treatment Scheme for Novel Coronavirus Infected Pneumonia(Trial Edition 5),combined with our current clinical treatment experience,we recently proposed a revision of the first edition of“Guidance for maternal and fctal management during pneumonia epidemics of novel coronavirus infection in the Wuhan Tongji Hospital'.This article focused on the issues of greatest concern of pregnant women including severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection diagnostic criteria,inspection precautions,drug treatment options,indications and methods of termination of pregnancy,postpartum fever,breastfeeding considerations,mode of mother-to-child transmission,neonatal isolation and advice on nconatal nursing,to provide valuable experience for better management of SARS-CoV-2 infection in pregnant women and newborns. | Shao-shuai WANG Xuan ZHOU Xing-guang LIN Yan-yan LIU Jian-li WU Lali Mwamaka Shariful Xiao-lin HU Zhi-bui RONG Wei LIU Xiao-ping LUO Zhuo CHEN Wan-jiang ZENG Su-hua CHEN Ding MA Ling CHEN Ling FENG | 2020 | Current Medical Science2020，40，2： | 8 |
| 9 | Cadmium accumulation in different pakchoi cultivars and screening for pollution-safe cultivars显示文摘The selection and breeding of pollution-safe cultivars (PSCs) is a practicable and cost-effective approach to minimize the influx of heavy metal to the human food chain.In this study,both pot-culture and field experiments were conducted to identify and screen out cadmium pollution-safe cultivars (Cd-PSCs) from 50 pakchoi (Brassica rapa L.ssp.chinensis) cultivars for food safety.When treated with 1.0 or 2.5 mg/kg Cd,most of the pakchoi cultivars (>70%) showed greater or similar shoot biomass when compared with the control.This result indicates that pakchoi has a considerable tolerance to soil Cd stress.Cd concentrations in the shoot varied significantly (P<0.05) between cultivars:in two Cd treatments (1.0 and 2.5 mg/kg),the average values were 0.074 and 0.175 mg/kg fresh weight (FW),respectively.Cd concentrations in the shoots of 14 pakchoi cultivars were lower than 0.05 mg/kg FW.In pot-culture experiments,both enrichment factors (EFs) and translocation factors (TFs) of six pakchoi cultivars were lower than 1.0.The field studies further confirmed that the Hangzhouyoudonger,Aijiaoheiye 333,and Zaoshenghuajing cultivars are Cd-PSCs,and are therefore suitable for growth in low Cd-contaminated soils (≤1.2 mg/kg) without any risk to food safety. | Ying CHEN Ting-qiang LI Xuan HAN Zhe-li DING Xiao-e YANG Ye-fei JIN | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，6： | 7 |
| 10 | Os isotope dating and growth hiatuses of Co-rich crust from central Pacific显示文摘Up to now, accurate determination of the growth age and hiatuses of the Co-rich crust is still a difficult work, which constrains the researches on the genesis, growth process, controlling factors, regional tectonics, paleo-oceanographic background, etc. of the Co-rich crust. This paper describes our work in determining the initial growth age of the Co-rich crust to be of the late Cretaceous Campanian Stage (about 75-80 Ma), by selecting the Co-rich crust with clear multi-layer structures in a central Pacific seamount for layer-by-layer sample analysis and using a number of chronological methods, such as Co flux dating, dating by correlation with 187Os/188Os evolution curves of seawater, and stratigraphic divi- sion by calcareous nannofossils. We have also discovered growth hiatuses with different time intervals in the early Paleocene, middle Eocene, late Eocene and early-middle Miocene, respectively. These re- sults have provided an important age background for further researches on the Co-rich crust growth process and the paleo-oceanographic environment evolution thereby revealed in the said region. | LI JiangShan FANG NianQiao QU WenJun DING Xuan GAO LianFeng WU ChangHang ZHANG ZhenGuo | 2008 | Science China Earth Sciences2008，51，10： | 6 |
| 11 | Dihydromyricetin ameliorates chronic liver injury by reducing pyroptosis显示文摘BACKGROUND Chronic liver injury(CLI) is now a worldwide disease. However, there is no effective treatment. Pyroptosis plays an essential role in CLI. Dihydromyricetin(DHM) resists oxidation and protects the liver. We hypothesize that the beneficial effect of DHM on CLI is related to its effect on the expression of pyroptosisrelated molecules. Therefore, we studied the influence of DHM on CLI and pyroptosis.AIM To study the role of pyroptosis in the pathogenesis of CLI and the therapeutic mechanism of DHM.METHODS Thirty-two mice were randomly divided into four groups: The control group was injected with olive oil, the carbon tetrachloride(CCl4) group was injected with CCl4, the vehicle group was injected with hydroxypropyl-β-cyclodextrin while injecting CCl4 and the DHM group was injected with DHM while injecting CCl4. After four weeks of treatment, liver tissues from the mice were stained with hematoxylin and eosin, and oil red O. Blood was collected from the angular vein for serological analysis. The