|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | 显示文摘 | Lima M D de Andrade M J Bergmann C P | 2008 | J Mater Chem2008，18，： | 1 |
| 4 | One-step RT-PCR protocols improve the rate of dengue diagnosis com- pared to two-step RT-PCR approaches显示文摘 | De Paula S O D Lima C D M Torres M P | 2004 | J Clin Virol2004，30，： | 1 |
| 5 | Adsorption modeling of Cr,Cd and Cu on activa- ted carbon of different origins by using fractional factorial design 显示文摘 | De Lima L S Araujo M D M QuinOia S P | 2011 | Chemical Engineering Jour- nal2011，166，3： | 1 |
| 6 | A Mathematical model for evaluating the effect of wind on downward-spraying rainfall simulators显示文摘 | De Lima J L M P Torfs P J J F Singh V P | 2002 | Catena2002，46，4： | 1 |
| 7 | A Fuzzy Modcl for Function Point Analysis to Development and Enhancement Project Assessments显示文摘 | de Souza Lima Júnior O Farias P P M Belchior AD | 1990 | CLEI Electronic Journal1990，5，2： | 1 |
| 8 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 9 | Financial disintermediation and the measurem~ 显示文摘 | Lima F Soares de Pinho P | 2008 | International Journal of Banking Accounting and Finance2008，，2： | 1 |
| 10 | Candida albicans allergen immunotherapy in recurrent vaginal candidiasis显示文摘 | MORAES P S DE LIMA GOIABA S TAKETOMI E A | 2000 | J Investig Allergol Clin Immunol2000，10，： | 1 |
| 11 | Experimental and mechanical model for predicting the behaviour of minor axis beam-to-column semi-rigid joints 显示文摘 | de Lima L R O de Andrade S A L da S Vellasco P C G | 2002 | International Journal of Mechanical Science2002，44，6： | 1 |
| 12 | Chemical and morphological characterization of sugarcane bagasse submitted to a delignification process for enhanced enzymatic digestibility 显示文摘 | REZENDE C A de LIMA M A MAZIERO P DEAZEVEDO E R GARCIA W POLIKARPOV L | 2011 | Biotechnology for Biofuels2011，4，1： | 1 |
| 13 | Prognostic impact of MUM1 expression by immunohistochemistry on primary mediastinal large B- cell lymphoma显示文摘 | DE MELLO C A DE ANDRADE V P DE LIMA V C | 2011 | Leuk Lymphoma2011，52，： | 1 |
| 14 | High risk of graft failure in patients with anti - HLA antibodies undergoing haploidentical stem - cell transplantation 显示文摘 | Ciurea SO de Lima M Cano P | 2009 | Transplan- tation2009，88，8： | 1 |
| 15 | GP3 is a structural component of the PRRSV type II(US)virion显示文摘 | De Lima M Ansari I H Das P B | 2009 | Virology2009，390，1： | 1 |
| 16 | On the detection and estimation of long memory in stochastic volatility 显示文摘 | Breidt F J Crato N De Lima P | 1998 | Journal of Econometrics1998，83，： | 1 |
| 17 | Elemental and gamma-ray surveys in the volcanic soils of Ischia Island,Italy 显示文摘 | Frattini P De Vivo B Lima A | 2006 | Geochemistry:Exploration Environment Analysis2006，6，4： | 1 |
| 18 | Toward developing an optimal cooperative search algorithm for multiple unmanned aerial vehicles显示文摘 | DE LIMA P PACK D | 2008 | Collaborative Technologies and Systems2008，3，： | 1 |
| 19 | Single-mask microfabrication of aspherical optics using KOH anisotropic etching of Si显示文摘 | D W de Lima Monteiro O Akhzar-Mehr P M Sarro | 2003 | Opitcal Express2003，11，18： | 1 |
| 20 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员