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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Spontaneous activity regulates calcium-dependent K^+ current expression in developing ascidian muscle显示文摘 | Dallman J E Davis A K Moody W J | 1998 | J Physiol1998，511，3： | 1 |
| 4 | Universal amplification and analysis of pathogen 16S rRNA for classification and identification of mycoplasmalike organisms 显示文摘 | Lee I M Hammond R W Davis R E | 1993 | Phytopathology1993，83，8： | 1 |
| 5 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 6 | Mapping of city lights using DMSP Operational Linesean System data显示文摘 | Elvidge C D Baugh K E Kihn E A Kroehl H W Davis E R | 1997 | Photogrammetrie Engineering and Remote Sensing1997，63，6： | 1 |
| 7 | A numerical investiga- tion of the effects of cas-phase particle formation on silicon film depo- sition from silane显示文摘 | Kremer D M Davis R W Moore E F | 2003 | J Cryst Growth2003，247，333： | 1 |
| 8 | Early growth and environmental implication of dietary zinc and copper concentrations and sources of broiler chicks显示文摘 | Dozier W A Davis A J Feeeman M E | 2003 | British Poultry Science2003，44，： | 1 |
| 9 | Regulation by roots and shoots of water-stressed maize plant显示文摘 | Sharp R E Davies W J | 1989 | Planta1989，147，： | 1 |
| 10 | Project scheduling under resource constraints historical review andcategorization of procedures显示文摘 | Davis E W | 1973 | AIIE Trans1973，5，4： | 1 |
| 11 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 12 | The autonomous underwater glider 'spray' 显示文摘 | SHERMAN J DAVIS R E OWENS W B | 2001 | IEEE Journal of Oceanic Engineering2001，126，4： | 1 |
| 13 | Multi-project scheduling: Cate- gorization of heuristic rules performance 显示文摘 | Ktlrtulus I E W Davis | 1982 | Management Science1982，，2： | 1 |
| 14 | Constraining Hydrological and Cryospberic Mass Flux in Southeastern Alaska Using Space-based Gravity Measurements显示文摘 | Tamisiea M E Leuliette E W Davis J L | 2005 | Geophysical Research Letters2005，32，20： | 1 |
| 15 | Endoscopic partial inferior turbinoplasty显示文摘 | DELDEN M R COOK P R DAVIS W E | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 16 | In - situ X - ray ab- sorption spectroscopy of supported ru catalysts in the a- queous phase显示文摘 | Ketchie W C Maris E P Davis R J | 2007 | Chem Mater2007，19，： | 1 |
| 17 | X-43A flush airdata sensing system flight-test results显示文摘 | Baumann E Pahle J W Davis M C | 2010 | Journal of Spacecraft and Rockets2010，47，1： | 1 |
| 18 | Chitosan in crab shell wastes purifies electroplating wastewater 显示文摘 | Coughin R W Deshaies M R Davis E M | 1990 | Environ Progress1990，9，1： | 1 |
| 19 | Antibodies definemultiple proteins with epitopes exposedon the surface of live Babesia bige mina merozoites显示文摘 | McElwain T F Perryman L E Davis W C | 1987 | Immunol1987，138，7： | 1 |
| 20 | Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase显示文摘 | Parad RB Michele T Allred E Price A Rosenfeld W | 2003 | Pediatrics2003，111，3： | 1 |
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