severity of CLI was estimated. Some liver tissue was sampled for immunohistochemistry, Western blotting and quantitative reverse transcription PCR to observe the changes in pyroptosis-related molecules.RESULTS Serum total cholesterol, low density lipoprotein, aspartate aminotransferase(AST) and alanine aminotransferase(ALT) in the CCl4 group were higher than those in the control group, and serum total cholesterol, low density lipoprotein, AST and ALT in the DHM group were lower than those in the vehicle group. Hematoxylin and eosin and oil red O staining showed that there were more lipid droplets in the CCl4 group than in the control group, and there were fewer lipid droplets in the DHM group than in the vehicle group. Western blotting showed that the expression of the pyroptosis-related molecules caspase-1, NOD-, LRR-and pyrin domain-containing 3(NLRP3) and gasdermin D(GSDMD)-N in the CCl4 group was higher than that in the control group, while expression of these proteins in the DHM group was lower than that in the vehicle group. Quantitative reverse transcription PCR results showed that the expression of the pyroptosis-related genes caspase-1, NLRP3, GSDMD and interleukin-1β(IL-1β) in the CCl4 group was higher than that in the control group, while there was no significant change in NLRP3 and caspase-1 expression in the DHM group compared with that in the vehicle group, and the expression of GSDMD and IL-1β was decreased.CONCLUSION DHM improves CCl4-induced CLI and regulates the pyroptosis pathway in hepatocytes. DHM may be a potential therapeutic agent for CLI. | Quan-Cheng Cheng Jing Fan Xin-Wei Deng Huai-Cun Liu Hui-Ru Ding Xuan Fang Jian-Wei Wang Chun-Hua Chen Wei-Guang Zhang | 2020 | World Journal of Gastroenterology2020，26，41： | 5 |
| 12 | Site-specific pharmaco-laser therapy:A novel treatment modality for refractory port wine stains显示文摘Despite extensive efforts to optimize laser therapy,i.e.,the current gold standard treatment,a majority of port wine stain(PWS)patients responds suboptimally to laser therapy.This paper describes the niceties of a novel PWS treatment modality termed site-specific pharmaco-laser therapy(SSPLT).In contrast to the classic approach of enhancing the extent of intravascular photocoagulation(the photothermal response),SSPLT focuses on optimization of post-irradiation thrombus formation(i.e.,the hemodynamic response)by combining conventional laser therapy with the administration of thermosensitive drug delivery systems that encapsulate prothrombotic and antifibrinolytic drugs.The aim of SSPLT is to instill complete lumenal occlusion in target vessels,which has been linked to optimal PWS blanching.Relevance for patients:The current treatment options for PWS patients are limited in efficacy.Novel therapeutic modalities are needed to more effectively treat patients with recalcitrant PWSs.SSPLT is an experimental-stage treatment modality that could serve as an adjuvant to pulsed dye laser therapy for a selected group of patients whose PWS is ill-responsive to standard treatment.The expected clinical result of SSPLT is improved lesional blanching. | M.Ingmar van Raath Jojanneke E.van Amesfoort Martin Hermann Yasin Ince Maurice J.Zwart Agustina V.Echague Yan Chen Baoyue Ding Xuan Huang Gert Storm Michal Heger | 2019 | Journal of Clinical & Translational Research2019，5，1： | 4 |
| 13 | Granular porous calcium carbonate particles for scalable and high-performance solar-driven thermochemical heat storage显示文摘Calcium carbonate is promising thermochemical heat storage material for next-generation solar power systems due to its high energy storage density,low cost,and high operation temperature.Researchers have tried to improve energy storage performances of calcium carbonate recently,but most researches focus on powders,which are not suitable for scalable applications.Here,novel granular porous calcium carbonate particles with very high solar absorptance,energy storage density,abrasive resistances,and energy storage rate are proposed for direct solar thermochemical heat storage.The average solar absorptance is improved by 234%compared with ordinary particles.Both cycle stability and abrasive resistances are excellent with almost no decay of energy storage density over 25 cycles nor apparent particle weight loss over 24 h of continuous operation insides a planetary ball mill.In addition,the decomposition temperature is reduced by 2.8%–5.6%while the reaction rate of heat storage is enhanced by 80%–205%depending on the CO_(2) partial pressure.The decomposition process of doped granular porous CaCO_(3) particles is found to involve three overlapping processes.This work provides new routes to achieve scalable direct solar thermochemical heat storage for next-generation high-temperature solar power systems. | SONG Chao LIU XiangLei XUAN YiMin ZHENG HangBin GAO Ke TENG Liang DA Yun LI Chuan LI YongLiang DING YuLong | 2021 | Science China(Technological Sciences)2021，64，10： | 4 |
