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| 1 | Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve defects显示文摘Nerve regeneration after delayed nerve repair is often unsuccessful. Indeed, the expression of genes associated with regeneration, including neurotrophic and gliotrophic factors, is drastically reduced in the distal stump of chronically transected nerves; moreover, Schwann cells undergo atrophy, losing their ability to sustain regeneration. In the present study, to provide a three-dimensional environment and trophic factors supporting Schwann cell activity and axon re-growth, we combined the use of an effective conduit(a chitosan tube) with a promising intraluminal structure(fresh longitudinal skeletal muscle fibers). This enriched conduit was used to repair a 10-mm rat median nerve gap after 3-month delay and functional and morphometrical analyses were performed 4 months after nerve reconstruction. Our data show that the enriched chitosan conduit is as effective as the hollow chitosan conduit in promoting nerve regeneration,and its efficacy is not statistically different from the autograft, considered the 'gold standard' technique for nerve reconstruction. Since hollow tubes not always lead to good results after long defects(> 20 mm), we believe that the conduit enriched with fresh muscle fibers could be a promising strategy to repair longer gaps, as muscle fibers create a favorable three-dimensional environment and release trophic factors. All procedures were approved by the Bioethical Committee of the University of Torino and by the Italian Ministry of Health(approval number: 864/2016/PR) on September 14, 2016. | AlessANDro Crosio Benedetta Elena Fornasari Giovanna Gambarotta Stefano Geuna Stefania Raimondo Bruno Battiston Pierluigi Tos Giulia Ronchi | 2019 | Neural Regeneration Research2019，14，6： | 2 |
| 2 | Volcanic quartz growth zoning identified by cathodoluminescence and EPMA studies 显示文摘 | Ruffini R Borghi A Crosio R | 2002 | Microchemist Acta2002，139，： | 1 |
| 3 | Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC 12 cells显示文摘 | Hans A Syan S Crosio C | 2001 | Journal of Biological Chemistry2001，276，10： | 1 |
| 4 | A fimctional role for some fugu introns larger than the typical short ones: the example of the gene coding for ribosomal protein $7 and snoRNAUI7显示文摘 | Cencconi F Crosio C Mariottini P | 1996 | Necl Acid Res1996，24，16： | 1 |
| 5 | Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons显示文摘 | Crosio C Heitz E Allis CD | 2003 | J Cell Sci2003，116，： | 1 |
| 6 | Borna disease virus persistent in-fection activates mitogen-activated protein kinase and blocks neuronaldifferentiation of PC12 cells显示文摘 | Hans A Syan S Crosio C | 2001 | J Biol Chem2001，276，10： | 1 |
| 7 | Crystal Packing in six crystal forms of pancreatic ribonuclease显示文摘 | Crosio MP Janin J Jullien M | 1992 | J Mol Boil1992，228，： | 1 |
| 8 | Differential functions of the Aurora-B and Aurora-C kinases in mammalian spermatogenesis显示文摘 | Kimmins S Crosio C Kotaja N | 2007 | Mol Endocrinol2007，21，3： | 1 |
| 9 | La protein has a positive effect on the translation of TOP mRNAs in vivo 显示文摘 | Crosio C Boyl P P Amaldi F | 2000 | Nucleic Acids Res2000，28，15： | 1 |
| 10 | Borna disease virus persistent infection activates mitogen-activated protein kinase and blocks neuronal differentiation of PC12 cells 显示文摘 | AYMERIC HANS SYLVIE SYAN CLAUDIA CROSIO | 2001 | J Biolog Chem2001，276，： | 1 |
| 11 | Mitotic phosphorylation of histone H3 : spatio - temporal regulation by mammalian Aurora kinases 显示文摘 | Crosio C Fimia GM Loury R | 2002 | Mol Cell Biol2002，7，1： | 1 |
| 12 | Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian aurora kinases显示文摘 | Crosio C Fimia GM Loury R | 2002 | Mol Cell Biol2002，22，： | 1 |
| 13 | Apoptotic mechanisms in mutant LRRK2-mediated cell death显示文摘 | Iaccarino C Crosio C Vitale C | | 0，，11： | 1 |
| 14 | Chrmnatin remodeling and neuronal response:multiple signaling pathways induce specific histone H3 modifications and early gene expression in hipp- ocampal neurons 显示文摘 | Crosio C Heitz E Allis CD | 2003 | J Cell Sci2003，116，24： | 1 |
| 15 | La protein has a positive effect on the translation of TOP mRNA in VIVO显示文摘 | CROSIO C BOYL P P AMALDI F | 2000 | Nucleic Acids Res2000，28，15： | 1 |
| 16 | La protein has a positive effect on the translation of TOP mRNAs in vivo显示文摘 | Crosio C Boyl PP Loreni F | 2000 | Nucleic Acids Res2000，28，15： | 1 |
| 17 | Apoptotic mechanisms in mutant LRRK2-mediated cell death显示文摘 | Iaccarino C Crosio C Vitale C | 2007 | Hum Mol Genet2007，16，11： | 1 |
| 18 | Painful scar neuropathy:principles of diagnosis and treatment显示文摘Nerve-tissue interactions are critical.Peripheral nerve injuries may involve intraneural and extraneural scar formation and affect nerve gliding planes,sometimes leading to complex clinical presentations.All of these pathological entities involve pain as the main clinical symptom and can be subsumed under the term“painful scar neuropathy”.The authors review the literature on treatment approaches to peripheral nerve scar neuropathy and the outcomes of neurolysis-associated procedures and propose a simple classification and a therapeutic approach to scar neuropathy.The search retrieved twenty-one papers,twenty of which reported pain reduction or resolution with various techniques.There is no consensus on the best therapeutic approach to neuropathic pain due to scar tethering.Most authors report good or excellent results with different techniques,from nerve wrapping with anti-adhesion devices to nerve coverage or wrapping with vascularized tissue.The authors’classification of and therapeutic approach to peripheral nerve scar lesions aims at promoting a logical approach based on the analysis of lesion type(perineural,or endoneural and perineural),pain type(due to traction or external trauma,pain at rest),and number of previous operations.Patients need to be informed that multiple procedures may be required,that outcomes may be partial,and that surgery can potentially worsen preoperative conditions.The review found no evidence for the best therapeutic approach to scar neuropathy,but there is consensus on a multidisciplinary approach. | Pierluigi Tos Alessandro Crosio Pierfrancesco Pugliese Roberto Adani Francesca Toia Stefano Artiaco | 2015 | Plastic and Aesthetic Research2015，2，1： | 1 |
| 19 | Borna disease virus persistentinfection activates mitogen-activated protein kinase and blocks neuronaldifferentiation of PC12 cells显示文摘 | HANS A SYAN S CROSIO C | 2001 | J Biolog Chem2001，276，10： | 1 |
| 20 | Apoptotic mechanisms in mutant LRRK2-mediated cell death显示文摘 | laccarino C Crosio C Vitale C | 2007 | Hum Mol Genet2007，16，11： | 1 |
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