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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Molecular markers(PECAM-1,ICAM-3,HLA-DR)determine prognosis in primary non-Hodgkin's gastric lymphoma patients显示文摘瞄准:与主要 non-Hodgkin 的胃的淋巴瘤在病人调查 PECAM-1, ICAM-3 和 HLA 医生抗原的预示的意义。方法:我们免疫组织化学地在 36 个 B 房间麦芽类型主要胃的淋巴瘤病人学习了 PECAM-1, ICAM-3 和 HLA 医生抗原表示。十非恶意并且十个健康胃的织物标本被用作控制。Clinicopathological 和幸存数据与染色的结果被相关。结果:HLA 医生抗原表示在 33 个胃的淋巴瘤病人(91.7%) 和 6 个非恶意的病人(54.5%) 被检测。PECAM-1 染色了 10 个病人(27.8%) 的肿瘤房间, 9 个病人(25%) 的 endothelial 并且煽动性有良性的胃的疾病的 4 个病人(40%) 渗入。ICAM-3 表示在 17 个病人(47.2%) 的肿瘤房间上被观察,当 5 个非恶意的病人(50%) 被染色时积极也。任何一个都没为任何学习的基因健康控制被染色。在里面多,变量分析, HLA 医生抗原和 PECAM-1 被证明是与联系的统计上重要的独立预示的因素一赞成并且不利预后分别地(P=0.009 和 P=0.003 ) 。在 univariate 分析, PECAM-1 (+)/ICAM-3 (-) 和 HLA 医生(-)/ICAM-3 (-) 病人与确切相反的基因表示模式与那些相比展出了显著地减少的全面幸存(P=0.0041 和 P=0.0091,分别地) 。是 HLA 医生(+)/ICAM-3 (+)/PECAM-1 (-)(n=8 ) 的那些病人让显著地更高的幸存与这个组(n=24 )(P=0.0289 ) 的其余部分相比评价。结论:PECAM-1, ICAM-3 和 HLA 医生分别地是肿瘤扩大潜力和主人免疫者监视的代表性的标记。他们的联合使用可以帮助我们识别能得益于更好攻击的治疗学的协议的高风险的病人。 | Alexander Darom Ilias P Gomatos Emmanuel Leandros Emmu Chatzigianni Dimitris Panousopoulos Manousos M Konstadoulakis George Androulakis | 2006 | World Journal of Gastroenterology2006，12，12： | 4 |
| 3 | Continuous nearest neighbor queries over sliding windows 显示文摘 | M Kyriakos P Dimitris | 2007 | IEEE Transactions on Knowledge and Data Engineering2007，19，6： | 1 |
| 4 | Structure and composition of sweet sorghum stalk components 显示文摘 | Evaggeli B Dimitris P K Bernard M | 1997 | Industrial Crops and Products1997，，6： | 1 |
| 5 | Stress tolerance of five willow clones after irrigation with different amounts of landfill leachate 显示文摘 | DIMITRIOU I ARONSSON P WEIH M | 2006 | Bioresour Technol2006，97，： | 1 |
| 6 | Long-term synaptic plasticity in hippocampal interneurons 显示文摘 | Dimitri M Kullmann Karri P Lamsa | 2007 | Neuroscience2007，8，9： | 1 |
| 7 | Long-term synaptic plasticity in hippocampal interneurons 显示文摘 | Dimitri M Kullmann Karri P Lamsa | 2007 | Neuroscience2007，8，9： | 1 |
| 8 | FSH receptor gene polymorphisms have a role for different ovarian response to stimulation in patients entering IVF/ICSI-ET programs 显示文摘 | Dimitris L Eleni P Vassilis M | 2006 | J of Assist Reprod Genet2006，23，4： | 1 |
| 9 | Mechanism for action of electromagnetic fields on cells显示文摘 | Dimitris J P Andreas K Lukas H M | 2002 | Biochemical and Biophysical Research Communications2002，298，： | 1 |
| 10 | 1979 -2001: A Greek Great Depression Through the Lens of Neoclassical Growth Theory 显示文摘 | Stylianos G G Nikolaos M Dimitris P | 2014 | Economic Modelling2014，36，： | 1 |
| 11 | Oxidative stress as a common mediator for apoptosis induced-cardiac damage in diabetic rats显示文摘 | Mohammad M D Dimitri P M Mohamed A H | 2008 | Open Cardiovascular Med2008，2，： | 1 |
| 12 | Domestic processing of oion bulbs (Allium cepa)and asparagus spears (Asparagus officinalis): effect on flavonol content and antioxidant status显示文摘 | DIMITRIS P M ROSSITER J T | 2001 | Jounal of Agricalture and Food Chemistry2001，49，7： | 1 |
| 13 | Refinery shortterm scheduling with tank farm, inventory and distillation management: an integrated simulation-based approach显示文摘 | GEORGE C NIKOLAOS P DIMITRIS M | 2005 | European Journal of Operational Research2005，166，3： | 1 |
| 14 | Top-k spatial joins 显示文摘 | Zhu M L Dimitris P | 2005 | IEEE Transactions on knowledge and data engineering2005，17，4： | 1 |
| 15 | Antiproliferative Activity of Greek Propolis显示文摘 | Harris P Dimitris K Eleni M | 2010 | Journal of Medicinal Food2010，13，2： | 1 |
| 16 | Quantify- ing the spoilage and shelf-life of yoghurt with fruits显示文摘 | MATARAGAS M DIMITRIOU V SKANDAMIS P N | 2010 | Food Microbiol2010，28，3： | 1 |
| 17 | Structure and composition of sweet Sorghum components显示文摘 | Evaggeli B Dimitris P K Bernard M | 1997 | Industrial Crops and Products1997，6，3： | 1 |
| 18 | Indications for familial screening and gonadectomy in patients with 46, XY gonadal dysgenesis 显示文摘 | Dimitri P Cohen M Wright N | 2006 | Int J Gynaecol Obstet2006，95，2： | 1 |
| 19 | Stress tolerance of five willow clones after irrigation with different amounts of landfill leachate 显示文摘 | DIMITRIOU I ARONSSON P WEIH M | 2006 | Bioresource Technology2006，97，： | 1 |
| 20 | Structure and composition of sweet sorghum stalk components 显示文摘 | Evaggeli B Dimitris P K Bernard M | 1997 | Industrial Crops and Products1997，，6： | 1 |
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