| 14 | Molecular dynamics simulation and continuum modelling of granular surface flow in rotating drums显示文摘Numerical simulations of granular flows in rotating drums operated at medium to high rates (Fr=0.1― 0.2) have been carried out by using a Molecular Dynamics (MD) algorithm that incorporates inelastic particle interactions, sliding friction and rolling friction. The results indicate that the behavior of granular flow in rotating drums can be classified into two distinct zones: a shear active layer at the bed surface and a quasi-static plug flow region adjacent to the wall. The residence time of a tracer particle in the active layer is approximately a third or a half of that in the plug flow region. The thickness of the active layer at mid-chord is about 0.57―0.61 times that of the plug flow region. It is found that all cases simulated in this work are in the rolling-cascading intermediate regime instead of the pure rolling re-gime. The simulated tangential velocity at the mid-chord is also compared with experimental results reported in the literature and good agreement has been obtained. Based on the MD simulations and experimental results, a continuum approach has also been developed. It is shown that the behavior of granular solids in the plug flow region experiences plastic deformation along the radial direction from the wall with the velocity profiles well described by an exponential function, whereas the active layer velocity follows a simple expression for the Couette shear flow. Discussion has also been made on the granular temperature and concentration profiles. | LI ShuiQing YAO Qiang CHEN Bing ZHANG Xuan DING Y L | 2007 | Chinese Science Bulletin2007，52，5： | 3 |
| 15 | In-situ study on hydrogen bubble evolution in the liquid Al/solid Ni interconnection by synchrotron radiation X-ray radiography显示文摘Synchrotron X-ray radiography was used to carry out an in-situ observation of the hydrogen bubble evolution in the liquid Al/solid Ni interconnection. The individual bubble mainly grows in a stochastic way during heating. The size distribution for groups of bubbles follows a Gaussian distribution in the early stage and Lifshitz-Slyozov-Wagner(LSW) diffusion controlled distribution in the final stage. The intermetallic compounds(IMCs) first form during solidification, following by the hydrogen bubbles. The bubbles between two adjacent Al3Ni grains grow unidirectionally along the liquid channel, with the bottom being impeded by the Al3Ni phase and the radius of the growth front being smaller. For the bubbles at triple junctions, they grow along the liquid channel and the crack with morphology transition. | Zongye Ding Qiaodan Hu Wenquan Lu Xuan Ge Sheng Cao Siyu Sun Tianxing Yang Mingxu Xia Jianguo Li | 2019 | Journal of Materials Science & Technology2019，35，7： | 3 |
| 16 | Prolonged chronic phase in chronic myelogenous leukemia after homoharringtonine therapy显示文摘 | LI Yu-feng DENG Zhi-kui XUAN Heng-bao ZHU Jia-bin DING Bang-he LIU Xiao-ning CHEN Bao-an | 2009 | Chinese Medical Journal2009，，12： | 3 |
| 17 | The relationship between the growth process of the ferromanganese crusts in the Pacific seamount and Cenozoic ocean evolvement显示文摘Base on the Os isotope stratigraphy together with the empirical growth rate models using Co concentrations, the growth ages of the ferromanganese crusts MHD79 and MP3D10 distributed in the seamount of Pacific are confirmed. Through the contrast and research on the previous achievements including ODP Leg 144 and the crusts CD29-2, N5E-06 and N1-15 of the seamount of the Central Pacific, the uniform five growth and growth hiatus periods of them are found, and closely related to the Cenozoic ocean evolvement process. In the Paleocene Carbon Isotope Maximum (PCIM), the rise of the global ocean productivity promoted the growth of the seamount crust; the first growth hiatus (I) of the ferromanganese crust finished. In the Paleocene-Eocene Thermal Maximum (PETM), though the vertical exchange of seawater was weakened, the strong terrestrial chemical weathering led to the input of a great amount of the terrigenous nutrients, which made the bioproductivity rise, so there were no crust hiatuses. During 52-50 Ma, the Early Eocene Optimum Climate (EECO), the two poles were warm, the latitudinal temperature gradient was small, the wind-driven sea circulation and upwelling activity were weak, the terrestrial weathering was also weakened, the open ocean bioproductivity decreased, and the ferromanganese crust had growth hiatus again (II). From early Middle Eocene-Late Eocene, Oligocene, it was a long-term gradually cooling process, the strengthening of the sea circulation and upwelling led to a rise of bioproductivity, and increase of the content of the hydrogenous element Fe, Mn and Co and the biogenous element Cu, Zn, so that was the most favorable stage for the growth of ferromanganese crust (growth periods III and IV) in the studied area. The hiatus III corresponded with the Eocene-Oligocene boundary, is inferred to relate with the global climate transformation, celestial body impact event in the Eocene-Oligocene transition. From the early to the middle Miocene, a large-scale growth hiatus (hiatus period IV) of the ferromanganese crust in the studied area is inferred to relate with temporary warm up climate and ephemeral withdrawal of Antarctic bottom water in the early Miocene. After that, the Antarctic ice sheets extended, the bottom water circumfluence strengthened, the ocean fertility increased, and the once interrupted crust continued to grow in the late Miocene (growth period V). | DING Xuan GAO LianFeng FANG NianQiao QU WenJun LIU Jian LI JiangShan | 2009 | Science China Earth Sciences2009，52，8： | 2 |
