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	题名	作者	年代	出处	被引量
1	role of microRNAs in the main molecular pathways of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is the most common primary liver malignant neoplasia. HCC is characterized by a poor prognosis. The need to find new molecular markers for its diagnosis and prognosis has led to a progressive increase in the number of scientific studies on this topic. MicroRNAs(miRNAs) are small noncoding RNA that play a role in almost all main cellular pathways. miRNAs are involved in the regulation of expression of the major tumor-related genes in carcinogenesis, acting as oncogenes or tumor suppressor genes. The aim of this review was to identify papers published in 2017 investigating the role of miRNAs in HCC tumorigenesis. miRNAs were classified according to their role in the main molecular pathways involved in HCC tumorigenesis:(1) m TOR;(2) Wnt;(3) JAK/STAT;(4) apoptosis; and(5) MAPK. The role of miRNAs in prognosis/response prediction was taken into consideration. Bearing in mind that the analysis of miRNAs in serum and other body fluids would be crucial for clinical management, the role of circulating miRNAs in HCC patients was also investigated. The most represented mi RNA-regulated pathway in HCC is m TOR, but apoptosis, Wnt, JAK/STAT or MAPK pathways are also influenced by mi RNA expression levels. These miRNAs could thus be used in clinical practice as diagnostic, prognostic or therapeutic targets for HCC treatment.	Francesco Vasuri Michela Visani Giorgia Acquaviva Thomas Brand Michelangelo Fiorentino Annalisa Pession Giovanni Tallini Antonia D’Errico Dario de Biase	2018	World Journal of Gastroenterology2018，24，25：	16
2	Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells ( HL60, NB4 ) Protein kinase modulation and reactive oxygen species generation 显示文摘	Sanehez Y Amran D de Bias E	2009	Bioehem Pharmacol2009，77，3：	1
3	In vitro com- petitive adhesion and production of antagonistic com- pounds by lactic acid bacteria against fish pathogens 显示文摘	Balcazar J L Vendrell D de Bias I	2007	Veterinary Microbiology2007，122，34：	1
4	Molecular diagnosis of carcinomas of the thyroid gland显示文摘	de Biase D Visani M Pession A	2014	Front Biosci2014，6，：	1
5	Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase显示文摘	CAPITANI G DE BIASE D AURIZI C	2003	The EMBO Journal2003，22，16：	1
6	TERT promoter mutations in papillary thyroid microcarcinomas显示文摘	De Biase D Gandolfi G Ragazzi M	2015	Thyroid2015，25，9：	1
7	The response to stationary-phase stress conditions in Escherichia coli:role and regulation of the glutamic acid decarboxylase system显示文摘	DE BIASE D TRAMONTI A BOSSA F et at	1999	Mol Microbiol1999，32，：	1
8	The response to stationary-phase stress conditions in Eschericha coli: role and regulation of the glutamic acid decarboxylase system显示文摘	De Biase D Tramonti A Bossa F	1999	Mol Microbiol1999，32，：	1
9	Isolation and cloning of the gene from Eschericbia coli encoding glutamate decarboxylase 显示文摘	De Biase D Simmaco M Sweeney G	1933	Biotechnol Appl Biochcm1933，18，：	1
10	aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia显示文摘	Grifoni D Garoia F Bellosta P Parisi F De Biase D Collina G	2007	Oncogene2007，26，：	1
11	T( ) repeat in the 3 '-untranslated region of the MT1X gene:a marker with high sensi- tivity and specificity to detect microsatelfite instability in colorectal cancer显示文摘	Morandi L de Biase D Visani M	2012	Int J Colorectal Dis2012，27，5：	1
12	Isolation and cloning of the gene from Escherichia coli encoding glutamate decarboxylase显示文摘	De Biase D Simmaco M Sweeney G	1993	Biotechnol Appl Biochem1993，18，：	1
13	Primary structure and tissue distribution of human 4- aminobutyrate aminotransferase 显示文摘	DE BIASE D BARRA D SIMMACO M	1995	Eur J Biochem1995，227，12：	1
14	Brachial amyotrophic diplegia associated with the al40a superoxide dismutase 1 mutation 显示文摘	Di Vito L de Biase D Pession A	2013	Neurogeneties2013，14，34：	1
15	Crystallization and preliminary X-ray analysis of the beta-isoform of glutamate decarboxylase from Escherichia coli显示文摘	MALASHKEVICH V N DE BIASE D MARKOVIC H Z	1998	Acta Crystallogr D Biol Crystallogr1998，54，5：	1
16	The response to stationary-phase stress conditions in Escherichia coli:role and regulation of the glutamic acid decarboxylase system显示文摘	DE BIASE D TRAMONTI A BOSSA F	1999	Mol Microbiol1999，32，6：	1
17	Glutamate decarboxylase-dependent acid resistance in orally acquired bacteria:function,distribution and biomedical implications of the gad BC operon显示文摘	De Biase D Pennacchietti E	2012	Mol Microbiol2012，86，4：	1
18	Interspecific,intraspecific and interoperonic variability in the 16S rRNA gene of methanogens revealed by length and single strand conformation polymorphonism analysis显示文摘	Daffonchi D De Biase A Rizzi A	1998	FEMS Microbiol Lett1998，164，：	1
19	Chemistry of the inactivation of 4-anfinobutyrate aminotransferase by the antiepileptic drug vigabatrin显示文摘	De Biase D Barra D Bossa F et tl	1991	J Blbl Chem1991，266，20：	1
20	Crystal structure and functional analysis of Escherichia coli glutamate decarboxylase显示文摘	Capitani G De Biase D Aurizi C	2003	The EMBO Journal2003，22，16：	1

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