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| 1 | Is diabetes a causal agent for colorectal cancer? Pathophysiological and molecular mechanisms显示文摘The possible relationship between diabetes mellitus (DM) and colorectal cancer (CRC), concerning pathophysiological and molecular mechanisms is highlighted in this review. The most recent and complete articles and developments in this particular field were thoroughly reviewed. Common risk factors, such as obesity, sedentary lifestyle, and Western diet between DM and CRC, led to the theory that DM might be a causal agent for CRC development. Various studies have connected type 2 DM and CRC, either proximal or distal, in both sexes. Additionally, chronic insulin treatment has been linked with increased colorectal tumor risk among type 2 diabetic patients. Interestingly, elevated hemoglobin A1c has been proven to be an independent predictor of aggressive clinical behavior in CRC patients. These mechanisms include the insulin-like growth factor-hyperinsulinemia theory and the participation of oncogenic intracellular signaling pathways. Furthermore, it has been proposed that Cox-2 inhibitors might have a role in decreasing the incidence of CRC. Finally, the use of statins to reduce the risk for colon cancer in patients with diabetes has remained controversial. Diabetic patients over 50 should receive counseling regarding their elevated risk for CRC, and screening colonoscopy should be recommended before initiating insulin therapy. However, there are no current guidelines, and this strategy is not yet applicable to some countries, as the corresponding risk would not allow screening colonoscopy to be adopted. There is strong evidence to indicate that DM is a causal agent for CRC development. This conclusion provides new impetus for re-evaluating CRC screening worldwide. | Olga Giouleme Michael D Diamantidis Marios G Katsaros | 2011 | World Journal of Gastroenterology2011，17，4： | 15 |
| 2 | Primary gastric non-Hodgkin lymphomas:Recent advances regarding disease pathogenesis and treatment显示文摘Primary gastric lymphomas(PGLs)are distinct lymphoproliferative neoplasms described as heterogeneous entities clinically and molecularly.Their main histological types are diffuse large B-cell lymphoma(DLBCL)or mucosaassociated lymphoma tissue.PGL has been one of the main fields of clinical research of our group in recent years.Although gastric DLBCLs are frequent,sufficient data to guide optimal care are scarce.Until today,a multidisciplinary approach has been applied,including chemotherapy,surgery,radiotherapy or a combination of these treatments.In this minireview article,we provide an overview of the clinical manifestations,diagnosis and staging of these diseases,along with their molecular pathogenesis and the most important related clinical published series.We then discuss the scientific gaps,perils and pitfalls that exist regarding the aforementioned studies,in parallel with the unmet need for future research and comment on the proper methodology for such retrospective studies.Aiming to fill this gap,we retrospectively evaluated the trends in clinical presentation,management and outcome among 165 patients with DLBCL PGL who were seen in our institutions in 1980-2014.The study cohort was divided into two subgroups,comparing the main 2 therapeutic options[cyclophosphamide doxorubicin vincristine prednisone(CHOP)vs rituximab-CHOP(R-CHOP)].A better outcome with immunochemotherapy(R-CHOP)was observed.In the next 2 mo,we will present the update of our study with the same basic conclusion. | Michael D Diamantidis Maria Papaioannou Evdoxia Hatjiharissi | 2021 | World Journal of Gastroenterology2021，27，35： | 6 |
| 3 | Corynebacterium jeikeium bacteremia in a hemodialyzedpatient显示文摘 | lfantidou A M Diamantidis M D Tseliki G | 2010 | Int J Infect Dis2010，14，3： | 1 |
| 4 | Physiological and biological patterns of a highland and a coastal population of the European cherry fruit fly during diapause 显示文摘 | Papanastasiou SA Nestel D Diamantidis AD | 2011 | Journal of Insect Physiology2011，57，1： | 1 |
| 5 | IT/IS Implementation Risks and Their Impact on Finn Performance 显示文摘 | PRODROMOS D CHATZOGLOU ANASTASIOS D DIAMANTIDIS | 2009 | International Journal of Information Management2009，29，2： | 1 |
| 6 | Safety of Long Railway Tunnels 显示文摘 | DIAMANTIDIS D ZUCCARELLI F WESTHAUSER A | 2000 | Reliability Engi- neering and System Safety2000，67，2： | 1 |
| 7 | Effect of calcium additives on physicoehemieal aspects of cell wall pe- ctin and sensory attributes of canned peach(Prunus persiea (L) Batseh cv Andross)显示文摘 | Manganaris G A Vasilakakis P M Diamantidis D | 2005 | Journal of the Science of Food and Agrieuhure2005，85，10： | 1 |
| 8 | Copper levels in patients with hematological malignancies 显示文摘 | Kaiafa G D Saouli Z Diamantidis M D | 2012 | Eur J Intern Med2012，23，8： | 1 |
| 9 | Corynebacterium jeikeium bacteremia in a hemodialyzed patient 显示文摘 | Athina M Ifantidou Michael D Diamantidis Georgia Tseliki | 2010 | International Journal of Infectious Diseases2010，14，： | 1 |
| 10 | On the Reliability of the Creep Coefficient of Structural Concrete显示文摘 | Diamantidis D Madsen H O Rackwitz R | 1983 | Material and Structure1983，17，3： | 1 |
| 11 | Safety of long railway tunnels显示文摘 | D Diamantidis F Zuccarelli A Westhasuer | 2000 | Reliability Engineering and System safety2000，67，： | 1 |
| 12 | Safety of long railway tunnels 显示文摘 | Diamantidis D Zuccarelli F Westhauser A | 2000 | Reliability Engineering and System Safety2000，，67： | 1 |
| 13 | IT/IS Implementation Risks and Their Impact on Firm Performanee显示文摘 | Chatzoglou P D A D Diamantidis | 2009 | International Journal of Information Management2009，29，2： | 1 |
| 14 | Unsupervised Stratification of Cross-Validation for Accuracy Estimation显示文摘 | Diamantidis N A Karlis D Giakoumakis E A | 2000 | Artificial Intelligenee2000，116，： | 1 |
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