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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | 蛋白酶和木聚糖酶对育肥猪的生长性能、营养消化率以及粪便气味的影响显示文摘菜籽粕(RSM)和小麦干酒糟及其可溶物(DDGS)作为副产物可应用到猪的日粮中。然而,与小麦和豆粕型日粮相比,RSM和DDGS中含有较高的非淀粉多糖(NSP),其可限制猪对日粮的有效利用。采用2×2因素试验设计研究生长育肥猪饲粮中添加木聚糖酶(0和200mg·kg-1)和蛋白酶(0和200mg·kg-1)对其生长性能、胴体品质、表观回肠消化率、全消化道养分消化率及粪便气体排放的影响及两种酶之间的相互作用。试验1,对猪的生长性能进行评估。将体重为34.2±2.1kg的育肥猪128头随机分配到4个处理组:以DDGS(300g·kg-1)和RSM(210g·kg-1)的基础日粮;基础日粮中添加蛋白酶200mg·kg-1;基础日粮中添加木聚糖酶200mg·kg-1;基础日粮中添加蛋白酶200mg·kg-1和木聚糖酶200mg·k-1。试验1中,在生长育肥-出栏期间(0~出栏),日粮中添加蛋白酶的试验猪较不添加蛋白酶的试验猪相比具有较低的平均日增重(ADG)(P〈0.001)。生长阶段(0—28d),蛋白酶和木聚糖酶对猪的日均采食量(ADFI,P〈0.01)和体重(BW,P〈0.01)的影响存在相互作用。在育肥阶段(28d~出栏),日粮中添加蛋白酶和木聚糖酶的试验猪与仅添加一种没酶的试验猪相比具有较低的ADFI和BW。然而,蛋白酶和木聚糖酶的相互作用在生长期间(0~28d)内并不显著。试验2,选择体重78±2.3kg公猪24只,将其置于代谢笼中进行代谢试验,试验期间按照试验l中的日粮进行饲喂。木聚糖酶和蛋白酶对总能(GE)中的AID存在相互作用(P〈0.05)。与对照组相比,饲粮中添加蛋白酶可以增加GE中的AID,但饲粮中添加两种酶时可降低GE中的AID。饲粮中添加木聚糖酶交不添加木聚糖组相比,猪粪便的臭气排放量降低(598和1306OuE/m3;P〈0.05)。研究表明,蛋白酶可提高GE的AID;木聚糖酶可以减少粪便异味的排放,然而当生长猪育肥以RSM和DDGS为基础饲粮时,两种酶均不能提高其生长性能。 | O'Shea C J Mc Alpine P O Solan P Curran T Varley P F Walsh A M Doherty J V O | 2014 | 饲料博览2014，0，10： | 4 |
| 3 | Endothelin-1 decreases posteapillary fluid efflux via prostacyclin release显示文摘 | Vietorino G P Chong T J Curran B | 2004 | Surgery2004，136，2： | 1 |
| 4 | Mechanism of Hydrogen-Transfer Process to Coal and Coal Extract显示文摘 | Struck R T Everett Gorin | 1967 | Ind Eng Chem Proc Des Dev1967，6，2： | 1 |
| 5 | LIBERTY Modeling the Effects of Leaf Biochemical Concentration on Reflectance Spectra显示文摘 | Dawson T P Curran P J Plummer S E | 1998 | Remote Sensing of Environment1998，65，1： | 1 |
| 6 | JERS- 1/SAR backscatter and its relationship with biomass of regenerating forests显示文摘 | KUPLICH T M SALVATORI V CURRAN P J | 2000 | International Journal of Remote Sensing2000，21，12： | 1 |
| 7 | A new technique for interpreting the reflectance red-edge position显示文摘 | Dawson T P Curran P J | 1998 | International Journal of Remote Sensing1998，19，： | 1 |
| 8 | Odour and ammoniaemissions from intensive poultry units in Ireland显示文摘 | Hayes E T Curran T P Dodd V A | 2006 | BioresourceTechnology2006，97，7： | 1 |
| 9 | The influence of diet crude protein level on odour and ammonia emissions from finishing pig houses显示文摘 | Hayes E T Leek A B G Curran T P | 2004 | Bioresource Technology2004，91，3： | 1 |
| 10 | A new technique for interpolating the reflectance red edge position显示文摘 | Dawson T P Curran P J | 1998 | International Journal of Remote Sensing1998，19，11： | 1 |
| 11 | LIBERTY-modeling the effects of leaf biochemical concentration on reflectance spectral显示文摘 | Dawson T P Curran P J Plummer S E | 1998 | Remote Sensing of Environment1998，65，1： | 1 |
| 12 | Biofihration of n-butyric Acid for the Control of Odour显示文摘 | Sheridan B A Curran T P Dodd V A | 2003 | Bioresour Technol2003，89，2： | 1 |
| 13 | Biofiltration of n-butyric acid for the control of odour 显示文摘 | Sheridan B A Curran T P Dodd V A | 2003 | Bioresour Technol2003，89，： | 1 |
| 14 | A new technique for interpolating the reflectance red edge position显示文摘 | Dawson T P Curran P J | 1998 | International Journal of Remote Sensing1998，19，11： | 1 |
| 15 | Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis显示文摘 | Zhang Wei Curran D P Christine H T C | 2002 | Tetrahedron2002，58，20： | 1 |
| 16 | Relating SARimage texture to the biomass of regenerating tropical forests显示文摘 | KUPLICH T M CURRAN P J ATKINSON P M | 2005 | International Journal of Remote Sensing2005，26，21： | 1 |
| 17 | Transdermal granisetron 显示文摘 | Duggan S T Curran M P | 2009 | Drugs2009，69，18： | 1 |
| 18 | A new technique for interpolating the reflectance red edge position显示文摘 | Dawson T P Curran P J | 1998 | International Journal of Remote Sensing1998，19，11： | 1 |
| 19 | Biofiltration of n- butyric acid for the control of odour显示文摘 | Sheridan B A Curran T P Dodd V A | 2003 | Bioresource Tech- nology2003，89，： | 1 |
| 20 | Technical note A new technique for interpolating the reflectance red edge position显示文摘 | DAWSON T CURRAN P | 1998 | International Journal of Remote Sensing1998，19，11： | 1 |
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