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3篇 您的检索式:作者名="Crystal Lewis"
    题名 作者 年代 出处 被引量
1Multi-temporal MODIS–Landsat data fusion for relative radiometric normalization, gap filling, and prediction of Landsat data显示文摘David P. Roy Junchang Ju Philip Lewis Crystal Schaaf Feng Gao Matt Hansen Erik Lindquist 2008Remote Sensing of Environment2008,,6:1
2Quality of Life and Exercise Performance in Patients in Sinus Rhythm Versus Persistent Atrial Fibrillation显示文摘Steven N. Singh X. Charlene Tang Bramah N. Singh Paul Dorian Domenic J. Reda Crystal L. Harris Ross D. Fletcher Satish C. Sharma J. Edwin Atwood Alan K. Jacobson H. Daniel Lewis Becky Lopez Dennis W. Raisch Michael D. Ezekowitz 2006Journal of the American College of Cardiology2006,,4:1
3IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling显示文摘Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6 prevents the development of Th2-driven diseases remains unknown. Using a model of house dust mite (HDM)-induced Th2 cell differentiation and allergic airway inflammation, we showed that IL-6 signaling in allergen-specific T cells was required to prevent Th2 cell differentiation and the subsequent IgE response and allergic inflammation. Th2 cell lineage commitment required strong sustained IL-2 signaling. We found that IL-6 turned off IL-2 signaling during early T-cell activation and thus inhibited Th2 priming. Mechanistically, IL-6-driven inhibition of IL-2 signaling in responding T cells was mediated by upregulation of Suppressor Of Cytokine Signaling 3 (SOCS3). This mechanism could be mimicked by pharmacological Janus Kinase-1 (JAK1) inhibition. Collectively, our results identify an unrecognized mechanism that prevents the development of unwanted Th2 cell responses and associated diseases and outline potential preventive interventions.Holly Bachus Erin McLaughlin Crystal Lewis Amber M.Papillion Etty N.Benveniste Dave Durell Hill Alexander F.Rosenberg AndréBallesteros-Tato Beatriz León 2023Cellular & Molecular Immunology2023,20,6:0
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