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| 1 | Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus—Sichuan Province,China,2019显示文摘What is already known about this topic?After the type 2 strain of the live,attenuated poliovirus vaccine was withdrawn globally in 2016,any identification of a type 2 poliovirus is a Public Health Emergency of International Concern.A vaccinederived type 2 poliovirus(VDPV2)was identified in Sichuan,prompting an urgent,comprehensive investigation and response.What is added by this report?Type 2 monovalent,live,attenuated oral poliovirus vaccine(mOPV2)is being used to respond to the numerous VDPV2 outbreaks seen around the world.In contrast,the response in Sichuan used Sabin strain inactivated poliovirus(sIPV)to stop circulation of the VDPV2.In the 6 months following the vaccination response,there have been no VDPV2s detected in Sichuan,despite extensive search.What are the implications for public health practices?Further search for the VDPV2 must continue in order to determine whether transmission has been stopped.The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks. | Jiushun Zhou Ning Wen Yong Zhang Qi Qi Chunxiang Fan Dongmei Yan Xiaoping Zhu Lixin Hao Shuangli Zhu Yu Liu Xiaozhen Ma Chao Ma Lei Nan Yong Chen Qianli Ma Cheng Wang Kun Deng Lei Cao Ge Shao Xianxiang Ding Hong Yang Zhijie An Lance ERodewald Aiqiang Xu Huaqing Wang Zijian Feng Zundong Yin Xianping Wu Wenbo Xu | 2020 | China CDC weekly2020，2，11： | 3 |
| 2 | Review on corrosion resistance of mild steels in liquid aluminum显示文摘The corrosion of mild steels by liquid aluminum is an intractable issue in aluminum industry.This review aims to provide an overview of the corrosion behavior of mild steels in the static liquid aluminum with an emphasis on the thermodynamic and kinetic aspects.The corrosion mechanisms of mild steels in liquid aluminum are discussed systematically,based on which four corrosion control approaches including alloying,introducing secondary phase,matrix microstructure control and surface treatment are introduced.Currently,a combination of improvement approaches may have a great potential for further enhancement in corrosion resistance. | Gaopeng Xu Kui Wang Xianping Dong Lei Yang Mahmoud Ebrahimi Haiyan Jiang Qudong Wang Wenjiang Ding | 2021 | Journal of Materials Science & Technology2021，，12： | 1 |
| 3 | Sequence Variations Analysis of HPV-18 Isolates in Southwest China显示文摘 | SHEN Mengjie DING Xianping | 2013 | PLoS One2013，8，2： | 1 |
| 4 | 肺腺癌实性结节肿瘤间质与多排螺旋CT早期增强间的关系研究(英文)显示文摘Objective: To evaluate correlations between proportion and distribution of tumor stroma and MDCT early phase enhancement character in solid lung adenocarcinoma, and compare with microvessel density and histological subtypes. Methods: Thirty-one patients with lung adenocarcinoma shown as solid solitary pulmonary nodules underwent routine con-trast-enhanced MDCT followed by surgical resections. CT character included net enhancement and distribution of enhance-ment. The largest cut surface of tumor specimens were stained by hematoxylin and eosin. About 25 fields of view of each specimen were scanned as digitized pictures at low magnification. Semi-auto segmentation software was used to calculate mean stroma proportion. Pearson correlation coefficient was used to represent the relationships between extent of tumor en-hancement, proportion of tumor stroma and MVD respectively. Fisher's exact test was used to analyze statistical differences in degree of CT enhancement among groups of different histological subtypes. Results: Proportion of invasive tumor stroma (13.2%-54.5%, mean 26.2 ± 8.8%) was correlated positively with net enhancement (8-60.8 HU, mean 31.2 ± 13.6 HU; r = 0.483, P = 0.006) which was more than MVD. 58.1% cases showed homogenous enhancement, 32.3% cases showed periph-eral inhomogenous enhancement, 3.2% cases showed central inhomogenous enhancement, 3.2% cases showed asymmetri-cal inhomogenous enhancement, and 3.2% cases showed no enhancement. 