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| 1 | A novel chemopreventive strategy based on therapeutic microRNAs produced in plants显示文摘 | Sizolwenkosi Mlotshwa Gail J Pruss John L MacArthur Matthew W Endres Celestia Davis Lome J Hofseth Maria Marjorette Pena Vicki Vance | 2015 | Cell Research2015，25，4： | 12 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 4 | Mathematical modeling of the extrusion of 6061/A12O3/20p composite 显示文摘 | CHEN W C DAVIES C H J SAMARASEKERA I V | 1996 | Matallurgical and Materials Transactions1996，，27： | 2 |
| 5 | Spontaneous activity regulates calcium-dependent K^+ current expression in developing ascidian muscle显示文摘 | Dallman J E Davis A K Moody W J | 1998 | J Physiol1998，511，3： | 1 |
| 6 | An electrophoretic karyotype of Neurospora crassa显示文摘 | Orbach M J Vollrath D Davis R W | 1988 | Mol Cell Biol1988，，8： | 1 |
| 7 | Root signals and the regulation of growth and development of plants in drying soil显示文摘 | Davies W J Zhang J | 1991 | Ann Rev Plant physio1991，42，： | 1 |
| 8 | An Unusual form of Carbon显示文摘 | Davis W R Slawson R J Rigby G R | 1953 | Nature1953，171，： | 1 |
| 9 | Long-term carbon dioxide fluxes from a very tall tower in a northern forest:flux measurement method,ology显示文摘 | BERGER B W DAVIS K J YI C | 2001 | Atmos Ocean Technol2001，18，： | 1 |
| 10 | How do chemical signals work in plants that grow in drying soil显示文摘 | Davies W J Tardieu F Trejo C L | 1994 | Plant Physiology1994，104，： | 1 |
| 11 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 12 | Work stress and well-being in the hotel industry显示文摘 | O' Neill J W Davis K | 2011 | International Journal of Hospitality Management2011，30，： | 1 |
| 13 | REM sleep deprivation-induced deficits in the latency-to-peak induction and maintenance of long-term potentiation within the CA1 region of the hippocampus显示文摘 | Christopher J Davis Joseph W Harding John W Wright | | 0，，02： | 1 |
| 14 | The petroleum of Tertiary coal from western Indonesia:Relationship to mire type and sequence stratigraphic setting显示文摘 | Davis R C Noon S W Harrington J | 2007 | International Journal of Coal Geology2007，70，： | 1 |
| 15 | Determinationof the sedimentary microbial biomass by extractible lipidphosphate显示文摘 | White D C Davis W M Nickels J S | 1979 | Oecologia1979，40，1： | 1 |
| 16 | A point and line source model of laser key hole welding显示文摘 | Steen W M Dowden J Davis M | 1988 | Journal of Physics D: Applied Physics1988，21，8： | 1 |
| 17 | Early growth and environmental implication of dietary zinc and copper concentrations and sources of broiler chicks显示文摘 | Dozier W A Davis A J Feeeman M E | 2003 | British Poultry Science2003，44，： | 1 |
| 18 | Laparoscopic dismembered pyeloplasty-the method of choice in the presence of an enlarged renal pelvis and crossing vessels显示文摘 | Turk I A Davis J W Winkelmann B | 2002 | Eur Urol2002，42，： | 1 |
| 19 | Genetics of Parkinsonism:A review显示文摘 | VAUGHAN J R DAVIS M B WOOD N W | 2001 | Annals of Human Genetics2001，65，2： | 1 |
| 20 | Regulation by roots and shoots of water-stressed maize plant显示文摘 | Sharp R E Davies W J | 1989 | Planta1989，147，： | 1 |
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