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| 1 | Prospective randomized controlled trial evaluating cap-assisted colonoscopy vs standard colonoscopy显示文摘AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assisted colonoscopy (CAC) was performed after consent was obtained. For cases randomized to CAC, one of the three sizes of cap was used: D-201-15004 (with a diameter of 15.3 mm), D-201-14304 (14.6 mm) and D-201-12704 (13.0 mm). All of these caps were produced by Olympus Medical Systems, Japan. Independent predictors for faster cecal time and better polyp detection rate were also determined from this study. RESULTS: There were 200 cases in each group. There was no signif icant difference in terms of demographic characteristics between the two groups. CAC, when compared to the SC group, had no signif icant difference in terms of cecal intubation rate (96.0% vs 97.0%, P = 0.40) and time (9.94 ± 7.05 min vs 10.34 ± 6.82 min, P = 0.21), or polyp detection rate (32.8% vs 31.3%, P = 0.75). On the subgroup analysis, there was no significant difference in terms of cecal intubation time by trainees (88.1% vs 84.8%, P = 0.40), ileal intubation rate (82.5% vs 79.0%, P = 0.38) or total colonoscopy time (23.24 ± 13.95 min vs 22.56 ± 9.94 min, P = 0.88). On multivariate analysis, the independent determinants of faster cecal time were consultant-performed procedures (P < 0.001), male patients (P < 0.001), non-usage of hyoscine (P < 0.001) and better bowel preparation (P = 0.01). The determinants of better polyp detection rate were older age (P < 0.001), no history of previous abdominal surgery (P = 0.04), patients not having esophagogastroduodenoscopy in the same setting (P = 0.003), trainee-performed procedures (P = 0.01), usage of hyoscine (P = 0.01) and procedures performed for polyp follow-up (P = 0.01). The limitations of the study were that it was a single-center experience, no blinding was possible, and there were a large number of endoscopists. CONCLUSION: CAC did not signif icantly different from SC in term of cecal intubation time and polyp detection rate. | Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes | 2010 | World Journal of Gastroenterology2010，16，31： | 10 |
| 2 | Acutehemodynamic effects of intravenous silde-nafil citrate in congestive heart failure:comparison of phosphodiesterase type -3and -5 inhibition 显示文摘 | Botha P Parry G Dark JH | 2009 | J Heart LungTransplant2009，287，： | 1 |
| 3 | Conveying Trustworthiness to Online Consumers: Reactions to Consensus, Physical Store Presence, Brand Familiarity, and Generalized Suspicion 显示文摘 | BENEDICKTUS R L BRADY M K DARKE P R | 2010 | Journal of Retailing2010，86，4： | 1 |
| 4 | Simalation of phase change drywalls in a passive solar building显示文摘 | DARK WA K O'CALLAGHAN P W | 2006 | Applied Tliermal Engineering2006，26，89： | 1 |
| 5 | Single-agent pemetrexedfor chemonaive and pretreated patients with malignant pleuralmesothelioma:results of an International Expanded Access Pro-gram显示文摘 | Taylor P Castagneto B Dark G | 2008 | J Thorac Oncol2008，3，7： | 1 |
| 6 | Stakeholder viewpoints in requirements definition: A framework for understanding viewpoint de- velopment approaches显示文摘 | Darke P Shanks G | 1996 | Requirements Engineering1996，1，2： | 1 |
| 7 | Bench -to -bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction -based pathogen detection 显示文摘 | Dark PM Dean P Warhurst G | 2009 | Crit Care2009，13，4： | 1 |
| 8 | Percentage discounts, initial price, and bargain hunting显示文摘 | Darke P R Freedman J L Chaiken S | 1995 | Journal of Applied Psychology1995，80，5： | 1 |
| 9 | Accuracy of LightCycler(R) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review protocol显示文摘 | Dark P Wilson C Blackwood B | 2012 | BMJ Open2012，2，00： | 1 |
| 10 | The Defensive Consumer:Advertising Deception,Defensive Processing,and Distrust显示文摘 | Darke P R Ritchie R J B | 2007 | Journal of Marketing Research2007，44，1： | 1 |
| 11 | Combined molecular gram typing and high resolution melting analysis for rapid iden- tification of a syndromic panel of bacteria responsible for sepsis associated bloodstream infection显示文摘 | OZBAK H DARK P MADDI S | 2012 | Mol Diagn2012，14，2： | 1 |
| 12 | Cardiac measurements on thoracic radiographs of cats显示文摘 | Van den Broek A M Darke P G | 1987 | Journal of the Small Animal Practice1987，28，1： | 1 |
| 13 | Nontinancial motives and bargain hunting显示文摘 | DARKE P R FREEDMAN J L | 1995 | Journal of Applied Psychology1995，25，18： | 1 |
| 14 | Nonfinancial motives and bargain hunting 显示文摘 | Darke P R Freedman J L | 1995 | Journal of Applied Social Psychology1995，25，18： | 1 |
| 15 | Conveying trustworthiness to online consumers: reactions to consensus, physical store presence, brand familiarity, and generalized suspicion 显示文摘 | Benedicktus R L Brady M K Darke P R | 2010 | Journal of Retailing2010，，4： | 1 |
| 16 | Simalation of phase change drywalls in a passive solar building显示文摘 | Dark Wa K O'Callaghan P W | 2006 | Applied Tliermal Engineering2006，26，89： | 1 |
| 17 | Effects of pricing and promotion on consumer perceptions: it depends on how you frame it显示文摘 | Darke P R Chung C | 2005 | Journal of Retailing2005，81，1： | 1 |
| 18 | Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury 显示文摘 | Clark S C Rao J N Flecknell P A Dark J H | 2003 | J Thorac Cardiovasc Surg2003，126，： | 1 |
| 19 | No One Wants to Look Cheap: Trade-offs Between Social Disincentives and the Economic and Psychological Incentives to Redeem Coupons 显示文摘 | ASHWORTH L DARKE P R SCHALLER M | 2005 | Journal of Consumer Psychology2005，15，4： | 1 |
| 20 | Molecular order and structure in enzymeresistant starch retrograded starch 显示文摘 | Cidley M J Cooke D Darke A H Hoffmann R A Russell A L Greenwell P | 1995 | Carbohydrate Polymers1995，28，1： | 1 |
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