| 18 | High-performance Zn-graphite battery based on LiPF6 single-salt electrolyte with high working voltage and long cycling life显示文摘Zinc-ion batteries(ZIBs) are promising alternative energy storage devices to lithium-ion batteries owing to the merits of large abundance,high theoretical capacity,and environmental friendliness.However,critical challenges including low working voltage(below 2 V),low energy density as well as dendrites formation during long cycling caused by aqueous ZIB systems still hinder their practical applications.Herein,a high-voltage Zn-graphite battery(ZGB) based on a non-zinc ion single-salt electrolyte(2.5 M LiPF6 in carbonate solvent) is developed.Moreover,we surprisingly found that Zn^(2+) is dissolved in the LiPF6 single-salt electrolyte during resting and discharging processes,thus enabling reversible Zn plating/stripping mechanism on the Zn foil anode in the ZGB over the voltage window of 1.0-3.1 V.As a result,the ZGB achieves long-term cycling performance with a capacity retention of ~100% for over1200 cycles at 3 C and high Coulombic efficiency of ~100% in 1.0-3.1 V with no dendrites formation.Moreover,the ZGB exhibits a high working voltage of up to 2.2 V,thus contributing to both high energy density(up to 210 Wh kg^(-1)) and high power density(up to 1013 W kg^(-1)),superior than most reported ZIBs. | Yong Wang Luojiang Zhang Fan Zhang Xuan Ding Kyungsoo Shin Yongbing Tang | 2021 | Journal of Energy Chemistry2021，30，7： | 2 |
| 19 | Self-immolative micellar drug delivery:The linker matters显示文摘Redox-responsive polymer-drug conjugate micelles are excellent nanoscale vehicles for self-immolative intracellular drug delivery.To covalently connect the polymer and drug,disulfide-bearing linkers,such as 3,3'-dithiodipropionic acid (DDPA) and 4,4'-dithiodibutyric add (DDBA),are used.In this paper,we report the influence of linker length on the therapeutic outcome of redox-sensitive conjugate micelles.Curcumin was selected as the model drug and it was conjugated to a multivalent methoxy poly(ethylene glycol)-polylysine copolymer with DDPA or DDBA as the linker.The obtained two polymer-curcumin conjugates were amphiphilic and could self-assemble into micelles that have a hydrodynamic diameter less than 100 nm.The loading of curcumin in both micelles was above 20% (w/w).Irrespective of the linker type,micelle disassembly was observed due to the collapse of the disulfide bond in a reducing environment.However,the rate of curcumin release was much faster with the DDBA linker than with the DDPA linker as the side product was a 5-membered ring with a low ring strain.The linker length-induced variation of curcumin release kinetics caused a significant difference in the intracellular drug concentration and a higher cytotoxicity was witnessed in three model cell lines (HeLa,PC3,and 4T1) for the micelles with a DDBA linker compared to those containing a DDPA linker.As expected,this phenomenon was also observed in HeLa tumor-bearing nude mice in vivo.The current work highlights the significance of linker length in engineering redox-responsive on-demand delivery systems. | Xuan Meng Min Gao Jian Deng Di Lu Aiping Fan Dan Ding Deling Kong Zheng Wang Yanjun Zhao | 2018 | Nano Research2018，11，12： | 2 |
| 20 | Rapid Climatic Change during Past 60 ka Recorded in NE Indian Ocean and Its Correspondence from South China Land显示文摘According to the marine records from the Bay of Bengal, northeastern Indian Ocean, and the continental records from the South China, the authors make a detailed discussion in this paper about the correlation between them and their implication of rapid climatic change. The marine records show its good response to the high latitudes both for cold events and for warm ones while the continental records mainly mirror those cold Heinrich events corresponding to the North Atlantic but bear strongly a local color in reflecting warm events. The authors assume that the heat transmission style may cause the unbalanced coupling relationship. | Fang Nianqiao Chen Xuefang Hu Chaoyong Yin Yong Ding Xuan Zhang Shihong Nie Haogang Institute of Marine Geology and Geophysics, China University of Geosciences, Beijing 100083, China | 2000 | Journal of Earth Science2000，19，3： | 2 |
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