58.1% cases' stroma showed mixed distribution, 35.5% cases showed peripheral distribution, 3.2% cases showed central distribution, and 3.2% cases showed asymmetrical distribution. Significantly more adenocarcinomas classified with 'net enhancement > 20 HU' were found in the acinar group than in the solid with mucin subtype (P = 0.005). Conclusion: Extent of CT enhancement reflects underlying not only the tumor angiogenesis but also stroma proliferation in solid small lung adenocarcinoma. Tumor stroma proportion could reflect the histopathologic basis of small lung adenocarcinoma's CT enhancement substantially than MVD. Distribution between enhancement and tumor stroma have good correspondence. Most of acinar adenocarcinomas have higher degree of CT net enhancement than solid with mucin adenocarcinomas. | Yong Wang Xueguo Liu Yujing Lin Xianping Yi Lianju Ding Xiaohong Wang Qjngsi Zeng Jianxing He Mingzhu Liang Peixin Qin Guomei Zhong Yanli He Xiaobin Liu | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，5： | 0 |
| 5 | Age-related changes in prevalence and symptom characteristics in kidney deficiency syndrome with varied health status:a cross-sectional observational study显示文摘Objective:This study aimed to reveal the age-related changes in prevalence and symptom characteristics in kidney deficiency syndrome(KDS)with varied health status.Methods:This cross-sectional observational study was conducted in6 hospitals.Investigators queried participants aged 20e79 about their health,including symptoms if any,and completed questionnaires to collect participants responses.Prevalence,severity,and frequency of KDS and other relevant parameters were observed and recorded.Comparative analysis of countable variables,including prevalence,was performed by frequency analysis and c2 test and expressed as a composite ratio.Comparative analysis of quantitative scores of the severity and frequency of symptoms was performed by the rank-sum test.Regression analysis of the correlation of KDS with potential contributing factors was performed by non-conditional binary logistic stepwise regression of numerical variables.Results:Prevalence of KDS in healthy and unhealthy participants correlated with increasing age(P<0.05).In those with chronic disease,KDS prevalence was comparatively high,but the trend was not obvious.KDS prevalence in participants age 20e39 showed an increasing trend with deteriorating health(P<0.05).Compared to healthy individuals,KDS prevalence in subhealthy persons and those with chronic disease showed an increasing trend(P<0.05)in the 40e59 and 60e79 age groups,whereas there was no difference between subhealthy persons and those with chronic disease age 40e59 and 60e79.Symptom severity scores of KDS showed an increasing trend with increasing age and deteriorating health status(P<0.05).Higher symptom frequency scores were also positively correlated with increasing age(P<0.05),but health status deterioration was not significantly correlated(P>0.05).Age,health status,lower back pain,shin soreness or heel pain,tinnitus or deafness,hair loss or loose teeth,incomplete bladder emptying or incontinence,and sexual dysfunction or infertility were potential factors contributing to KDS(P<0.05),but age was the only independent variable for which OR>1.Moreover,the distribution of typical KDS-related symptoms showed dramatic regularities.Conclusion:Prevalence and symptom characteristics of KDS were found to increase consistently with increasing age and deteriorating health status.Kidney deficiency may be an important mechanism of aging in the subhealthy and chronic disease states. | Yin Zhang Yue Liu Xianping Li Yuezhou Chen Hui Ye Xiaofeng Li Zihan Lin Zheng Wang Wei Huang Xia Ding | 2014 | Journal of Traditional Chinese Medical Sciences2014，1，1： | 0 |
| 6 | Stabilization of MYC G-quadruplex DNA by ruthenium(II)complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation显示文摘The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance. | Yuening Sun Xin Chen Siyan Liao Aochu Liu Huan Zhou Liling Jiang Wa Ding Wenjie Mei Jinbao Liu Xianping Shi | 2023 | Genes & Diseases2023，10，2： | 0 |
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