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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | Compositional characterisation of some apple varieties显示文摘 | A. Pods?dek J. Wilska-Jeszka B. Anders J. Markowski | 2000 | European Food Research and Technology2000，，4： | 3 |
| 4 | The Prague Linguistic Circle during the Second World War显示文摘The study focuses on the difficult situation of the Prague Linguistic Circle(PLC) during the Second World War(WWⅡ). Despite the decrease of publication possibilities and censorship in the first years of WWⅡ the activities of the Circle did not substantially change: meetings and lectures went on and also Slovo a slovesnost( Word and Verbal Art) was published until 1943. Nevertheless,a certain decrease of activities came in 1944.In general,during WWⅡ the Circle was one of fewcenters of Czech scholarly effort and thanks to it several key individual works of Vilém Mathesius,Jan Mukaovsky,Bohuslav Havrnek,Jií Veltrusky,Vladimír Skalicka etc. and collective books such as Torso a tajemství Máchova díla(The Fragment and Mystery of Mácha's Work),tení o jazyce a poesii( Reading on Language and Literature) were published. These works significantly helped to preserve a continuity of an important research tradition of the Czech Structuralism,and influenced a further development of Czech linguistics,as well as Czech literary criticism, aesthetics, and theatre studies. The present study focuses also on Jan Mukaovsky's activities during WWⅡ and on his works published at that time. | Ondej Sldek | 2017 | 中国比较文学2017，，3： | 2 |
| 5 | Resveratrol attenuates lipopolysaccharide-induced hepatitis in d -galactosamine sensitized rats: Role of nitric oxide synthase 2 and heme oxygenase-1显示文摘 | Hassan Farghali Dalibor ?erny Ludmila Kameníková Jind?ich Martínek Ale? Ho?ínek Eva Kmoní?ková Zdeněk Zídek | 2009 | Nitric Oxide2009，，3： | 2 |
| 6 | Disruption of the actin cytoskeleton of mammalian cells by the capping complex action-fragment is inhibited by actin phosphorylation and regulated by Ca2+ ions显示文摘 | CONSTANTIN B MEERSCHAERT K VAN DEK ERCKHOVE J | 1998 | J Cell Sci1998，111，： | 1 |
| 7 | Evaluation of functional diversity of soil microbial eommunities-a case study显示文摘 | HOFMAN J SVIH DEK J HOLOUBEK I | 2004 | Plant and Soil Environment2004，50，4： | 1 |
| 8 | Flow cytometric immunobead assay for fast and easy detection of PML-RARA fusion proteins for the diagnosis of acute promyelocytic leukemia显示文摘 | Dekking EH van der Velden VH Varro R | 2012 | Leukemia2012，26，9： | 1 |
| 9 | Hypolipidemic and antioxidant effects of hydroxycinnamic acids,quercetin,and cyanidin 3-glucoside in hypercholesterolemic erythrocytes (in vitro study)显示文摘 | DUCHNOWICZ P BRONCEL M PODS?DEK A | 2012 | European Journal of Nutrition2012，51，4： | 1 |
| 10 | 基体结构和缺陷尺寸分布改性对聚乙烯醇纤维增强工程水泥基复合材料(PVA-ECC)挠度硬化行为的影响(英文)显示文摘研究了聚乙烯醇纤维增强工程水泥基复合材料(PVA-ECC)在四点弯曲载荷作用下的多重开裂和挠度硬化性能,设计了不同粘结剂组合和水胶比(W/B)(0.44~0.78)的矩阵,使PVA纤维得到了较好的分散。通过在混合物中加入直径为3 mm的聚乙烯微球(总体积为6%),比较研究了预先存在的缺陷尺寸分布修正对挠度硬化行为的影响。通过横断面分析,确定了无珠复合材料的自然缺陷尺寸分布。对弯曲加载后试件的裂纹数和裂纹宽度分布进行了表征,并讨论了缺陷尺寸分布改性引起多次裂纹和挠度硬化行为变化的可能原因。在W/B=0.53的条件下制备了含偏高岭土和缺陷尺寸分布改性的PVA-ECC,得到了较好的挠度硬化行为。分析了W/B比和超增塑剂含量对缺陷尺寸分布、潜在开裂、和纤维-基体粘结行为的双重作用。在优化的W/B比下,发现了有利于改善延展性的尺寸分布修正。 | Kamile TOSUN FELEKOĞLU Eren GÖDEK | 2019 | Journal of Central South University2019，26，12： | 1 |
| 11 | A Markov chain model for subsurface characterization: Theory and applications显示文摘 | Elfeki A Dekking M | 2001 | Mathematical Geology2001，33，5： | 1 |
| 12 | Insight into the cir-cadian clock within rat colonic epithelial cells显示文摘 | Sládek M Rybová M Jindráková Z | | 0，，04： | 1 |
| 13 | On the behaviour of the penetration twin abundance on {100{ diamond facets显示文摘 | Knuyt G Nesla'dek M Quaeyhaegens C | 1998 | Diamond and Related Materials1998，7，8： | 1 |
| 14 | A Markov Chain Model for subsurface characterization theory and applications 显示文摘 | Elfeki A Dekking M | | Mathematical Geology0，33，5： | 1 |
| 15 | Monitoring of inf lammation in patients on dialysis:forewarned is forearmed显示文摘 | Meuwese CL St envin kel P Dek ke r FW e t a l | 2011 | Nat Rev Nephrol2011，7，3： | 1 |
| 16 | Subthalamic nucleus involvement in executive functions with increased cognitive load: a subthalamic nucleus and anterior cingulate cortex depth recording study 显示文摘 | Aulicka SR JurOr k P Chla dek J | 2014 | Journal of neural transmission2014，121，10： | 1 |
| 17 | Matrix effects on the stability and antioxidant activity of red cabbage anthocyanins under simulated gastrointestinal digestion显示文摘 | Podsdek A Redzynia M Klewicka E | 2014 | Bio Med Research International2014，，： | 1 |
| 18 | Procyanidins from Evening Primrose (Oenothera paradoxa) Defatted Seeds Inhibit Invasiveness of Breast Cancer Cells and Modulate the Expression of Selected Genes Involved in Angiogenesis, Metastasis, and Apoptosis显示文摘 | Urszula Lewandowska Karolina Szewczyk Katarzyna Owczarek Zbigniew Hrabec Anna Pods?dek Dorota Sosnowska El?bieta Hrabec | 2013 | Nutrition and Cancer2013，，8： | 1 |
| 19 | Functional analysis of luxS in theprobiotic strain Lactobacillus rhamnosus GG reveals acentral metabolic role important for growth and biofilmformation 显示文摘 | LEB EER S deK EER SM A EC K ER SC J V ER H O -EVEN T L A | 2007 | Journal of Bacteriology2007，189，3： | 1 |
| 20 | Extending the shelf life of fresh sweet corn by shrink wrapping, refrigeration, and irradiation 显示文摘 | Dek T Heaton E K Hung Y C etal | 1987 | Journal of Food Science1987，52，6： | 1 |
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