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146篇 您的检索式:作者名="DANIELSEN M"
    题名 作者 年代 出处 被引量
1Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase显示文摘包含 methyltransferase 建筑群的象 3 一样的 methyltransferase (METTL3 ) 催化 N6-methyladenosine (m6A ) 形成,一个新奇 epitranscriptomic 标记;然而,这建筑群的性质仍然保持大部分未知。这里,我们报导人的 m6A methyltransferase 建筑群, Wilm 的肿瘤 1 伙伴蛋白质(WTAP ) 和象 14 一样的 methyltransferase (METTL14 ) 的二个新部件。WTAP 与 METTL3 和 METTL14 交往,并且为他们的本地化被要求进在 vivo 与处理因素的 pre-mRNA 并且为 m6A methyltransferase 的催化活动充实的原子点缀。RNA 的多数在 vivo 由 WTAP 和 METTL3 跳了代表包含一致 m6A 主题的 mRNAs。当 WTAP 不在时, METTL3 的 RNA 有约束力的能力强烈被减少,建议 WTAP 可以工作调整到 mRNA 目标的 m6A methyltransferase 建筑群的招募。而且,在有 photoactivatable-ribonucleoside-enhanced crosslinking 和 immunoprecipitation (同等片断) 的联合的 transcriptomic 分析说明那 WTAP 和 METTL3 调整涉及抄写并且 RNA 处理的基因拼接的表示和选择。在 zebrafish 胚胎的调停 Morpholino 的击倒的指向 WTAP 或 METTL3 引起了织物区别缺点并且增加了 apoptosis。这些调查结果提供 WTAP 可以在 m6A methyltransferase 建筑群作为一个规章的子单元工作并且在 RNA 的 epitranscriptomic 规定起一个关键作用的充分证据新陈代谢。Xiao-Li Ping Bao-Fa Sun Lu Wang Wen Xiao Xin Yang Wen-Jia Wang Samir Adhikari Yue Shi Ying Lv Yu-Sheng Chen Xu Zhao Ang Li Ying Yang Ujwal Dahal Xiao-Min Lou Xi Liu Jun Huang Wei-Ping Yuan Xiao-Fan Zhu Tao Cheng Yong-Liang Zhao Xinquan Wang Jannie M Rendtlew Danielsen Feng Liu Yun-Gui Yang 2014Cell Research2014,24,2:244
2FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang 2014Cell Research2014,24,12:109
3Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination显示文摘DNA 双海滨裂缝(DSB ) 是高度细胞毒素的损害并且如果,形成主要威胁到染色体稳定性不适当地修理了。我们和其它以前证明了导致 DSB 的小 RNA (diRNAs ) 的一个班在 DSB 地点附近从序列被生产。DiRNAs 与 Argonaute 被联系(以前) 蛋白质和戏在 DSB 修理的一个重要角色,不过,他们通过行动的机制仍然保持不清楚。这里,我们报导在 DSB 修理的 diRNAs 的角色被限制由相应再结合(HR ) 修理并且它明确地在哺乳动物的房间依靠受动器蛋白质 Ago2。有趣地,我们证明 Ago2 与 Rad51 形成建筑群并且相互作用在与电离对待的房间被提高放射。我们证明在 DSB 地点和 HR 修理的 Rad51 累积取决于催化活动和 Ago2 的小 RNA 有约束力的能力。相反,象装载的 RPA 和 Mre11 一样的 DSB 切除术由 Ago2 或 Dicer 弄空是未受影响的,建议 Ago2 很多半在调停直接工作在 DSB 的 Rad51 累积。一起拿,我们的调查结果建议由 diRNAs 指导了那, Ago2 能在 DSB 支持 Rad51 招募或保留由 HR 便于修理。Min Gao Wei Wei Ming-Ming Li Yong-Sheng Wu Zhaoqing Ba Kang-Xuan Jin Miao-Miao Li You-Qi Liao Samir Adhikari Zechen Chong Ting Zhang Cai-Xia Guo Tie-shah Tang Bing-Tao Zhu Xing-Zhi Xu Niels Mailand Yun-Gui Yang Yijun Qi Jannie M Rendtlew Danielsen 2014Cell Research2014,24,5:3
4Molecular characterization of tet (M) genes in Lactobacillus isolates from different types of fermented dry sausage显示文摘GEVERS D DANIELSEN M HUYS G 2003Applied and Environmental Microbiology2003,69,2:1
5Streptococ-cus thermophilus core genome: comparative genome hybridizationstudy of 47 strains 显示文摘RASMUSSEN T B DANIELSEN M VALINA O 2008Applied and Environmental Microbiology2008,74,15:1
6Changes in body composition,cardiovascular disease risk factors,and eating behavior after an intensive lifestyle intervention with high volume of physical activity in severely obese subjects: a prospective clinical controlled trial显示文摘Danielsen KK Svendsen M Mgehlum S 2013J Obes2013,,32:1
7Short Sale Constraints, Differences of Opinion, and Overvaluation显示文摘BOEHME R D DANIELSEN B R SORESCU S M 2006Journal of Financial and Quantitative Analysis2006,41,2:1
8Why do option introduc- tions depress stock prices? A study of diminishing short sale constraints 显示文摘Danielsen B R Sorescu S M 2001Journal of Financial and Quantitative Analysis2001,36,04:1
9Quantita-tive milk proteomics-host responses to lipopolysaccharide-me-diated inflammation of bovine mammary gland 显示文摘Danielsen M Codrea M C Ingvartsen K L 2010Pro-teomics2010,10,12:1
10Reservoir aspects of Ekofisk subsidence显示文摘Sulak R M Danielsen J 1989JPT1989,41,7:1
11Mutual associations among microstructural, physical and mechanical properties of human cancellous bone显示文摘DING M ODGAARD A DANIELSEN C C 2002J Bone Joint Surg Br2002,84,6:1
12Image cytometry DNA ploidy correlates with histological subtypes in endometrial carcinomas显示文摘Pradhan M Abeler VM Danielsen HE 2006Mod Pathol2006,19,9:1
13Loss of androgen receptor transcriptional activity at the G(1)/S transition 显示文摘Martinez ED Danielsen M 2002J Biol Chem2002,277,29:1
14Short-sale costs, differences of opinion and overvaluation 显示文摘Boehme R D Danielsen B R Sorescu S M 2006Journal of Financial & Quantitative Analysis2006,41,2:1
15Childbearing beyond age40 :pregnancy outcome in 24032 cases 显示文摘GILBERT W M NESBITT T S DANIELSEN B 1999Obstet Gynecol1999,93,:1
16At the heart of REDD+ : a role for local people in monitoring forests? 显示文摘Danielsen F Skutsch M Burgess N D 2011Conservation Letters2011,4,2:1
17DNA damage and eytotoxieity in type Ⅱ lung epithelial (A549) cell cultures after exposure to diesel exhaust and urban street particles 显示文摘Danielsen PH Loft S Mφller P 2008Part Fibre Toxieol2008,5,:1
18Binding of pyrene to aquatic and commercial humic substances: the role of molecular weight and aromaticity显示文摘Chin Y P Aiken G R Danielsen K M 1997Environ Sci Technol1997,31,:1
19Platelet-rich fibrin versus albumin in surgical wound repair:a randomized trial with paired desigu显示文摘DANIELSEN P L AGREN M S JORGENSEN L N 2010Ann Surg2010,251,5:1
20Structural Analysis of Chitosan Mediated DNA Condensation by AFM:Influ- ence of Chitosan Molecular Parameters显示文摘Danielsen S V&nrm K M Stokke B T 0,,03:1
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