|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Pancreaticoduodenectomy with vascular reconstruction for adenocarcinoma of the pancreas with borderline resectability显示文摘AIM:To analyze whether pancreaticoduodenectomy with simultaneous resection of tumor-involved vessels is a safe approach with acceptable patient survival.METHODS:Between January 2001 and March 2012,136 patients received pancreaticoduodenectomy for adenocarcinoma at our hospital.Seventy-eight patients diagnosed with pancreatic head carcinoma were included in this study.Among them,46 patients received standard pancreaticoduodenectomy(group 1)and32 patients received pancreaticoduodenectomy with simultaneous resection of the portal vein or the superior mesenteric vein or artery(group 2)followed by reconstruction.The immediate surgical outcomes and survivals were compared between the groups.Fifty-five patients with unresectable adenocarcinoma of the pancreas without liver metastasis who received only bypassoperations(group 3)were selected for additional survival comparison.RESULTS:The median ages of patients were 67 years(range:37-82 years)in group 1,and 63 years(range:35-86 years)in group 2.All group 2 patients had resection of the portal vein or the superior mesenteric vein and three patients had resection of the superior mesenteric artery.The pancreatic fistula formation rate was21.7%(10/46)in group 1 and 15.6%(5/32)in group2(P=0.662).Two hospital deaths(4.3%)occurred in group 1 and one hospital death(3.1%)occurred in group 2(P=0.641).The one-year,three-year and five-year overall survival rates in group 1 were 71.1%,23.6%and 13.5%,respectively.The corresponding rates in group 2 were 70.6%,33.3%and 22.2%(P=0.815).The one-year survival rate in group 3 was13.8%.Pancreaticoduodenectomy with simultaneous vascular resection was safe for pancreatic head adenocarcinoma.CONCLUSION:The short-term and survival outcomes with simultaneous resection were not compromised when compared with that of standard pancreaticoduodenectomy. | Tan To Cheung Ronnie TP Poon Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai See Ching Chan Sheung Tat Fan Chung Mau Lo | 2014 | World Journal of Gastroenterology2014，20，46： | 8 |
| 3 | Outcome analysis of management of liver trauma: A 10-year experience at a trauma center显示文摘AIM: To review the outcomes of liver trauma in patients with hepatic injuries only and in patients with associated injuries outside the liver.METHODS: Data of liver trauma patients presented to our center from January 2003 to October 2013 were reviewed. The patients were divided into two groups. Group 1 consisted of patients who had hepatic injuries only. Group 2 consisted of patients who also had associated injuries outside the liver.RESULTS: Seven(30.4%) patients in group 1 and 10(28.6%) patients in group 2 received non-operative management; the rest underwent operation. Blunt trauma occurred in 82.8%(48/58) of the patients and penetrative trauma in 17.2%(10/58). A higher injury severity score(ISS) was observed in group 2(median 45 vs 25, P < 0.0001). More patients in group 1 were hemodynamically stable(65.2% vs 37.1%, P = 0.036). Other parameters were comparable between groups. Group 1 had better 30-d survival(91.3% vs 71.4%, P = 0.045). On multivariate analysis using the logistic regression model, ISS was found to be associated with mortality(P = 0.004, hazard ratio = 1.035, 95%CI:CONCLUSION: Liver trauma patients with multiple injuries are relatively unstable on presentation. Despite a higher ISS in group 2, non-operative management was possible for selected patients. Associated injuries outside the liver usually account for morbidity and mortality. | Wong Hoi She Tan To Cheung Wing Chiu Dai Simon HY Tsang Albert CY Chan Daniel KH Tong Gilberto KK Leung Chung Mau Lo | 2016 | World Journal of Hepatology2016，8，15： | 3 |
