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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Endoscopy and polyps-diagnostic and therapeutic advances in management显示文摘Despite multiple efforts aimed at early detection through screening, colon cancer remains the third leading cause of cancer-related deaths in the United States, with an estimated 51000 deaths during 2013 alone. The goal remains to identify and remove benign neoplastic polyps prior to becoming invasive cancers. Polypoid lesions of the colon vary widely from hyperplastic, hamartomatous and inflammatory to neoplastic adenomatous growths. Although these lesions are all benign, they are common, with up to one-quarter of patients over 60 years old will develop pre-malignant adenomatous polyps. Colonoscopy is the most effective screening tool to detect polyps and colon cancer, although several studies have demonstrated missed polyp rates from 6%-29%, largely due to variations in polyp size. This number can be as high as 40%, even with advanced (> 1 cm) adenomas. Other factors including sub-optimal bowel preparation, experience of the endoscopist, and patient anatomical variations all affect the detection rate. Additional challenges in decision-making exist when dealing with more advanced, and typically larger, polyps that have traditionally required formal resection. In this brief review, we will explore the recent advances in polyp detection and therapeutic options. | Scott R Steele Eric K Johnson Bradley Champagne Brad Davis Sang Lee David Rivadeneira Howard Ross Dana A Hayden Justin A Maykel | 2013 | World Journal of Gastroenterology2013，19，27： | 16 |
| 3 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 4 | Upwelling in the Taiwan Strait during the summer monsoon detected by satellite and shipboard measurements 显示文摘 | Tang DanLing Dana R K Ni I- Hsun | 2002 | Remote Sensing of Environment2002，83，： | 1 |
| 5 | Exploring the deepest depths:preliminary design of a novel light-tethered hybrid ROV for global science in extreme enviromnents显示文摘 | Andrew D B Dana R Y | 2004 | Marine Technology Society Journal2004，38，2： | 1 |
| 6 | Corneal lymphangiogenesis:implications in immunity显示文摘 | Patel SP Dana R | | 0，，： | 1 |
| 7 | Quality improvement guidelines for percutaneous transhepatic cholangiography and biliary drainage显示文摘 | Dana R Curtis A John F | 2003 | J Vasc Interv Radiol2003，14，92： | 1 |
| 8 | Fraudulent Financial Reporting: Consideration of Industry Traits and Corporate Governance Mechanisms 显示文摘 | Beasley M S Joseph V Carcello Dana R Hemlanson Paul D Lapides | 2000 | Accounting Horizons2000，14，4： | 1 |
| 9 | Instruments and methods for measuring the backward-scattering coefficient of ocean waters 显示文摘 | Robert A Maffione David R Dana | 1997 | Appl Opt1997，36，24： | 1 |
| 10 | The HITRAN 2008 molecular spectroscopic database 显示文摘 | Rothman L S Gordon I E Barbe A ChrisBenner D Bernath P F Birk M Boudon V Brown L R Campargue A Champi-on J P Chance K Coudert L H Dana V Devi V M Fally S Flaud J M Gamache R R Goldman A Jacquemart D Klein er I Lacome N Lafferty W J Mandin J Y Massie S T Mikhailenko S N Miller C E Moazzen A N Naumenko 0 VNikitin A V Orphal J Perevalov V I Perrin A Predoi C A Rinsland C P Rotger M ime kovd M Smith M A H Sung K Tashkun S A Tennyson J Toth R A Vandaele A C Vander A J | 2009 | Journal of Quantitative Spectroscopy Radiative Transfer2009，110，： | 1 |
| 11 | Differential regulation of peroxisome proliferator activated receptor gamma (PPAR-gamma) and PPAR-gamma 2 messenger RNA expression in the early stages of adipogenesis显示文摘 | Saladin R Fajas L Dana S | 1999 | Cell Growth Differ1999，10，： | 1 |
| 12 | Screening for visual impairment in children ages 1-5 years: update for the USPSTF显示文摘 | Chou R Dana T Bougatsos C | 2011 | Pediat- rics2011，127，2： | 1 |
| 13 | Metal contamination o{ home garden soils and cultivat- ed vegetables in the province of Brescia, Italy Implica tions for human exposure显示文摘 | Roberta Ferria Dana Hashim Donald R Smith | 2015 | Science of the Total Envi- ronment2015，，518519： | 1 |
| 14 | Isolation of the Etiologic Agent of Human Granulogytic Ehdichiosis from the White-footed Mouse 显示文摘 | Dana R Carrie BK Sarah EC | 2001 | J Clin Microbiol2001，39，： | 1 |
| 15 | Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis显示文摘 | Saladin R Fajas L Dana S | 1999 | Cell Growth Differ1999，10，1： | 1 |
| 16 | Comeal neovascularization and the utility of topi-cal VEGF inhibition : ranibizumab (Lucentis) vs bevacizuma(Avastin) 显示文摘 | STEVENSON W CHENG SF DASTJERDI MH FERRARI G DANA R | 2012 | Ocul Surf2012，10，2： | 1 |
| 17 | Upwelling in the Taiwan Strait during the summer monsoon detected by satellite and shipboard measurements显示文摘 | Tang D L Kester Dana R Ni I-Hsun | 2002 | Remote Sensing of Environment2002，83，： | 1 |
| 18 | Instruments and methods for measuring the backward-scattering coefficient of ocean waters显示文摘 | Maffione R A Dana D R | 1997 | Proceeding of Applied Optics1997，36，： | 1 |
| 19 | Differential regulation of peroxisome proliferators gamma1 (PPARgamma1) and PPAR-gamma-messenger RNA expression in the early stages of adipogenesis显示文摘 | Saladin R Fajas L Dana S | 1999 | Cell Growth Differ1999，10，： | 1 |
| 20 | Anterior inferior cerebellar artery territory infarcts mechanisms and clincal features显示文摘 | Pierre A Axel R Dana D | 1993 | Arch Neurol1993，50，2： | 1 |
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