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您的检索式：作者名="DAI Linglin"
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| 1 | Effects of Montmorillonite on Pb Accumulation, Oxidative Stress, and DNA Damage in Tilapia (Oreochromis niloticus) Exposed to Dietary Pb显示文摘 | Wei Dai Linglin Fu Huahua Du Huitao Liu Zirong Xu | 2010 | Biological Trace Element Research2010，，1： | 1 |
| 2 | Influence of the Calmodulin Antagonist EBB on Cyclin B1 and Cdc2-p34 in Human Drug-resistant Breast Cancer MCF-7/ADR Cells显示文摘OBJECTIVE To investigate the influence of O-(4-ethoxyl-butyl)- berbamine(EBB)on the expression of cyclin B1 and cdc2-p34 in the human drug-resistant breast cancer MCF-7/ADR cell line. METHODS The MTT assay was used to assess the cytotoxicity of EBB.Different levels of EBB were added to different cell lines at series of time points solely or combined with doxorubicin(DOX) to detect the effect on the expression of cyclinB1 and cdc2-p34 by Western blots.cdc2-p34 tyrosine phosphorylation was detected by immunoprecipitation.In addition,apoptosis and cytoplastic Ca 2+ concentrations were systematically examined by laser scanning confocal microscopy(LSCM). RESULTS EBB showed little inhibitory activity on human umbilical vein endothelial cells(ECV304),whereas EBB inhibited cell growth(IC50 range,4.55~15.74μmol/L)in a variety of sensitive and drug-resistance cell lines.EBB also down-regulated the expression of cyclin B1 and cdc2-p34 in a concentration and time dependent manner,which was an important reason for the G2/M phase arrest.EBB was shown to induce apoptosis of MCF-7/ADR cells while increasing the level of cytoplastic Ca 2+ . CONCLUSION The low cytotoxicity of EBB suggests it may be useful as a rational reversal agent.The effect of EBB on cell cycle arrest and related proteins,apoptosis,and cytoplastic Ca 2+ concentration may be involved in reversing multidrug resistance. | Xu Shi Yanhong Cheng Linglin Zou Dongsheng Xiong Yuan Zhou Ming Yang Dongmei Fan Xiaohua Dai Chunzheng Yang Huifang Zhu | 2008 | Chinese Journal of Clinical Oncology2008，5，2： | 0 |
| 3 | Efficiency and safety of acupuncture for women with premature ovarian insufficiency:study protocol for a randomized controlled trial显示文摘Acupuncture has been widely used as an alternative and complementary therapy for premature ovarian insufficiency(POI)in China.However,research to date has not shown that acupuncture is effective for POI compared with hormone replacement therapy(HRT).We will conduct a randomized,controlled,and outcome assessor-blind trial to evaluate the efficacy and safety of acupuncture on POI.Seventy-six patients with POI will be randomly assigned to two groups.The treatment group will receive twenty-eight one-hour sessions of acupuncture treatments,and the control group will receive 12-week HRT.The whole study will consist of a 12-week treatment plan and a 12-week follow-up session.The primary outcome is measured by changes in serum anti-Müllerian hormone and follicle-stimulating hormone(FSH)levels at weeks 12 and 24.Secondary outcome measures include estradiol,luteinizing hormone(LH),LH/FSH ratio,Kupperman index,and menstrual condition.This trial is expected to clarify whether or not acupuncture is effective and safe for POI compared with HRT. | XU Yani ZHANG Yutong HE Weile DAI Linglin TANG Ding WANG Jialing ZHANG Xufen CHEN Qin CHEN Lifang WANG Zhanglian ZHAN Mingjie | 2023 | Journal of Traditional Chinese Medicine2023，43，6： | 0 |
| 4 | Application of Intravenous Indwelling Needle in Undergraduate's Pharmacology Teaching Experiment显示文摘In this study,an intravenous indwelling needle was placed in the central artery of rabbit ear for collecting blood.The results show that this method greatly improves the success rate of blood sampling and well controls the experimental time.The students'unanimous feedback was that the method is simple and easy to operate,which is of great help to the stability of the experimental results. | Yifei CHEN Jun LU Jingchen WEI Linglin CHEN Liang LU Zhikai DAI Yongwen LI | 2020 | Medicinal Plant2020，11，6： | 0 |
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