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| 1 | Role of artificial intelligence in hepatobiliary and pancreatic surgery显示文摘Over the past decade,enhanced preoperative imaging and visualization,improved delineation of the complex anatomical structures of the liver and pancreas,and intra-operative technological advances have helped deliver the liver and pancreatic surgery with increased safety and better postoperative outcomes.Artificial intelligence(AI)has a major role to play in 3D visualization,virtual simulation,augmented reality that helps in the training of surgeons and the future delivery of conventional,laparoscopic,and robotic hepatobiliary and pancreatic(HPB)surgery;artificial neural networks and machine learning has the potential to revolutionize individualized patient care during the preoperative imaging,and postoperative surveillance.In this paper,we reviewed the existing evidence and outlined the potential for applying AI in the perioperative care of patients undergoing HPB surgery. | Hassaan Bari Sharan Wadhwani Bobby V M Dasari | 2021 | World Journal of Gastrointestinal Surgery2021，13，1： | 4 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | Operative management of small bowel Crohn' s disease显示文摘 | Gardiner K R Dasari B V M | 2007 | Surg Clin N Am2007，87，3： | 1 |
| 4 | Human umbilical cord blood stem cells upregulatematrix metalloproteinase-2 in rats after spinal cordinjury 显示文摘 | VEERAVALLI K K DASARI V R TSUNG A J etal | 2009 | Neurobiol Dis2009，36，1： | 1 |
| 5 | Recent advances in designing an effective vaccine to prevent cytomegalovirus-associated clinical diseases 显示文摘 | Dasari V Smith C Khanna R | 2013 | Expert Rev Vaccines2013，12，6： | 1 |
| 6 | Incidental gallbladder cancer diagnosis confers survival advantage irrespective of tumour stage and characteristics显示文摘BACKGROUND Incidental gallbladder cancer(IGBC)represents 50%-60%of gallbladder cancer cases.Data are conflicting on the role of IGBC diagnosis in oncological outcomes.Some studies suggest that IGBC diagnosis does not affect outcomes,while others that overall survival(OS)is longer in these cases compared to non-incidental diagnosis(NIGBC).Furthermore,some studies reported early tumour stages and histopathologic characteristics as possible confounders,while others not.AIM To investigate the role of IGBC diagnosis on patients’overall survival,especially after surgical treatment with curative intent.METHODS Retrospective analysis of all patient referrals with gallbladder cancer between 2008 and 2020 in a tertiary hepatobiliary centre.Statistical comparison of patient and tumour characteristics between IGBC and NIGBC subgroups was performed.Survival analysis for the whole cohort,surgical and non-surgical subgroups was done with the Kaplan-Meier method and the use of log rank test.Risk analysis was performed with univariable and multivariable Cox regression analysis.RESULTS The cohort included 261 patients with gallbladder cancer.65%of cases had NIGBC and 35%had IGBC.A total of 90 patients received surgical treatment(66%of IGBC cases and 19%of NIGBC cases).NIGBC patients had more advanced T stage and required more extensive resections than IGBC ones.OS was longer in patients with IGBC in the whole cohort(29 vs 4 mo,P<0.001),as well as in the non-surgical(14 vs 2 mo,P<0.001)and surgical subgroups(29 vs 16.5 mo,P=0.001).Disease free survival(DFS)after surgery was longer in patients with IGBC(21.5 mo vs 8.5 mo,P=0.007).N stage and resection margin status were identified as independent predictors of OS and DFS.NIGBC diagnosis was identified as an independent predictor of OS.CONCLUSION IGBC diagnosis may confer a survival advantage independently of the pathological stage and tumour characteristics.Prospective studies are required to further investigate this,including detailed pathological analysis and molecular gene expression. | Moath Alarabiyat Syed Soulat Raza John Isaac Darius Mirza Ravi Marudanayagam Keith Roberts Manuel Abradelo David C Bartlett Bobby V Dasari Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastroenterology2022，28，18： | 1 |
