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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 3 | An Ordination of the Upland Forest Communities of Southern Wisconsin 显示文摘 | Bray R Curtis T | 1957 | Ecology Monogr1957，27，： | 1 |
| 4 | Determination of Mariners' Reaction Times显示文摘 | | 1980 | Journal of Navigation1980，31，： | 1 |
| 5 | Relationship between diurnal blood ressure, renal hemodynamic function, and the rennin angiotensin sys2tem in type 1 diabetes 显示文摘 | Miller J A Curtis J R Schett E B | 2003 | Diabetes2003，52，7： | 1 |
| 6 | Effects of NO modulation on cardiac arrhythmias in the rat isolated heart显示文摘 | Pabla R Curtis MJ | 1995 | Circ Res1995，77，5： | 1 |
| 7 | Diffusion flame synthesis of single-walled carbon nanotubes显示文摘 | VANDER WAL R L TICICH T M CURTIS V E | 2000 | Chem Phys Lett2000，323，： | 1 |
| 8 | Axotomy upregulates the anterograde transport and expression of brain-derived neurotrophic factor by sensory neuron显示文摘 | Tonra J R Curtis R Wong V | 1998 | J Neurosci1998，18，11： | 1 |
| 9 | Multiple primary breast andthyroid cancer 显示文摘 | Ron E Curtis R Hoffman DA | 1984 | Br J Cancer1984，49，1： | 1 |
| 10 | Fatigue testing of multiangle laminates of CF/PEEK 显示文摘 | Curtis J M Moore D R | 1988 | Composites1988，19，6： | 1 |
| 11 | GAP- 43 immunoreactivity is widespread in the autonomic neurons and sensory neurons of the rat显示文摘 | Stewart HJ Cowen T Curtis R | 1992 | Neuroscience1992，47，3： | 1 |
| 12 | Faster and Easier Radiochemical Purity Testing forSodium Iothalamate显示文摘 | Curtis R B Joanne E C Thomas J H | 1997 | Nucl Med Biol1997，24，： | 1 |
| 13 | Water uptake and strength characteristics of a nanofilled resin based composite显示文摘 | CURTIS A R SHORTALL A C MARQUIS P M | 2008 | J Dent2008，36，3： | 1 |
| 14 | Design, performance, and applications of a coherent ultra wide-band random noise radar 显示文摘 | Narayanan R M Xu Y Hoffmeyer P D and Curtis J O | 1998 | Optical Engineering1998，37，6： | 1 |
| 15 | Quality improvement guidelines for percutaneous transhepatic cholangiography and biliary drainage显示文摘 | Dana R Curtis A John F | 2003 | J Vasc Interv Radiol2003，14，92： | 1 |
| 16 | An ecoregion approach to mercury bioaccumulation by fish in reservoirs 显示文摘 | Allen-Gil S M Gilroy D J Curtis L R | 1995 | Archives of Environmental Contamination and Toxicology1995，28，1： | 1 |
| 17 | β-1,3-glucanase activity of two saprophytic yeasts and possible mode of action as biocontrol agents against postharvest diseases显示文摘 | CASTORIA R DE CURTIS F LIMA G | | 0，，： | 1 |
| 18 | Extensive transmission of Mycobacterium tuberculosis from a child显示文摘 | Curtis AB Ridzon R Vogel R | 1999 | N Engl J Med1999，341，20： | 1 |
| 19 | Cognitive-behavioural stress management enhances adjustment in women with breast caneer显示文摘 | Groarke A Curtis R Kerin M | 2013 | Br J Health Psyehol2013，18，3： | 1 |
| 20 | Kinetics of nitrogen uptake by Populus tremuloides in relation to atmospheric CO2 and soil nitrogen availability显示文摘 | Rothstein D E Zak D R Pregitzer K S Curtis P S | 2000 | Tree Physiology2000，20，4： | 1 |
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