| 4 | Survival analysis of breast cancer liver metastasis treated by hepatectomy: A propensity score analysis for Chinese women in Hong Kong显示文摘Background: Survival of patients with breast cancer liver metastasis is very poor. This study aimed to analyze the survival outcome of hepatectomy for this patient population. Methods: From January 1995 to December 2014, 2522 patients with liver cancer received hepatectomy at our hospital. Twenty-one of them, all female, received the operation for breast cancer liver metastasis. Performance was compared with patients with colorectal liver metastasis treated with hepatectomy after propensity score analysis in a ratio of 1:3. Results: Twenty-one patients received hepatectomy for breast cancer. After propensity score matching, 63 patients who had hepatectomy for colorectal cancer were selected for comparison. There was no significant difference in immediate or short-term outcomes between the two groups of patients in terms of operative time, blood loss and surgical morbidities. All patients with breast cancer had R0 resection. No hospital death occurred. After hepatectomy, the 1-, 3- and 5-year overall survival rates were 100.0%, 58.9% and 58.9% respectively in patients with breast cancer. The 1-, 3- and 5-year overall survival rates were 95.0%, 57.2% and 39.7% respectively in patients with colorectal cancer (P = 0.572). On multivariate analysis, triple negative status was the only independent poor prognostic factor in breast cancer liver metastasis (OR = 6.411;95% CI: 1.351–30.435;P = 0.019). Conclusions: Hepatectomy is a safe and effective way of treating breast cancer liver metastasis at experienced centers where multidisciplinary adjuvant treatments are available. It can be considered more frequently as part of the multidisciplinary care for this patient population. | Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Wing Chiu Dai Thomas CC Yau Ava Kwong Chung Mau Lo | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，5： | 3 |
| 5 | The impact of family history of hepatocellular carcinoma on its patients' survival显示文摘BACKGROUND:Family history of hepatocellular carcinoma(HCC) has been identified as a risk factor for the development of the disease.The aim of this study is to evaluate the impact of such a history on HCC patients' survival.METHODS:Data of all HCC patients(n=4532) managed at our center from 1989 to 2008 were prospectively collected.The patients were quizzed on their various characteristics including family HCC history.RESULTS:Totally 475(10.48%) patients had a family history of HCC.They presented the disease at a significantly earlier age(median 53 vs 59 years,P<0.0001) and at an earlier stage(the United Network for Organ Sharing staging system).They had significantly better liver function in terms of ChildPugh classification and serum albumin and bilirubin levels.Significantly more of them presented the disease without symptoms(44.0% vs 29.4%,P<0.0001).They also had significantly better overall survival under these specifications:patients in the whole study cohort,patients who had minor hepatectomy,patients with stage I disease,patients with stage II disease,and patients with stage III disease.CONCLUSIONS:Contrary to what is generally believed,we found in this study cohort that patients with a family history of HCC had better overall survival than those without such a history.We believe this was in part due to earlier diagnosis of the disease and better liver function in this group of patients.However,the effects of genetic factors on the risk of HCC cannot be overlooked and are yet to be identified. | Wing Chiu Dai Sheung Tat Fan Tan To Cheung Kenneth SH Chok Albert CY Chan Simon HY Tsang Ronnie TP Poon Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 2 |