| 7 | Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury显示文摘 | Dasari V R Veeravalli K K Tsung A J | 2009 | Neurotrauma2009，26，11： | 1 |
| 8 | Epithelial-mesenchymal transition in lung Cancer:is tobacco the 'smoking Gun'?显示文摘 | DASARI V GALLUP M LEMJABBAR H | 2006 | Am J Respir Cell Mol Biol2006，35，1： | 1 |
| 9 | Axonal remyelination by cord blood stem cells after spinal cord injury显示文摘 | Dasari V R Spomar D G Gondi C S | 2007 | J Neurotrauma2007，24，2： | 1 |
| 10 | Optimization of medium constituents for Cephalosporin C production using response surface methodology and artificial neural networks显示文摘 | DASARI V R R K DONTHIREDDY S R R NIKKU M Y | 2009 | Journal of biochemical technology2009，1，3： | 1 |
| 11 | Optimization of mediumconstituents for cephalosporin C production using responsesurface methodology and artificial neural networks 显示文摘 | Ravi Kumar Dasari V R Reddy Donthireddy S R Yugandhar Nikku M | 2009 | JBiochem Technol2009，1，3： | 1 |
| 12 | Clubbed triazoles:a novel approach to antitubercular drugs 显示文摘 | Shiradkar M Suresh Kumar G V Dasari V | 2007 | European Journal of medicinal chemistry2007，42，6： | 1 |
| 13 | Surgical versus endoscopic treatment of bile duct stones显示文摘 | Dasari B V Tan C J Gurusamy K S | 2013 | Cochrane Database Syst Rev2013，9，9： | 1 |
| 14 | Optimization of the down strain process for high recovery of rhG-CSF from inclusion bodies expressed in Ezcherichia coli显示文摘 | Dasari V K Are R D Joginapally V R | 2008 | Process Bioehem2008，43，： | 1 |
| 15 | Upregulation of PTEN in glioma ceils by cord blood mesenchymal stem cells inhibits mi- gration via downregulation of the PI3K/Akt pathway 显示文摘 | Dasari V R Kaur K Velpula K K | 2010 | PLoS One2010，5，10： | 1 |
| 16 | Implementation of a polygonal al- gorithm for surface-surface intersections 显示文摘 | Roy U Dasari V R | 1998 | Comput- ers & Industrial Engineering1998，34，2： | 1 |
| 17 | Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury显示文摘 | Veeravalli K K Dasari V R Tsung A J | 2009 | Neurobiol Dis2009，36，1： | 1 |
| 18 | Wnt and hedgehog are critical mediators of cigarette smoke-induced lung cancer显示文摘 | Lemjabbar-Alaoui H Dasari V Sidhu S S | 2006 | PLoS ONE2006，1，1： | 1 |
| 19 | Pancreatic exocrine insufficiency after pancreaticoduodenectomy: Current evidence and management显示文摘Pancreaticoduodenectomy(PD)is the commonest procedure performed for pancreatic cancer.Pancreatic exocrine insufficiency(PEI)may be caused or exacerbated by surgery and remains underdiagnosed and undertreated.The aim of this review was to ascertain the incidence of PEI,its consequences and management in the setting of PD for indications other than chronic pancreatitis.A literature search of databases(MEDLINE,EMBASE,Cochrane and Scopus)was carried out with the MeSH terms“pancreatic exocrine insufficiency”and“Pancreaticoduodenectomy”.Studies that analysed PEI and its complications in the setting of PD for malignant and benign disease were included.Studies reporting PEI in the setting of PD for chronic pancreatitis,conference abstracts and reviews were excluded.The incidence of PEI approached 100%following PD in some series.The pre-operative incidence varied depending on the characteristics of the patient cohort and it was higher(46%-93%)in series where pancreatic cancer was the predominant indication for surgery.Variability was also recorded with regards to the method used for the diagnosis and evaluation of pancreatic function and malabsorption.Pancreatic enzyme replacement therapy is the mainstay of the management.PEI is common and remains undertreated after PD.Future studies are required for the identification of a welltolerated,reliable and reproducible diagnostic test in this setting. | Adithya M Pathanki Joseph A Attard Elizabeth Bradley Sarah Powell-Brett Bobby V M Dasari John R Isaac Keith J Roberts Nikolaos A Chatzizacharias | 2020 | World Journal of Gastrointestinal Pathophysiology2020，11，2： | 1 |
| 20 | DNA methylation regulates the expression of Y chromosome specific genes in prostate cancer显示文摘 | Dasari V K Deng D Perinchery G | 2002 | J Urol2002，167，1： | 1 |
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