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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Confocal laser endomicroscopy for the differential diagnosis of ulcerative colitis and Crohn’s disease: a pilot study显示文摘 | Gian Tontini Jonas Mudter Michael Vieth Raja Atreya Claudia Günther Yurdagül Zopf Dane Wildner Ralf Kiesslich Maurizio Vecchi Markus Neurath Helmut Neumann | 2014 | Endoscopy2014，，： | 2 |
| 3 | 14-3-3 zeta down-regulates p53 in mammary epithelial cells and confers luminal filling显示文摘 | Danes C G Wyszomierski S L Lu J | 2008 | Cancer Research2008，68，6： | 1 |
| 4 | Exploring intuition and its role in managerial decision making显示文摘 | Dane E Pratt M G | 2007 | Academy of manage- ment review2007，32，1： | 1 |
| 5 | Scaling characteristics of the XeF(C-A) excimer laser显示文摘 | Dane C B Hirst G J | 1990 | IEEE Journal of Quantum Electronics1990，26，9： | 1 |
| 6 | Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases 显示文摘 | MINTZER M A DANE E L O'TOOLE G A | 2012 | Mol Pharm2012，9，3： | 1 |
| 7 | An Efficient HILIC separation of 7 phospholipid classes based on a diol column 显示文摘 | Zhu C Dane A Spijksma G | 2012 | J Chromatogr A2012，1220，： | 1 |
| 8 | Optimal temporal interpolation filter for motion-compensated frame rate up conversion 显示文摘 | DANE G NGUYEN T Q | 2006 | IEEE Trans on Image Processing2006，15，4： | 1 |
| 9 | Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herds显示文摘 | Alonso C Dane P G Robert B M | 2014 | Veterinary Research2014，45，： | 1 |
| 10 | Application of genetic algorithms for characterization of thin layered materials by glancing incidence X-ray reflectometry显示文摘 | Dane A D Veldhuis A Boer D K G | 1998 | Physica B: Physics of Condensed Matter1998，253，34： | 1 |
| 11 | Screening properties of human papillomavirus testing for predicting cervical intraepithelial neoplasia in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion smears: a prospective study 显示文摘 | Dane C Batmaz G Dane B | 2009 | Ann Diagn Pathol2009，13，2： | 1 |
| 12 | Deterioration of a wall complex constructed of reinforced earth 显示文摘 | Blight G E Dane M S W | 1989 | Geotechnique1989，39，1： | 1 |
| 13 | On K-medoid Clustering of Large Data Sets with the Aid of a Genetic Algorithm:Background,Feasibility and Comparison显示文摘 | Lucasius C B Dane A D Kateman G | 1993 | Analytica Chimica Acta1993，282，3： | 1 |
| 14 | 2007, Exploring intuition and its role in managerial decision making 显示文摘 | DANE E PRAT1 M G | 2007 | Academy of Management Review2007，，1： | 1 |
| 15 | Exploring intuition and its role in managerial decision making显示文摘 | Dane E and Pratt M G | 2007 | Academy of Management Re- view2007，32，1： | 1 |
| 16 | Linking calling orientations to organizational attachment via organiza- tional instrumentality 显示文摘 | Cardador M T Dane E Pratt M G | 2011 | Journal of Vocational Be- havior2011，79，2： | 1 |
| 17 | Exploring Intuition and Its Role in Managerial Decision Making显示文摘 | Dane E Pratt M G | 2007 | Academy of Management Review2007，32，： | 1 |
| 18 | When should I trust my gut? Linking domain expertise to intuitive decision- making effectiveness显示文摘 | Dane E Rockmann K W and Pratt M G | 2012 | Organizational Behavior and Human Decision Processes2012，119，： | 1 |
| 19 | Screening properties of human papillomavirus testing for predicting cervical intraepithelial neoplasia in atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion smears:a prospective study显示文摘 | Dane C Batmaz G Dane B | | 0，，02： | 1 |
| 20 | Immune thrombocytopenia associated with pulmonary tuberculosis显示文摘 | Ahmet Ursavas Dane Ediger R?dvan Ali Duygu K?prücüoglu Dilek Bah?etepe Güzin Kocamaz Funda Coskun Ercüment Ege | 2010 | Journal of Infection and Chemotherapy2010，，1： | 1 |
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