| 6 | Hepatopancreatoduodenectomy for advanced hepatobiliary malignancies: a single-center experience显示文摘BACKGROUND:Hepatopancreatoduodenectomy is a complicated and challenging procedure but necessary for curative resection for advanced hepatobiliary malignancies.This retrospective study was to examine the safety and survival outcomes of hepatopancreatoduodenectomy in our center.METHODS:Prospectively collected data of 12 patients who underwent hepatopancreatoduodenectomy for advanced hepatobiliary malignancies in our hospital from January 1998 to December 2014 were analyzed.The primary endpoints are treatment-related morbidity and mortality and the secondary endpoints are overall survival and disease-free survival.RESULTS:Curative resection was achieved in 11(91.7%) patients.Complications developed in 10(83.3%) patients.Three hospital deaths resulted from multiorgan failure secondary to postoperative pancreatic fistula or hepaticojejunostomy leakage.Six of the nine remaining patients had disease recurrence.The nine patients had a median survival of 39.8(5.3-151.8) months.The 1-,3- and 5-year overall survival rates were 66.7%,55.6% and 27.8%,respectively.The corresponding disease-free survival rates were 55.6%,44.4% and 29.6%,respectively.CONCLUSIONS:Morbidity and mortality after hepatopancreatoduodenectomy were significant.With R0 resection,the 5-year overall survival and disease-free survival rates were 27.8% and 29.6%,respectively. | Wing Chiu Dai Kenneth SH Chok Tan To Cheung Albert CY Chan See Ching Chan Chung Mau Lo | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，4： | 2 |
| 7 | Inhibition of colon tumur progression and angiogenesis by the INK4a/Arf locus显示文摘 | Gibson SL Dai CY Lee HW | 2003 | Cancer Res2003，63，4： | 1 |
| 8 | Inhibition of hypaxia inducible factor 1α causes oxygen-independent cytotoxicity and induces p53 in-dependent apoptosis in gliohlastoma cells显示文摘 | Dai S Huang ML Hsu CY | 2003 | Int J Radiat Oncol Biol Phys2003，55，4： | 1 |
| 9 | Glyceroglycolipids from Serratula strangulata显示文摘 | Zhu QX Zhao CY | 2000 | Phtochem2000，58，： | 1 |
| 10 | Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer显示文摘 | Sasaki H Yu CY Dai M | 2003 | Breast Cancer Res Treat2003，77，3： | 1 |
| 11 | Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus 显示文摘 | GIBSON SL DAI CY LEE HW | 2003 | Cancer Res2003，63，4： | 1 |
| 12 | High versus standard doses interferon-alpha in the treatment of naive chronic hepatitis C patients in Taiwan:a 10-year cohort study显示文摘 | Yu ML Dai CY Chen SC | | 0，，： | 1 |
| 13 | Antinuclear antibody is associated with a more advanced fibrosis and lower RNA levels ofhepatitis C virus in patients with chronic hepatitis C 显示文摘 | Hsieh MY Dai CY Lee LP | 2008 | J Clin Pathol2008，61，1： | 1 |
| 14 | Inhibition of hypoxia inducible factor 1 alpha causes oxygen-independent cytotoxicity and induce p53 independent apoptosis in glioblastoma cells显示文摘 | Dai S Huang ML Hsu CY | 2003 | Int J Radiat Onco Biol Phys2003，55，4： | 1 |
| 15 | Rapid virological responseand treatment duration for chronic hepatitis C genotype 1 patients: a randomized trial 显示文摘 | YuML Dai CY Huang JF | 2008 | Hepatology2008，47，6： | 1 |
| 16 | Diversity of root-associated fungal endophytes in Rhododendron fortunei in subtropical forests of China显示文摘 | Zhang CY Yin LJ Dai SL | 2009 | Mycorrhiza2009，19，： | 1 |
| 17 | Inhibition of colon tumor progression and angiogenesis by the IN K4a0Arf locus显示文摘 | GIBSON S L DAI CY LEE H W | 2003 | Cancer Res2003，63，4： | 1 |
| 18 | Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus 显示文摘 | Gibson SL Dai CY Lee HW | 2003 | Cancer Res2003，63，4： | 1 |
| 19 | Effectiveness of a pilot pro- ject of discharge planning in Taiwan 显示文摘 | Dai YT Chang Y Hsieh CY | 2003 | Research in nursing & health2003，26，1： | 1 |
| 20 | Early mortality in Taiwanese lamivudine-treated patients with chronic hepatitis B-related decompensation: Evaluation of the model for end-stage liver disease and index scoring systems as prognostic predictors显示文摘 | Dai CY Chuang WL Hou NJ | 2006 | Clin Ther2006，28，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员